Perceived Cognitive Impairment in Breast Cancer Survivors and Its Relationships with Psychological Factors

Cognitive complaints are common adverse effects for breast cancer survivors, with potential negative impacts on quality of life or return to work. Identifying subjects at risk could allow to reduce cognitive disorders or to set up appropriate care. In this study we explored current cognitive complaints reported by breast cancer survivors, using the Functional Assessment of Cancer Therapy-Cognition (FACT-Cog) questionnaire and examined the relationships between current cognitive complaints and current psychological symptoms (especially post-traumatic stress symptoms). This large survey showed that about half of breast cancer survivors reported cognitive complaints after cancer treatments. These complaints were mainly associated with chemotherapy, age, self-reported sleep difficulties, the frequency of psychotropic treatments and psychological factors including post-traumatic stress symptoms or. Some modifiable risk factors should be detected early to reduce persistent cognitive complaints after cancer, including sleep difficulties and post-traumatic stress symptoms

Plainte cognitive et facteurs psychologiques associés chez les patientes après un cancer du sein

Cognitive complaints are common adverse effects in cancer patients. Identifying subjects at risk could make it possible to limit their impact. We aimed to explore the relationship between current cognitive complaints and demographic and psychological factors in a group of breast cancer survivors. Through an online survey, cancer survivors reported current cognitive complaints using the FACT-Cog questionnaire (Perceived Cognitive Impairment) and answered questions about their demographic, lifestyle and cancerrelated characteristics. Anxiety, depression, fatigue and post-traumatic stress symptoms were also assessed. We used multivariable logistic regression models to explore the relationships between current cognitive complaints and social and psychological factors. Among the 1393 breast cancer survivors, 47.2% (n=657) had current cognitive complaints. Chemotherapy (OR=2.26, 95%CI=1.67-3.05), age (OR21-44 vs. >65 =0.14, 95%CI=0.07-0.27), sleep difficulties (ORnever vs. often=2.41, 95%CI=1.47-3.95), frequency of psychotropic treatments (ORnever vs. >1/week=1.70,95%CI=1.23-2.36), post-traumatic stress symptoms (OR=2.05, 95%CI=1.57-2.69) and employment status (ORfull-time or part-time vs. sick leave=1.64, 95%CI=1.08-2.49) were strongly associated with current cognitive complaints. In this large study, about half of breast cancer survivors reported cognitive complaints, particularly after chemotherapy. Some risk factors should be detected early to prevent persistent cognitive complaints after cancer: mainly sleep difficulties or post-traumatic stress symptoms.Les troubles cognitifs sont des effets indésirables courants chez les patients atteints de cancer. Identifier des sujets à risque permettrait de limiter leur impact. Nous avons voulu explorer la relation entre la plainte cognitive et les facteurs démographiques et psychologiques chez des patientes après traitement pour un cancer du sein. Grâce à une enquête en ligne, les participantes ont fait part de leurs troubles cognitifs actuels via le questionnaire FACT-Cog (Perceived Cognitive Impairment) et ont répondu à des questions sur leurs caractéristiques démographiques, leur mode de vie et les caractéristiques de leur cancer. L'anxiété, la dépression, la fatigue et le stress post-traumatique ont également été évalués. Nous avons utilisé des modèles de régression logistique multivariable pour explorer les relations entre la plainte cognitive et les facteurs socio-psychologiques. Parmi les 1393 participantes, 47,2% (n=657) présentaient une plainte cognitive. La chimiothérapie (OR=2,26, 95% IC=1,67-3,05), l’âge (OR21-44 vs, >65=0,14,95% IC=0,07-0,27), les troubles du sommeil (ORjamais vs, souvent=2,41,95% IC=1,47- 3,95), les traitements psychotropes (ORjamais vs, >1/semaine=1,70, 95%IC=1,23-2,36), le stress post-traumatique (OR=2,05, 95% IC=1,57-2,69) et le statut professionnel (ORtemps plein ou temps partiel vs, congé maladie=1,64, 95%IC=1,08-2,49) y étaient fortement associés. Dans cette vaste étude, environ la moitié des participantes rapportaient des troubles cognitifs, notamment après une chimiothérapie. Certains facteurs de risque doivent être détectés précocement pour prévenir les plaintes cognitives persistantes après le cancer : les troubles du sommeil ou le stress post-traumatique

Perceived Cognitive Impairment in Breast Cancer Survivors and Its Relationships with Psychological Factors

Cognitive complaints are common adverse effects in cancer patients. Identifying subjects at risk could make it possible to limit their impact. We aimed to explore the relationship between current cognitive complaints and demographic and psychological factors in a group of breast cancer survivors. Through an online survey, cancer survivors reported current cognitive complaints using the FACT-Cog questionnaire (Perceived Cognitive Impairment) and answered questions about their demographics, lifestyle and cancer-related characteristics. Anxiety, depression, fatigue and post-traumatic stress symptoms were also assessed. We used multivariable logistic regression models to explore the relationships between current cognitive complaints and social and psychological factors. Among the 1393 breast cancer survivors, 47.2% (n = 657) reported current cognitive complaints. Chemotherapy (OR = 2.26, 95%CI = 1.67–3.05), age (OR21-44 vs. >65 = 0.14, 95%CI = 0.07–0.27), sleep difficulties (ORnever vs. often = 2.41, 95%CI = 1.47–3.95), frequency of psychotropic treatments (ORnever vs. >1/week = 1.70, 95%CI = 1.23–2.36), post-traumatic stress symptoms (OR = 2.05, 95%CI = 1.57–2.69) and employment status (ORfull-time or part-time vs. sick leave = 1.64, 95%CI = 1.08–2.49) were strongly associated with current cognitive complaints. In this large study, about half of breast cancer survivors reported cognitive complaints, particularly after chemotherapy. Some risk factors should be detected early to reduce persistent cognitive complaints after cancer: mainly sleep difficulties, post-traumatic stress symptoms and psychotropic medications