Reduced Quantitative Ultrasound Bone Mineral Density in HIV-Infected Patients on Antiretroviral Therapy in Senegal

Background: Bone status in HIV-infected patients on antiretroviral treatment (ART) is poorly documented in resource-limited settings. We compared bone mineral density between HIV-infected patients and control subjects from Dakar, Senegal. Methods: A total of 207 (134 women and 73 men) HIV-infected patients from an observational cohort in Dakar (ANRS 1215) and 207 age-and sex-matched controls from the general population were enrolled. Bone mineral density was assessed by quantitative ultrasound (QUS) at the calcaneus, an alternative to the reference method (i.e. dual X-absorptiometry), often not available in resource-limited countries. Results: Mean age was 47.0 (+/- 8.5) years. Patients had received ART for a median duration of 8.8 years; 45% received a protease inhibitor and 27% tenofovir; 84% had undetectable viral load. Patients had lower body mass index (BMI) than controls (23 versus 26 kg/m(2), P<0.001). In unadjusted analysis, QUS bone mineral density was lower in HIV-infected patients than in controls (difference: -0.36 standard deviation, 95% confidence interval (CI): -0.59;-0.12, P = 0.003). Adjusting for BMI, physical activity, smoking and calcium intake attenuated the difference (-0.27, CI: -0.53; -0.002, P = 0.05). Differences in BMI between patients and controls explained a third of the difference in QUS bone mineral density. Among patients, BMI was independently associated with QUS bone mineral density (P<0.001). An association between undetectable viral load and QUS bone density was also suggested (beta = 0.48, CI: 0.02; 0.93; P = 0.04). No association between protease inhibitor or tenofovir use and QUS bone mineral density was found. Conclusion: Senegalese HIV-infected patients had reduced QUS bone mineral density in comparison with control subjects, in part related to their lower BMI. Further investigation is needed to clarify the clinical significance of these observations

Post-mortem Changes in Chemical Profile and their Influence on Corpse Removal in Ants

In order to decrease the risk of pathogen transmission, ants remove corpses from the vicinity of nests, but little is known about the underlying mechanisms. In particular, it is unclear how the odor profile of corpses changes with time since death and how any changes might relate to behavior. We have addressed these questions in the red ant Myrmica rubra, where we asked how the time since death determines the ability of workers to discriminate a dead individual from a live one, and whether dead workers are removed in a similar way when they originate from the same or an alien colony. We found that ants could discriminate alien from nestmate corpses up to 2 days after death, since the former continued to elicit aggressive behavior over that period. For dead nestmates, only 15 % of corpses were removed when freshly killed but this rises to 80 % for corpses between 1 to 6 days post mortem. Using gas chromatography, we found that oleic and linoleic acids, which are absent on freshly killed corpses, appeared post mortem and were in higher quantities on those corpses that were ejected from the nest vicinity. When added to fresh corpses, linoleic and oleic acids, alone or blended, enhanced removal to levels observed for corpses of 2-6 days post-mortem. Thus, oleic and linoleic acids appear to be important cues involved in corpse recognition and necrophoresis over a long timeframe, and we advance the hypothesis that these fatty acids in combination with other cues may also trigger other behaviors such as prey retrieval. © 2013 Springer Science+Business Media New York.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Chimie d’un comportement prophylactique: la nécrophorèse chez les fourmis.

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Supply-limited weathering regime in a tropical shields basin (Ogooué River basin, Gabon)

International audienceAt the global scale and on geological time scales, mechanical erosion and chemical weathering budgets are linked. Together, these processes contribute to the formation and the degradation of the Earth's critical zone and to the biogeochemical cycles of elements. While the weathering of hot and humid shields areas exhibit low weathering rates because of the depth of the mature depleted soil mantle there, shields areas dominate the continents areas over intertropical regions and, therefore, represent a significant proportion of the global delivery of dissolved matter to the oceans. In addition, these environments are under supply-limited conditions (the weathering rate is limited by the low rates of the erosion) and thus particularly sensitive to long-term variability erosion rates. Despite this importance, weathering-erosion budgets and rates estimation in these environments is sparse, and generally performed at a local scale (soil profiles) or, when performed at a larger catchment scale, the intra cratonic characteristics variabilities (e. g. the diversity of mechanical erosional regimes) are usually not singled out.In the present study, we explored the variability of the weathering intensity of the Ogooué sub-basins (Western central Africa, Gabon) as a function of their geomorphologic, tectonic and lithological setting variability. We analyzed major and trace elements concentration and the strontium and neodymium isotopes of water, suspended matter sediments and bedload sampled in 24 Ogooué tributaries (September 2017 campaign). Our results show that shield areas exhibit a high variability of chemical weathering intensity, which follows the erosional regime characteristics of the studied sub-basins, likely related to their tectonic activity. Three regions can be distinguished: The Bateke plateau (East sub-basins - PB), is composed of pure sandstones (quartz) and is inert in term of tectonic activity and therefore in term of erosion and weathering budget; the northern sub-basins (NB) are subjected to low tectonic activity and exhibit slightly higher erosion and weathering intensity than PB region and, by comparison, southern sub-basins (SB) exhibits uplift activity which is traduced by more intensive erosion and weathering processes.The annual dissolved solid budget of the Ogooué basin is ~2.52 t.yr-1 for a rate of 11.7 t.km-2.yr-1. According to the source discrimination method performed based on the geochemical analysis, the atmospheric inputs contributes to around 20% to the TDS, the silicate weathering contribution dominates the dissolved exports throughout 70% of its production while the carbonates weathering lowly contributes to the TDS production.By comparison to the other large shields rivers, this basin exhibit a lower range of chemical silicate weathering rate than most of the world's large rivers, with values similar to those of the Congo River. This new dataset provides a key information to complete the World River chemistry database, which is limited for inter-tropical regions, especially in tectonically quiescent environments. Moreover, this study provides new data for tropical shields contexts allowing for the exploration of the interactions between erosion rates and climate in the control of continental weathering rates, and their relationships with long-term carbon cycle and short-term biogeochemical cycles

