The antenna DSA 3 and its potential use for Radio Astronomy

The European Space Agency (ESA) will inaugurate its third Deep Space Antenna (DSA 3) by the end of 2012. DSA 3 will be located in Argentina near the city of Malarg"ue in the Mendoza province. While the instrument will be primarily dedicated to communications with interplanetary missions, the characteristics of its antenna and receivers will also enable standalone leading scientific contributions, with a high scientific-technological return. We outline here scientific proposals for a radio astronomical use of DSA 3.Comment: 4 pages, submitted as Proceedings for the BAA

Adaptation of the Penetration-Aspiration Scale to Open Partial Horizontal Laryngectomy: reliability analysis

The study aimed at adapting the Penetration-Aspiration scale to OPHL and analysing its reliability

The Penetration–Aspiration Scale: Adaptation to Open Partial Laryngectomy and Reliability Analysis

A standard for assessing swallowing function after open partial horizontal laryngectomy (OPHL) is still not established. The variability in the measures used to investigate swallowing functional outcomes after OPHL limits the communication among clinicians and the possibility to compare and combine results from different studies. The study aims to adapt the PAS to the altered anatomy after OPHLs using fiberoptic endoscopic evaluation of swallowing (FEES) and to test its reliability. To adapt the PAS, two landmarks were identified: the entry of the laryngeal vestibule and the neoglottis. Ninety patients who underwent an OPHL were recruited (27 type I, 31 type II and 32 type III). FEES was performed and video-recorded. Two speech and language therapists (SLTs) independently rated each FEES using the PAS adapted for OPHL (OPHL-PAS). FEES recordings were rated for a second time by both SLTs at least 15 days from the first video analysis. Inter- and intra-rater agreement was assessed using unweighted Cohen's kappa. Overall, inter-rater agreement of the OPHL-PAS was k\u2009=\u20090.863, while intra-rater agreement was k\u2009=\u20090.854. Concerning different OPHL types, inter- and intra-rater agreement were k\u2009=\u20090.924 and k\u2009=\u20090.914 for type I, k\u2009=\u20090.865 and k\u2009=\u20090.790 for type II, and k\u2009=\u20090.808 and k\u2009=\u20090.858 for type III, respectively. The OPHL-PAS is a reliable scale to assess the invasion of lower airway during swallowing in patients with OPHL using FEES. The study represents the first attempt to define standard tools to assess swallowing functional outcome in this population

Influence of the LPM effect and dielectric suppression on particle air showers

An analysis of the influence of the Landau-Migdal-Pomeranchuk (LPM) effect on the development of air showers initiated by astroparticles is presented. The theory of Migdal is studied and compared with other theoretical methods, particularly the Blankenbecler and Drell approach. By means of realistic computer simulations and using algorithms that emulate Migdal's theory, including also the so-called dielectric suppression, we study the behavior of the relevant observables in the case of ultra-high energy primaries. We find that the LPM effect can significantly modify the development of high energy electromagnetic showers in certain cases.Comment: 18 pages, 13 figures, 1 table. To appear in Phys. Rev.

Plasmon-graviton conversion in a magnetic field in TeV-scale gravity

Kaluza-Klein (KK) gravitons emission rates due to plasmon-graviton conversion in magnetic field are computed within the ADD model of TeV-scale gravity. Plasma is described in the kinetic approach as the system of charged particles and Maxwell field both confined on the brane. Interaction with multidimensional gravity living in the bulk with $n$ compact extra dimensions is introduced within the linearized theory. Plasma collective effects enter through the two-point correlation function of the fluctuations of the energy-momentum tensor. The estimate for magnetic stars is presented leading to the lower limit of the D-dimensional Plank mass.Comment: Submitted to Proceedings of "RusGrav-14" International Conference, 27.06-02.07 2011, Ulyanovks, Russi

Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer

Prostate cancer (PCa) is a leading cause of death in the male population commonly treated with androgen deprivation therapy that often relapses as androgen-independent and aggressive castration-resistant prostate cancer (CRPC). Ferroptosis is a recently described form of cell death that requires abundant cytosolic labile iron to promote membrane lipid peroxidation and which can be induced by agents that inhibit the glutathione peroxidase-4 activity such as RSL3. Exploiting in vitro and in vivo human and murine PCa models and the multistage transgenic TRAMP model of PCa we show that RSL3 induces ferroptosis in PCa cells and demonstrate for the first time that iron supplementation significantly increases the effect of RSL3 triggering lipid peroxidation, enhanced intracellular stress and leading to cancer cell death. Moreover, the combination with the second generation anti-androgen drug enzalutamide potentiates the effect of the RSL3 + iron combination leading to superior inhibition of PCa and preventing the onset of CRPC in the TRAMP mouse model. These data open new perspectives in the use of pro-ferroptotic approaches alone or in combination with enzalutamide for the treatment of PCa

Constraints on the Ultra High Energy Photon flux using inclined showers from the Haverah Park array

We describe a method to analyse inclined air showers produced by ultra high energy cosmic rays using an analytical description of the muon densities. We report the results obtained using data from inclined events (60^{\circ}<\theta<80^{\circ}) recorded by the Haverah Park shower detector for energies above 10^19 eV. Using mass independent knowledge of the UHECR spectrum obtained from vertical air shower measurements and comparing the expected horizontal shower rate to the reported measurements we show that above 10^19 eV less than 48 % of the primary cosmic rays can be photons at the 95 % confidence level and above 4 X 10^19 eV less than 50 % of the cosmic rays can be photonic at the same confidence level. These limits place important constraints on some models of the origin of ultra high-energy cosmic rays.Comment: 45 pages, 25 figure