Using AUSGeoid2020 and its error grids in surveying computations

We present summarised formulas and worked examples for the propagation of geoid and vertical deflection errors through some common geodetic surveying computations, as well as a demonstration of their effects on least squares adjustments of small simulated geodetic networks. We also present location-specific uncertainties for the vertical deflections derived from the horizontal gradients of the AGQG2017 gravimetric-only quasigeoid model, upon which AUSGeoid2020 is based

Can Europe recover without credit?

Data from 135 countries covering five decades suggests that creditless recoveries, in which the stock of real credit does not return to the pre-crisis level for three years after the GDP trough, are not rare and are characterised by remarkable real GDP growth rates: 4.7 percent per year in middle-income countries and 3.2 percent per year in high-income countries. However, the implications of these historical episodes for the current European situation are limited, for two main reasons. First, creditless recoveries are much less common in highincome countries, than in low-income countries which are financially undeveloped. European economies heavily depend on bank loans and research suggests that loan supply played a major role in the recent weak credit performance of Europe. There are reasons to believe that, despite various efforts, normal lending has not yet been restored. Limited loan supply could be disruptive for the European economic recovery and there has been only a minor substitution of bank loans with debt securities. Second, creditless recoveries were associated with significant real exchange rate depreciation, which has hardly occurred so far in most of Europe. This stylised fact suggests that it might be difficult to re-establish economic growth in the absence of sizeable real exchange rate depreciation, if credit growth does not return

The AUSGeoid09 model of the Australian Height Datum

AUSGeoid09 is the new Australia-wide gravimetric quasigeoid model that has been a posteriori fitted to the Australian Height Datum (AHD) so as to provide a product that is practically useful for the more direct determination of AHD heights from Global Navigation Satellite Systems (GNSS). This approach is necessary because the AHD is predominantly a third-order vertical datum that contains a ~1 m north-south tilt and ~0.5 m regional distortions with respect to the quasigeoid, meaning that GNSS-gravimetric-quasigeoid and AHD heights are inconsistent. Since the AHD remains the official vertical datum in Australia, it is necessary to provide GNSS users with effective means of recovering AHD heights. The gravimetric component of the quasigeoid model was computed using a hybrid of the remove-compute-restore technique with a degree-40 deterministically modified kernel over a one-degree spherical cap, which is superior to the remove-compute-restore technique alone in Australia (with or without a cap). This is because the modified kernel and cap combine to filter long-wavelength errors from the terrestrial gravity anomalies. The zero-tide EGM2008 global gravitational model to degree and order 2190 was used as the reference field.Other input data are: ~1.4 million land gravity anomalies from Geoscience Australia, 1'x1' DNSC2008GRA altimeter-derived gravity anomalies offshore, the 9"x9" GEODATA-DEM9S Australian digital elevation model, and a readjustment of Australian National Levelling Network (ANLN) constrained to the CARS2006 dynamic ocean topography model. In order to determine the numerical integration parameters for the modified kernel, the gravimetric component of AUSGeoid09 was compared with 911 GNSS-observed ellipsoidal heights at benchmarks. The standard deviation of fit to the GNSS-AHD heights is 222 mm, which dropped to 134 mm for the readjusted GNSS-ANLN heights, showing that careful consideration now needs to be given to the quality of the levelling data used to assess gravimetric quasigeoid models. The publicly released version of AUSGeoid09 also includes a geometric component that models the difference between the gravimetric quasigeoid and the zero surface of the AHD at 6,794 benchmarks. This a posteriori fitting used least-squares collocation (LSC) in cross-validation mode to determine a correlation length of 75 km for the analytical covariance function, whereas the noise was taken from the estimated standard deviation of the GNSS ellipsoidal heights. After this LSC surface-fitting, the standard deviation of fit reduced to 30 mm, one third of which is attributable to the uncertainty in the GNSS ellipsoidal heights

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells

The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new markers and targets for prostate cancer treatment. GlycineN-methyltransferase (GNMT) is aS-adenosylmethionine-dependent methyltransferase that has been recently identified as a novel androgen-regulated gene in prostate cancer cells. Although the importance of this protein in prostate cancer progression has been extensively addressed, little is known about the mechanism of its androgen regulation. Here, we show that GNMT expression is stimulated by androgen in androgen receptor (AR) expressing cells and that the stimulation occurs at the mRNA and protein levels. We have identified an androgen response element within the first exon of theGNMTgene and demonstrated that AR binds to this elementin vitroandin vivo. Together, these studies identify GNMT as a direct transcriptional target of the AR. As this is an evolutionarily conserved regulatory element, this highlights androgen regulation as an important feature of GNMT regulation.</jats:p

The Left Hand Second to Fourth Digit Ratio (2D:4D) Does Not Discriminate World-Class Female Gymnasts from Age Matched Sedentary Girls

