9,725 research outputs found
The X-ray and radio emission from SN 2002ap: The importance of Compton scattering
The radio and X-ray observations of the Type Ic supernova SN 2002ap are
modeled. We find that inverse Compton cooling by photospheric photons explains
the observed steep radio spectrum, and also the X-ray flux observed by XMM.
Thermal emission from the shock is insufficient to explain the X-ray flux. The
radio emitting region expands with a velocity of, roughly, 70,000 km/s. From
the ratio of X-ray to radio emission we find that the energy densities of
magnetic fields and relativistic electrons are close to equipartion.Comment: 15 pages, 2 figures, ApJ accepte
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis
Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo. Deletion of the hypoxia response element of the promoter region of the gene encoding VEGF in mice causes a reduction in neural VEGF expression, and results in adult-onset motor neurone degeneration that resembles amyotrophic lateral sclerosis (ALS). Investigating the molecular pathways to neurodegeneration in the VEGF(delta/delta) mouse model of ALS may improve understanding of the mechanisms of motor neurone death in the human disease.
Results: Microarray analysis was used to determine the transcriptional profile of laser captured spinal motor neurones of transgenic and wild-type littermates at 3 time points of disease. 324 genes were significantly differentially expressed in motor neurones of presymptomatic VEGF(delta/delta) mice, 382 at disease onset, and 689 at late stage disease. Massive transcriptional downregulation occurred with disease progression, associated with downregulation of genes involved in RNA processing at late stage disease. VEGF(delta/delta) mice showed reduction in expression, from symptom onset, of the cholesterol synthesis pathway, and genes involved in nervous system development, including axonogenesis, synapse formation, growth factor signalling pathways, cell adhesion and microtubule-based processes. These changes may reflect a reduced capacity of VEGF(delta/delta) mice for maintenance and remodelling of neuronal processes in the face of demands of neural plasticity. The findings are supported by the demonstration that in primary motor neurone cultures from VEGF(delta/delta) mice, axon outgrowth is significantly reduced compared to wild-type littermates.
Conclusions: Downregulation of these genes involved in axon outgrowth and synapse formation in adult mice suggests a hitherto unrecognized role of VEGF in the maintenance of neuronal circuitry. Dysregulation of VEGF may lead to neurodegeneration through synaptic regression and dying-back axonopathy
Spectral/hp element methods: recent developments, applications, and perspectives
The spectral/hp element method combines the geometric flexibility of the
classical h-type finite element technique with the desirable numerical
properties of spectral methods, employing high-degree piecewise polynomial
basis functions on coarse finite element-type meshes. The spatial approximation
is based upon orthogonal polynomials, such as Legendre or Chebychev
polynomials, modified to accommodate C0-continuous expansions. Computationally
and theoretically, by increasing the polynomial order p, high-precision
solutions and fast convergence can be obtained and, in particular, under
certain regularity assumptions an exponential reduction in approximation error
between numerical and exact solutions can be achieved. This method has now been
applied in many simulation studies of both fundamental and practical
engineering flows. This paper briefly describes the formulation of the
spectral/hp element method and provides an overview of its application to
computational fluid dynamics. In particular, it focuses on the use the
spectral/hp element method in transitional flows and ocean engineering.
Finally, some of the major challenges to be overcome in order to use the
spectral/hp element method in more complex science and engineering applications
are discussed
How Advanced Change Patterns Impact the Process of Process Modeling
Process model quality has been an area of considerable research efforts. In
this context, correctness-by-construction as enabled by change patterns
provides promising perspectives. While the process of process modeling (PPM)
based on change primitives has been thoroughly investigated, only little is
known about the PPM based on change patterns. In particular, it is unclear what
set of change patterns should be provided and how the available change pattern
set impacts the PPM. To obtain a better understanding of the latter as well as
the (subjective) perceptions of process modelers, the arising challenges, and
the pros and cons of different change pattern sets we conduct a controlled
experiment. Our results indicate that process modelers face similar challenges
irrespective of the used change pattern set (core pattern set versus extended
pattern set, which adds two advanced change patterns to the core patterns set).
An extended change pattern set, however, is perceived as more difficult to use,
yielding a higher mental effort. Moreover, our results indicate that more
advanced patterns were only used to a limited extent and frequently applied
incorrectly, thus, lowering the potential benefits of an extended pattern set
Radio Emission and Particle Acceleration in SN 1993J
The radio light curves of SN 1993J are found to be well fit by a synchrotron
spectrum, suppressed by external free-free absorption and synchrotron
self-absorption. A standard r^-2 circumstellar medium is assumed, and found to
be adequate. The magnetic field and number density of relativistic electrons
behind the shock are determined. The strength of the magnetic field argues
strongly for turbulent amplification behind the shock. The ratio of the
magnetic and thermal energy density behind the shock is ~0.14. Synchrotron and
Coulomb cooling dominate the losses of the electrons. The injected electron
spectrum has a power law index -2.1, consistent with diffusive shock
acceleration, and the number density scales with the thermal electron energy
density. The total energy density of the relativistic electrons is, if
extrapolated to gamma ~ 1, ~ 5x10^-4 of the thermal energy density. The
free-free absorption required is consistent with previous calculations of the
circumstellar temperature of SN 1993J, T_e ~ (2-10)x10^5 K. The relative
importance of free-free absorption, Razin suppression, and the synchrotron
self-absorption effect for other supernovae are briefly discussed. Guidelines
for the modeling and interpretation of VLBI observations are given.Comment: accepted for Ap.
Detecting a Light Stop from Top Decays at the Tevatron
We study the possibility of discovering or excluding a light top squark
(stop) based on top quark decays in the t-tbar events produced at the Fermilab
Tevatron. In particular, we consider the Minimal Supersymmetric Standard Model
with the sparticle spectrum m_{chi^+_1}+m_b, M_W+m_{chi^0_1}+m_b > m_{stop} >
m_{chi^0_1}+m_c, where chi^0_1 is the lightest neutralino and chi^+_1 is the
lightest chargino, so that t -> stop chi^0_1 and stop -> c chi^0_1. All other
sparticle masses are assumed to be heavier than m_t. Such a spectrum seeks to
explain the experimental values of alpha_s(M_Z^2), R_b and A_{LR} obtained from
LEP/SLC data. We find that the prospect to observe a light stop via this
channel at the Tevatron is very promising.Comment: 12 pages with 1 Postscript figure using psfig.sty. Postscript file
available at http://sgi2.hep.anl.gov:8001/index.htm
Low-loss singlemode PECVD silicon nitride photonic wire waveguides for 532-900 nm wavelength window fabricated within a CMOS pilot line
PECVD silicon nitride photonic wire waveguides have been fabricated in a CMOS pilot line. Both clad and unclad single mode wire waveguides were measured at lambda = 532, 780, and 900 nm, respectively. The dependence of loss on wire width, wavelength, and cladding is discussed in detail. Cladded multimode and singlemode waveguides show a loss well below 1 dB/cm in the 532-900 nm wavelength range. For singlemode unclad waveguides, losses < 1 dB/cm were achieved at lambda = 900 nm, whereas losses were measured in the range of 1-3 dB/cm for lambda = 780 and 532 nm, respectively
Twenty years of BRCA1 and BRCA2 molecular analysis at MMCI : current developments for the classification of variants
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