Best practice in license allocation in the oil and gas industry: a review of five countries

The implementation of good practice in the natural resource management processes is crucial to the economic development of many countries. Well managed resources can bring high financial rewards and benefit the entire country, while poor resource management can lead to severe social and economic consequences. The allocation of licenses for the exploration and development of the natural resources is of particular importance in establishing good management and ensuring the accrual of benefits to the country. In this paper we identify an analytic framework for establishing the most suitable license allocation approach in any context, and apply this to five case studies. From this application we draw conclusions regarding best practice and identify the policy implications of this discussion

Energy sustainability of food stores and supermarkets through the installation of pv integrated plants

Food stores and supermarkets are buildings, often with rather similar structures charac-terized by large surfaces and a single floor, that are particularly energy intensive. The energy uses associated with them are mainly electrical, in connection with air conditioning and food refrigeration. These buildings are particularly interesting for a systematic application of photovoltaic (PV) generation technology. After an analysis of the main energy consumption parameters and of the most common benchmarking approaches, standard solutions for the sizing of photovoltaic systems are proposed based on different design objectives, highlighting the potential of each solution proposed. Two specific indicators are defined for the sizing processes. The methodology is tested with reference to two different stores under the zero grid-injection restriction. The results showed how the degree of self-sufficiency for a supermarket obtained with a PV plant can be of the order of 20% in cases without storage system and can be increased over 50% and up to 70–75% but only using relevant battery storage dimensions

Passive solar systems for buildings: Performance indicators analysis and guidelines for the design

Data from the International Energy Agency confirm that in a zero-energy perspective the integration of solar systems in buildings is essential. The development of passive solar strategies has suffered the lack of standard performance indicators and design guidelines. The aim of this paper is to provide a critical analysis of the main passive solar design strategies based on their classification, performance evaluation and selection methods, with a focus on integrability. Climate and latitude affect the amount of incident solar radiation and the heat losses, while integrability mainly depends on the building structure. For existing buildings, shading and direct systems represent the easiest and most effective passive strategies, while building orientation and shape are limited to new constructions: proper design can reduce building energy demand around 40%. Commercial buildings prefer direct use systems while massive ones with integrated heat storage are more suitable for family houses. A proper selection must consider the energy and economic balance of different building services involved: a multi-objective evaluation method represents the most valid tool to determine the overall performance of passive solar strategies

Passive solar solutions for buildings: Criteria and guidelines for a synergistic design

Passive solar system design is an essential asset in a zero-energy building perspective to reduce heating, cooling, lighting, and ventilation loads. The integration of passive systems in building leads to a reduction of plant operation with considerable environmental benefits. The design can be related to intrinsic and extrinsic factors that influence the final performance in a synergistic way. The aim of this paper is to provide a comprehensive view of the elements that influence passive solar systems by means of an analysis of the theoretical background and the synergistic design of various solutions available. The paper quantifies the potential impact of influencing factors on the final performance and then investigates a case study of an existing public building, analyzing the effects of the integration of different passive systems through energy simulations. General investigation has highlighted that latitude and orientation impact energy saving on average by 3–13 and 6–11 percentage points, respectively. The case study showed that almost 20% of the building energy demand can be saved by means of passive solar systems. A higher contribution is given by mixing direct and indirect solutions, as half of the heating and around 25% of the cooling energy demand can be cut off

Passive Solar Solutions for Buildings: Criteria and Guidelines for a Synergistic Design

Passive solar system design is an essential asset in a zero-energy building perspective to reduce heating, cooling, lighting, and ventilation loads. The integration of passive systems in building leads to a reduction of plant operation with considerable environmental benefits. The design can be related to intrinsic and extrinsic factors that influence the final performance in a synergistic way. The aim of this paper is to provide a comprehensive view of the elements that influence passive solar systems by means of an analysis of the theoretical background and the synergistic design of various solutions available. The paper quantifies the potential impact of influencing factors on the final performance and then investigates a case study of an existing public building, analyzing the effects of the integration of different passive systems through energy simulations. General investigation has highlighted that latitude and orientation impact energy saving on average by 3–13 and 6–11 percentage points, respectively. The case study showed that almost 20% of the building energy demand can be saved by means of passive solar systems. A higher contribution is given by mixing direct and indirect solutions, as half of the heating and around 25% of the cooling energy demand can be cut off

Ultrasmall Glucose-Functionalized Au-Carbon Nanohybrids: Exploiting the Warburg Effect to Image Tumors by Multimodal CT/Fluorescence Imaging

Utilizing glucose as a targeting agent represents a pioneering approach in selectively directing nanoparticles towards cancer cells, capitalizing on the pronounced glucose uptake observed in tumors attributable to the Warburg effect. In this study, we have successfully adopted this targeting strategy to facilitate the specific uptake of advanced nanotools, comprising carbon nanocrystals incorporating gold seeds (AuCDs). Leveraging the advantageous optical and size-related properties of carbon nanodots in conjunction with gold-mediated X-ray attenuation capabilities, these hybrid nanomaterials have been engineered as contrast agents for a bi-modal imaging modality, exploiting the synergistic benefits of fluorescence imaging and X-ray computed tomography. Notably, for the synthesis of AuCDs, we present, for the first time, the incorporation of gold seeds within the molecular precursors of carbon nanodots during their solvothermal synthesis process, showcasing the efficacy of this synthetic pathway in yielding nanoscale carbon structures incorporating bioeliminable gold ultrasmall nanoparticles (d < 5 nm). Subsequently, we employed an azido-alkyne click chemistry reaction to functionalize the nanoparticle surface with 2-deoxy-D-glucose as a targeting moiety. The demonstrated cancer-targeting proficiency, as assessed via fluorescence imaging, renders the proposed nanosystem highly promising for a spectrum of applications in precision anticancer theranostics, encompassing both diagnostic and therapeutic endeavors

Immunopathology of Leishmaniasis: an update.

