703 research outputs found
Electronic structure near the 1/8-anomaly in La-based cuprates
We report an angle resolved photoemission study of the electronic structure
of the pseudogap state in \NdLSCO ( K). Two opposite dispersing Fermi
arcs are the main result of this study. The several scenarios that can explain
this observation are discussed.Comment: A high-resolution version can be found at
http://lns.web.psi.ch/lns/download/Pockets/arXiv.pd
Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans
Peer reviewedPublisher PD
The coherent {\it d}-wave superconducting gap in underdoped LaSrCuO as studied by angle-resolved photoemission
We present angle-resolved photoemission spectroscopy (ARPES) data on
moderately underdoped LaSrCuO at temperatures below and
above the superconducting transition temperature. Unlike previous studies of
this material, we observe sharp spectral peaks along the entire underlying
Fermi surface in the superconducting state. These peaks trace out an energy gap
that follows a simple {\it d}-wave form, with a maximum superconducting gap of
14 meV. Our results are consistent with a single gap picture for the cuprates.
Furthermore our data on the even more underdoped sample
LaSrCuO also show sharp spectral peaks, even at the
antinode, with a maximum superconducting gap of 26 meV.Comment: Accepted by Phys. Rev. Let
Spectroscopic evidence for preformed Cooper pairs in the pseudogap phase of cuprates
Angle-resolved photoemission on underdoped LaSrCuO
reveals that in the pseudogap phase, the dispersion has two branches located
above and below the Fermi level with a minimum at the Fermi momentum. This is
characteristic of the Bogoliubov dispersion in the superconducting state. We
also observe that the superconducting and pseudogaps have the same d-wave form
with the same amplitude. Our observations provide direct evidence for preformed
Cooper pairs, implying that the pseudogap phase is a precursor to
superconductivity
Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts
peer-reviewedBackground: The genus Lactobacillus is characterized by an extraordinary degree of phenotypic and genotypic diversity, which recent genomic analyses have further highlighted. However, the choice of species for sequencing has been non-random and unequal in distribution, with only a single representative genome from the L. salivarius clade available to date. Furthermore, there is no data to facilitate a functional genomic analysis of motility in the lactobacilli, a trait that is restricted to the L. salivarius clade. Results: The 2.06 Mb genome of the bovine isolate Lactobacillus ruminis ATCC 27782 comprises a single circular chromosome, and has a G+C content of 44.4%. In silico analysis identified 1901 coding sequences, including genes for a pediocin-like bacteriocin, a single large exopolysaccharide-related cluster, two sortase enzymes, two CRISPR loci and numerous IS elements and pseudogenes. A cluster of genes related to a putative pilin was identified, and shown to be transcribed in vitro. A high quality draft assembly of the genome of a second L. ruminis strain, ATCC 25644 isolated from humans, suggested a slightly larger genome of 2.138 Mb, that exhibited a high degree of synteny with the ATCC 27782 genome. In contrast, comparative analysis of L. ruminis and L. salivarius identified a lack of long-range synteny between these closely related species. Comparison of the L. salivarius clade core proteins with those of nine other Lactobacillus species distributed across 4 major phylogenetic groups identified the set of shared proteins, and proteins unique to each group. Conclusions: The genome of L. ruminis provides a comparative tool for directing functional analyses of other members of the L. salivarius clade, and it increases understanding of the divergence of this distinct Lactobacillus lineage from other commensal lactobacilli. The genome sequence provides a definitive resource to facilitate investigation of the genetics, biochemistry and host interactions of these motile intestinal lactobacilli
Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
This article is open access.The objective of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI) task force on fluid and drug therapy in adults with acute respiratory distress syndrome (ARDS) was to provide clinically relevant, evidence-based treatment recommendations according to standards for trustworthy guidelines.The guideline was developed according to standards for trustworthy guidelines, including a systematic review of the literature and use of the GRADE methodology for assessment of the quality of evidence and for moving from evidence to recommendations.A total of seven ARDS interventions were assessed. We suggest fluid restriction in patients with ARDS (weak recommendation, moderate quality evidence). Also, we suggest early use of neuromuscular blocking agents (NMBAs) in patients with severe ARDS (weak recommendation, moderate quality evidence). We recommend against the routine use of other drugs, including corticosteroids, beta2 agonists, statins, and inhaled nitric oxide (iNO) or prostanoids in adults with ARDS (strong recommendations: low- to high-quality evidence). These recommendations do not preclude the use of any drug or combination of drugs targeting underlying or co-existing disorders.This guideline emphasizes the paucity of evidence of benefit - and potential for harm - of common interventions in adults with ARDS and highlights the need for prudence when considering use of non-licensed interventions in this patient population.Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.
- …