AP-1 Signaling by Fra-1 Directly Regulates HMGA1 Oncogene Transcription in Triple-Negative Breast Cancers

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Contrasted Chemical Weathering Rates in Cratonic Basins: The Ogooué and Mbei Rivers, Western Central Africa

International audienceDespite the absence of tectonic activity, cratonic environments are characterized by strongly variable, and in places significant, rock weathering rates. This is shown here through an exploration of the weathering rates in two inter-tropical river basins from the Atlantic Central Africa: the Ogooué and Mbei River basins, Gabon. We analyzed the elemental and strontium isotope composition of 24 water samples collected throughout these basins. Based on the determination of the major element sources we estimate that the Ogooué and Mbei rivers total dissolved solids (TDS) mainly derive from silicate chemical weathering. The chemical composition of the dissolved load and the area-normalized solute fluxes at the outlet of the Ogooué are similar to those of other West African rivers (e.g., Niger, Nyong, or Congo). However, chemical weathering rates (TZ+sil rate expressed as the release rate of the sum of cations by silicate chemical weathering) span the entire range of chemical weathering intensities hitherto recorded in worldwide cratonic environments. In the Ogooué-Mbei systems, three regions can be distinguished: (i) the Eastern sub-basins draining the Plateaux Batéké underlain by quartz-rich sandstones exhibit the lowest TZ+sil rates, (ii) the Northern sub-basins and the Mbei sub-basins, which drain the southern edge of the tectonically quiescent South Cameroon Plateau, show intermediate TZ+sil rates and (iii) the Southern sub-basins characterized by steeper slopes record the highest TZ+sil rates. In region (ii), higher DOC concentrations are associated with enrichment of elements expected to form insoluble hydrolysates in natural waters (e.g., Fe, Al, Th, REEs) suggesting enhanced transport of these elements in the colloidal phase. In region (iii), we suggest that a combination of mantle-induced dynamic uplift and lithospheric destabilization affecting the rim of the Congo Cuvette induces slow base level lowering thereby enhancing soil erosion, exhumation of fresh primary minerals, and thus weathering rates. The study points out that erosion of lateritic covers in cratonic areas can significantly enhance chemical weathering rates by bringing fresh minerals in contact with meteoric water. The heterogeneity of weathering rates amongst cratonic regions thus need to be considered for reconstructing the global, long-term carbon cycle and its control on Earth climate

Physical erosion rates in Ogooué and Mbei Rivers (Gabon, Western Central Africa): insights for Cratonic Catchments.

International audienceWe measured the long term physical denudation of the Ogooué River catchment using 10Be. These measurements are averaged over 25-200 ka (average 40 ka), depending on the physical denudation rate. The denudation rate of the Ogooué River catchment is slow (38 t/km2/a, 15 m/Ma), slightly higher than the Equatorial West Africa (from Senegal to Angola, 26 t/km2/a, 10 m/Ma). Physical denudation and chemical weathering fall within the same order of magnitude. Thus, although low, chemical weathering, is substantial compared to physical denudation, its contribution is likely over 30% of the total denudation.Denudation rates are spatially variable (from 10 to 60 t/km2/a) within this large Ogooué River catchment. Over the long term, this variability exhibits a fairly close match of physical denudation/chemical weathering, except in the Batéké Plateaux area, because they are made up of already weathered detrital material and their modern flux of solutes is therefore very low (~9.5 t/km2/a). The spatial distribution is similar to the one described in Moquet et al. (2021)'s work, i.e. the southern part of the catchment is denuding twice as fast as the northern part. We show here that the whole picture did not vary much since 100 ka, as shown by both methods giving consistent results. Faster denudation in the south of the catchment may be related to some more uplift than in the north caused by the south African superswell

Enfances de classe. De l'inégalité parmi les enfants

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Door-to-balloon delays before primary angioplasty in the Regional Acute Myocardial Infarction Registry of Brittany. An analysis of the Observatoire Régional Breton sur l'Infarctus du myocarde (ORBI).

International audienceBACKGROUND: Minimizing delays to coronary reperfusion is critical in the management of acute myocardial infarction (AMI). AIMS: To determine delays in in-hospital management and factors associated with delays of over 45min. METHODS: We analysed data from the Observatoire Régional Breton sur l'Infarctus, a registry of AMI patients admitted within 24h of symptom onset (July 2007 to December 2008) to an interventional cardiology centre in Brittany. Prehospital delay was defined as time between first responder arrival at the patient and patient arrival at an interventional cardiovascular centre. In-hospital delay was defined as time between admission to the interventional cardiovascular centre and first balloon inflation. Patients were grouped according to duration of in-hospital delay (>45 v

QUS bone mineral density and lifestyle factors according to HIV status and clinical characteristics of HIV-infected patients.

<p>Note: Data are no. (%) unless otherwise indicated.</p><p>BUA, bone ultrasound attenuation; SD, standard deviation; BMI, body mass index; HCV Ab, hepatitis C virus serological status; ART, antiretroviral treatment; IQR, interquartile range; PI, protease inhibitor; TDF, tenofovir disoproxyl fumarate.</p