Leishmaniasis represents a severe, increasing, public health problem. The perspective of its control is highly dependent on research progress, on therapeutic manipulations of the immune system, and on vaccine development. There is a correlation between the clinical outcome of Leishmania infection and the cytokine response profile. While a protective immune response against Leishmania has been clearly identified to be related to the influence of a type-1 response and IFN-gamma production, the precise role of T helper (TH) 2 cytokines in non-healing infections requires further exploration. IL-4 and IL-13 (TH2 cytokines) can promote disease progression in cutaneous leishmaniasis, whereas IL-4 would appear to enhance protective type-1 responses in visceral leishmaniasis. Thus, the TH1/TH2 paradigm of resistance/susceptibility to intracellular parasites is probably an oversimplification of a more complicated network of regulatory/counter regulatory interactions. Moreover, the presence of antigen specific regulatory T cell subsets may provide an environment that contributes to the balance between TH1 and TH2 cells. Finally, the involvement of CD8 positive T cells has been described, but the modality of their function in this kind of infection has not been so far elucidated

Immunology of human rickettsial diseases.

Among human rickettsial diseases caused by micro-organisms of the genus Rickettsia (Order Rickettsiales; Family Rickettsiaceae), transmitted to human hosts through arthropod vectors, Mediterranean Spotted Fever, or Boutonneuse Fever, and Rocky Mountain Spotted Fever are considered to be important infectious diseases due to continued prevalence in the developed world, and potentially fatal outcome in severe cases. Proliferation of rickettsiae, at the site of the tick bite, results in focal epidermal and dermal necrosis (tache noire). Rickettsiae then spread via lymphatic vessels to the regional lymph nodes, and, via the bloodstream, to skin, brain, lungs, heart, liver, spleen and kidneys. The pathogen invades and proliferates in the endothelial cells of small vessels, target cells of rickettsial infection, destroying them, and spreading the infection to the endothelia of the vascular tree. The damage of the endothelium, and the subsequent endothelia dysfunction, is followed by the activation of acute phase responses, with alteration in the coagulation and in the cytokine network, together with a transient immune dysregulation, characterized by the reduction in peripheral CD4+ T lymphocytes

An Innovative Enhanced Wall to Reduce the Energy Demand in Buildings

Energy saving in buildings is one of most important issues for European countries. Although in the last years many studies have been carried out in order to reach the zero-consumption house the energy rate due to passive solar heating could be further enhanced. This paper proposes a method for increasing the energy rate absorbed by opaque walls by using a two phase loop thermosyphon connecting the internal and the external façade of a prefabricated house wall. The evaporator zone is embedded into the outside facade and the condenser is indoor placed to heat the domestic environment. The thermosyphon has been preliminary designed and implanted into a wall for a prefabricated house in Italy. An original dynamic thermal model of the building equipped with the thermosyphon wall allowed the evolution of the indoor temperature over time and the energy saving rates. The transient behaviour of the building has been simulated during the winter period by using the EnergyPlusTM software. The annual saving on the heating energy is higher than 50% in the case of a low consumption building

An Innovative Enhanced Wall to Reduce the Energy Demand in Buildings

Energy saving in buildings is one of most important issues for European countries. The 40% of the total European energy consumption is due to building Heating and conditioning. Although in the last years many studies have been carried out in order to reach the zero-consumption house by means of passive solar heating, ventilation or thermal insulation, the energy rate due to passive solar heating could be further enhanced. This paper proposes a method for increasing the energy rate absorbed by opaque walls by using a two phase loop thermosyphon connecting the internal and the external façade of a prefabricated house wall. The evaporator zone is located on the outside face and it is irradiated by the sunlight while the condenser zone is placed on the internal face and releases heat to the domestic environment. The temperature differences between the internal and external wall facades are lower than 30 K and the heat fluxes at the evaporator change during the day from 2 up to 7 x 104 W/m2 K. The thermosyphon has been preliminary designed and implanted into a wall for a prefabricated house in Italy. A thermal model of building equipped with the thermosiphon wall has been used in order to evaluate the impact in terms of energy saving and thermal comfort in a real prefabricated low consumption house. The transient behaviour of the building has been simulated day by day during the winter period by using the EnergyPlusTM software. This solution enhances the thermal comfort of the building by keeping the indoor temperature close to the thermal comfort standard for most of the day. The annual saving on the heating energy is higher than 50% in the case of a low consumption buildin