10 research outputs found

    Large n limit of Gaussian random matrices with external source, Part III: Double scaling limit

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    We consider the double scaling limit in the random matrix ensemble with an external source \frac{1}{Z_n} e^{-n \Tr({1/2}M^2 -AM)} dM defined on n×nn\times n Hermitian matrices, where AA is a diagonal matrix with two eigenvalues ±a\pm a of equal multiplicities. The value a=1a=1 is critical since the eigenvalues of MM accumulate as nn \to \infty on two intervals for a>1a > 1 and on one interval for 0<a<10 < a < 1. These two cases were treated in Parts I and II, where we showed that the local eigenvalue correlations have the universal limiting behavior known from unitary random matrix ensembles. For the critical case a=1a=1 new limiting behavior occurs which is described in terms of Pearcey integrals, as shown by Br\'ezin and Hikami, and Tracy and Widom. We establish this result by applying the Deift/Zhou steepest descent method to a 3×33 \times 3-matrix valued Riemann-Hilbert problem which involves the construction of a local parametrix out of Pearcey integrals. We resolve the main technical issue of matching the local Pearcey parametrix with a global outside parametrix by modifying an underlying Riemann surface.Comment: 36 pages, 9 figure

    Influence of dietary methionine on metabolism of DDT in the rat

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    Sizing and Control of a Hybrid Ship Propulsion System Using Multi-Objective Double-Layer Optimization

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    Ship hybridization has received some interests recently in order to achieve the emission target by 2050. However, designing and optimizing a hybrid propulsion system is a complicated problem. Sizing components and optimizing energy management control are coupled with each other. This paper applies a nested double-layer optimization architecture to optimize the sizing and energy management of a hybrid offshore support vessel. Three different power sources, namely diesel engines, batteries and fuel cells, are considered which increases the complexity of the optimization problem. The optimal sizing of the components and their corresponding energy management strategies are illustrated. The effects of the operational profiles and the emission reduction targets on the hybridization design are studied for this particular type of vessel. The results prove that a small emission reduction target of about 10% can be achieved by improving the diesel engine efficiency using the batteries only while the achievement of a larger emission reduction target mainly depends on the amount of the hydrogen and/or on-shore charging electricity consumed. Some design guidelines for hybridization are derived for this particular ship which could be also valid for other vessels with similar operational profiles.</p

    Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: Results from an international snapshot audit

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    Background: A right hemicolectomy is among the most commonly performed operations for colon cancer, but modern high-quality, multination data addressing the morbidity and mortality rates are lacking. Objective: This study reports the morbidity and mortality rates for right-sided colon cancer and identifies predictors for unfavorable short-term outcome after right hemicolectomy. Design: This was a snapshot observational prospective study. Setting: The study was conducted as a multicenter international study. Patients: The 2015 European Society of Coloproctology snapshot study was a prospective multicenter international series that included all patients undergoing elective or emergency right hemicolectomy or ileocecal resection over a 2-month period in early 2015. This is a subanalysis of the colon cancer cohort of patients. Main Outcome Measures: Predictors for anastomotic leak and 30-day postoperative morbidity and mortality were assessed using multivariable mixed-effect logistic regression models after variables selection with the Lasso method. Results: Of the 2515 included patients, an anastomosis was performed in 97.2% (n = 2444), handsewn in 38.5% (n = 940) and stapled in 61.5% (n = 1504) cases. The overall anastomotic leak rate was 7.4% (180/2444), 30-day morbidity was 38.0% (n = 956), and mortality was 2.6% (n = 66). Patients with anastomotic leak had a significantly increased mortality rate (10.6% vs 1.6% no-leak patients; p 65 0.001). At multivariable analysis the following variables were associated with anastomotic leak: longer duration of surgery (OR = 1.007 per min; p = 0.0037), open approach (OR = 1.9; p = 0.0037), and stapled anastomosis (OR = 1.5; p = 0.041). Limitations: This is an observational study, and therefore selection bias could be present. For this reason, a multivariable logistic regression model was performed, trying to correct possible confounding factors. Conclusions: Anastomotic leak after oncologic right hemicolectomy is a frequent complication, and it is associated with increased mortality. The key contributing surgical factors for anastomotic leak were anastomotic technique, surgical approach, and duration of surgery

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