Estudo da freqüência de ovos de helmintos intestinais em sanitários de uso público de Sorocaba, SP

Foram pesquisados 405 sanitários sendo 11 de praças, 2 da estação ferroviária, 4 da estação rodoviária, 55 de bares e restaurantes, 146 de escolas estaduais, 116 de escolas municipais, 8 de escolas particulares, 36 de postos de saúde, 16 de centros esportivos, 8 de orfanatos e 3 de shopping. Foram usadas lâminasde microscopia comfita adesiva. O material foi coletado pela colagem da fita nos seguintes elementos: 4 campos do assento, maçanetas interna e externa, trinco, registro de torneira e descarga (botão epuxador). Dos 405 sanitários pesquisados, 22 (5,43%) estavam contaminados. Foram encontrados ovos de: Ascaris lumbricoides, ancilostomídeos, Enterobius vermicularis, Taenia sp e Hymenolepis nana, sendo que em 2 sanitários foram encontrados, concomitantemente, ovos de 2 parasitas

Alterations in evoked otoacoustic emissions by the use of meglumine antimoniate in American tegumentary leishmaniasis patients

Submitted by Janaína Nascimento ([email protected]) on 2019-07-19T13:50:23Z No. of bitstreams: 1 ve_Bezerra_Débora_etal_INI_2017.pdf: 1274540 bytes, checksum: ea37b81d1d5c8c29cc86661f270e23ef (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-07-19T14:16:29Z (GMT) No. of bitstreams: 1 ve_Bezerra_Débora_etal_INI_2017.pdf: 1274540 bytes, checksum: ea37b81d1d5c8c29cc86661f270e23ef (MD5)Made available in DSpace on 2019-07-19T14:16:29Z (GMT). No. of bitstreams: 1 ve_Bezerra_Débora_etal_INI_2017.pdf: 1274540 bytes, checksum: ea37b81d1d5c8c29cc86661f270e23ef (MD5) Previous issue date: 2017Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil.Federal University of the State of the Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Brazilian National Council for Scientific and Technological Development. Brasilia, DF, Brazil / Carlos Chagas Filho Foundation for Research Support of the state of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil / Carlos Chagas Filho Foundation for Research Support of the state of Rio de Janeiro. Rio de Janeiro, RJ, Brazil / New University of Lisbon. Hygiene and Tropical Medicine Institute. Lisbon, Portugal.Tegumentary Leishmaniasis (TL) is a neglected, non-contagious, infectious disease, caused by different protozoa species of the Leishmania genus that affects skin and mucous membranes. Meglumine Antimoniate (MA), the first drug of choice for TL treatment in Brazil, has already been associated with cochlear toxicity, which is defined as damages of the cochlea caused by exposure to chemical substances, resulting in reversible or irreversible hearing loss. Auditory monitoring for cochlear toxicity aims at the early detection of auditory disorders, enabling, when possible, hearing to be preserved or an early auditory rehabilitation. Although otoacoustic emissions (OAEs) are used in this monitoring, there is no consensus on the criteria that define cochlear toxicity by this examination. The objective of this study was to describe the characteristics of the OAEs in cochlear toxicity monitoring in TL patients using MA

Auditory monitoring with transient evoked otoacoustic emissions before treatment, at the end of treatment and 1 and 2 months after the end of treatment of meglumine antimoniate in american tegumentary leishmaniasis patients.

<p>Auditory monitoring with transient evoked otoacoustic emissions before treatment, at the end of treatment and 1 and 2 months after the end of treatment of meglumine antimoniate in american tegumentary leishmaniasis patients.</p

Auditory monitoring with distortion product evoked otoacoustic emissions before treatment, at the end of treatment and 1 and 2 months after the end of treatment of meglumine antimoniate in american tegumentary leishmaniasis patients.

<p>* Higher number of alterations in distortion product evoked otoacoustic emissions at the end of treatment than before treatment (p = 0.039).</p

Comparison between presence and absence of alterations in distortion product evoked otoacoustic emissions (DPEOAE) before beginning treatment with Meglumine Antimoniate (MA) of 64 ears of 32 patients with tegumentary leishmaniasis.

<p>Evandro Chagas National Institute of Infectious Diseases–Oswaldo Cruz Foundation, 2016.</p

Comparison of the medians of the signal/noise ratio in distortion product evoked otoacoustic emissions before treatment and at the end of treatment, in patients with tegumentary leishmaniasis treated with meglumine antimoniate, Rio de Janeiro, 2016.

<p>* signal/noise ratio significantly smaller at the end of treatment than before treatment at the frequencies of 2 kHz (difference of 1.7dB; p = 0.016) and 4 kHz (difference of 2.45dB; p = 0.016)</p

3 Sensitivity, specificity, predictive values, false positives and false negatives in the diagnosis of cochlear toxicity from self-reported hearing loss and tinnitus in relation to the ototoxicity alteration at three different frequencies ranges of tone threshold audiometry in 102 patients with American Tegumentary Leishmaniasis treated with meglumine antimoniate.

Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.</p

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IntroductionAmerican Tegumentary Leishmaniasis (ATL) treatment is based on pentavalent antimonials (Sb5+), but these drugs have been associated to several adverse effects. Hearing loss and tinnitus during treatment with meglumine antimoniate (MA) have already been reported. This study aimed to describe the usefulness of self-reporting of hearing loss and tinnitus in diagnosing MA-induced ototoxicity.MethodsA prospective longitudinal study was conducted with 102 patients with parasitological diagnosis of ATL, treated with different MA schemes. The presence of clinical auditory toxicity was defined as the emergence or worsening of self-reporting hearing loss and/or tinnitus during monitoring. Measures of sensitivity, specificity, and the positive and negative predictive value of the patient’s self-reporting of hearing loss and tinnitus in relation to the result of the audiometric test (considered the gold standard) were calculated.ResultsThe age of the evaluated patients ranged from 15 to 81 years, with a median of 41 years, and most were male (73.5%). Seventy-five patients (73.5%) had cutaneous leishmaniasis and 27 (26.5%) mucosal leishmaniasis. Eighty-six patients (84.3%) received intramuscular (IM) treatment and 16 (15.7%) were treated with intralesional MA. During treatment, 18 (17,6%) had tinnitus and 7 (6,9%) had complaint of hearing loss. 53 (52%) patients had cochlear toxicity confirmed by tone threshold audiometry and high frequency audiometry, from which 60% received a dose of 20 mg Sb5+/kg/day (p = 0.015) and 96.2% were treated with IM MA (p = 0.001). Tinnitus has greater specificity and positive predictive value than hearing loss, with a low number of false positives, but with a high false negative value.ConclusionAlthough the large number of false negatives suggests that self-report of hearing loss or tinnitus cannot be considered a good screening test for referring the patient to an audiometry, the low number of false positives suggests the need to value the patient’s complaint for referral. Otherwise, this study reinforces the importance of audiological monitoring during treatment with MA, especially in those patients with self-reporting of hearing loss or tinnitus when treated with 20 mg Sb5+/kg/day via IM.</div