INTRODUCTION: The second to fourth-digit-ratio (2D:4D), a putative marker of prenatal androgen action and a sexually dimorphic trait, has been suggested to be related with sports performance, although results are not univocal. If this relation exists, it is most likely to be detected by comparing extreme groups on the continuum of sports performance. METHODS: In this study the 2D:4D ratio of world-class elite female artistic gymnasts (n = 129), competing at the 1987 Rotterdam World-Championships was compared to the 2D:4D ratio of sedentary age-matched sedentary girls (n = 129), alongside with other anthropometric characteristics including other sexually dimorphic traits such as an androgyny index (Bayer & Bayley) and Heath-Carter somatotype components (endomorphy, mesomorphy, ectomorphy) using AN(C)OVA. 2D:4D was measured on X-rays of the left hand. RESULTS: Left hand 2D:4D digit ratio in world class elite female gymnasts (0.921±0.020) did not differ significantly from 2D:4D in age-matched sedentary girls (0.924±0.018), either with or without inclusion of potentially confounding covariates such as skeletal age, height, weight, somatotype components or androgyny index. Height (161.9±6.4 cm vs 155.4±6.6 cm p<0.01), weight (53.9±7.6 kg vs 46.2 6.3 kg p<0.01), BMI (20.51±2.41 kg/m(2) vs 19.05±1.56 kg/m(2)), skeletal age (15.2±1.1 y vs 14.5±1.2 y p>0.01), somatotype components (4.0/3.0/2.9 vs 1.7/3.7/3.2 for endomorphy (p<0.01), mesomorphy (p<0.01) and ectomorphy (p<0.05) respectively) all differed significantly between sedentary girls and elite gymnasts. As expressed by the androgyny index, gymnasts have, on average, broader shoulders relative to their hips, compared to the reference sample. Correlations between the 2D:4D ratio and chronological age, skeletal age, and the anthropometric characteristics are low and not significant. CONCLUSION: Although other anthropometric characteristics of sexual dimorphism were significantly different between the two samples, the present study cannot discriminate sedentary girls from world-class female gymnasts by means of the left hand 2D:4D ratio

Respiratory Evolution Facilitated the Origin of Pterosaur Flight and Aerial Gigantism

Pterosaurs, enigmatic extinct Mesozoic reptiles, were the first vertebrates to achieve true flapping flight. Various lines of evidence provide strong support for highly efficient wing design, control, and flight capabilities. However, little is known of the pulmonary system that powered flight in pterosaurs. We investigated the structure and function of the pterosaurian breathing apparatus through a broad scale comparative study of respiratory structure and function in living and extinct archosaurs, using computer-assisted tomographic (CT) scanning of pterosaur and bird skeletal remains, cineradiographic (X-ray film) studies of the skeletal breathing pump in extant birds and alligators, and study of skeletal structure in historic fossil specimens. In this report we present various lines of skeletal evidence that indicate that pterosaurs had a highly effective flow-through respiratory system, capable of sustaining powered flight, predating the appearance of an analogous breathing system in birds by approximately seventy million years. Convergent evolution of gigantism in several Cretaceous pterosaur lineages was made possible through body density reduction by expansion of the pulmonary air sac system throughout the trunk and the distal limb girdle skeleton, highlighting the importance of respiratory adaptations in pterosaur evolution, and the dramatic effect of the release of physical constraints on morphological diversification and evolutionary radiation

Red Clover Improves the Energy to Protein Balance of Lucerne-Grass Herbage

Low ratio of readily fermentable carbohydrate to soluble protein concentrations in lucerne (Medicago sativa L.) leads to inefficient use of herbage N by ruminants. To improve the energy to protein balance in lucerne-grass herbage, four proportions of lucerne:red clover (Trifolium pratense L.) were compared in mixtures with and without grasses: timothy (Phleum pratense L.) and tall fescue (Schedonorus arundinaceus Schreb. Dumort.) in Quebec (QC, Canada). In the first post-seeding year, red clover proportion averaged (across grasses and four harvests) 0, 37, 59, and 74% in herbage mixtures. Increasing the proportion of red clover caused a slight but significant decrease in herbage total nitrogen (TN) concentration (32 to 31 g kg-1 DM) but substantial decreases in non-protein N (PA), rapidly (PB1) and moderately (PB2) degraded protein fractions, and a significant increase in the slowly degraded protein fractions (PB3+PC) (157 to 308 g kg-1 TN). With the inclusion of 74% of red clover, the ratio of soluble sugar to crude protein (CP) in herbage increased from 0.25 to 0.36 because of the increase in the soluble sugar concentration (48 to 66 g kg-1 DM). The inclusion of red clover in mixture with lucerne improved the energy to CP balance compared to lucerne alone, and caused a linear increase in the herbage in vitro neutral detergent fiber digestibility from 568 to 639 g kg-1 aNDF with similar herbage dry matter yield (10.3 Mg ha-1)