The Making of a Museum: A Master's Project with the Saxapahaw History Museum

Museums are proven to significantly impact the economic well-being of their local communities. The return on investment of museums in small communities includes increased direct and indirect spending, increased tourism and exposure for local businesses, and an increase in prestige of the town. The purpose of this master's project is to analyze the practices and standards employed for the creation of the Saxapahaw History Museum and archive, and how the Saxapahaw History Museum will positively impact the local society both economically and culturally. After discussing the current operating processes and goals of the museum, I attempt to determine the most applicable and cost-effective methods for the Museum to best preserve its collections and offer suggestions for modifying the current system into one which upholds the standards set forth by the American Museum Association

Optomechanical Design and Analysis for Nanosatellite Laser Communications

The CubeSat Laser Infrared CrosslinK (CLICK) mission is a technology demonstration of a 1.5U laser communications terminal for an intersatellite link. The terminal is deployed on a pair of 3U CubeSats in Low Earth Orbit (LEO). The pointing, acquisition, and tracking (PAT) approach includes both coarse and fine systems. The coarse tracking system uses a beacon laser transmitter and receiver camera. The fine tracking system uses a fast steering mirror and quadrant photodiode. The communications transmit and receive paths include a refractive telescope, transmit laser collimator, and avalanche photodetector (APD) receiver. The communications laser full-width, half maximum (FWHM) beam divergence angle is 14.6 arcseconds, and the beacon laser FWHM divergence is 0:75° (2700 arcseconds). The opto-mechanical design process includes prediction & verification of assembly alignment & calibration, thermoelastic effects, structural modes & static loading, and fastener analysis. The opto-mechanical assembly has the sensors and laser transmitters kinematically mounted to enable on-ground calibration to less than 25.4 mm decenter, or 0.1° tip/tilt. The thermoelastic alignment error between the payload and bus star tracker is estimated via finite element analysis to be less than 9 arcseconds. The payload optical bench is designed with custom thermal isolation and control to maintain 20 ± 10 ° C. The thermal modeling of the payload is described in detail. Structural static loading and fastener analyses of the CLICK payload under launch loads of 30 G verify margins of safety are greater than 10 and above the recommended values. Modal analyses predict the first resonant frequency to be 888 Hz, above typical vehicle structural vibration ranges with a factor of safety greater than 3.5

Bone and joint infections in adults: a comprehensive classification proposal

Ten currently available classifications were tested for their ability to describe a continuous cohort of 300 adult patients affected by bone and joint infections. Each classification only focused, on the average, on 1.3\u2009\ub1\u20090.4 features of a single clinical condition (osteomyelitis, implant-related infections, or septic arthritis), being able to classify 34.8\u2009\ub1\u200924.7% of the patients, while a comprehensive classification system could describe all the patients considered in the study. RESULT AND CONCLUSION: A comprehensive classification system permits more accurate classification of bone and joint infections in adults than any single classification available and may serve for didactic, scientific, and clinical purposes

Design and Prototyping of a Nanosatellite Laser Communications Terminal for the Cubesat Laser Infrared CrosslinK (CLICK) B/C Mission

The CubeSat Laser Infrared CrossLink (CLICK) mission goal is to demonstrate a low cost, high data rate optical transceiver terminal with fine pointing and precision time transfer in aleq1.5U form factor. There are two phases to the technology demonstration for the CLICK mission: CLICK-A downlink, and then CLICK-B/C crosslink and downlink. The topic of this paper is the design and prototyping of the laser communications (lasercom) terminal for the CLICK-B/C phase. CLICK B/C consists of two identical 3U CubeSats from Blue Canyon Technologies that will be launched together in Low Earth Orbit to demonstrate crosslinks at ranges between 25 km and 580 km with a data rate of ≥20 Mbps and a ranging capability better than 0.5 m. Downlinks with data rates of ≥10 Mbps will also be demonstrated to the Portable Telescope for Lasercom (PorTeL) ground station. Link analysis using current parameters & experimental results predicts successful crosslink & downlink communications and ranging. Moreover, closed-loop 3σ fine pointing error is predicted to be less than 39.66 μrad of the 121.0 μrad 1/e² transmit laser divergence. The status of the payload EDU and recent developments of the optomechanical and thermal designs are discussed

Testing of the CubeSat Laser Infrared CrosslinK (CLICK-A) Payload

The CubeSat Laser Infrared CrosslinK (CLICK-A) is a risk-reduction mission that will demonstrate a miniaturized optical transmitter capable of ≥10 Mbps optical downlinks from a 3U CubeSat to aportable 30 cm optical ground telescope. The payload is jointly developed by MIT and NASA ARC, and is on schedule for a 2020 bus integration and 2021 launch. The mission purpose is to reduce risk to its follow-up in 2022, called CLICK-B/C, that plans to demonstrate ≥20 Mbps intersatellite optical crosslinks and precision ranging between two 3U CubeSats. The 1.4U CLICK-A payload will fly on a Blue Canyon Technologies 3U bus inserted into a 400 km orbit. The payload will demonstrate both the transmitter optoelectronics and the fine-pointing system based on a MEMS fast steering mirror, which enables precision pointing of its 1300 μrad full-width half-maximum (FWHM) downlink beam with anestimated error of 136.9 μrad (3-σ) for a pointing loss of -0.134 dB (3-σ) at the time of link closure. We present recent test results of the CLICK-A payload, including results from thermal-vacuum testing, beam characterization, functional testing of the transmitter, and thermal analyses including measurement of deformation due to the thermal loading of the MEMS FSM

Lack of microbiological concordance between bone and non-bone specimens in chronic osteomyelitis: an observational study

BACKGROUND: Prognosis of chronic osteomyelitis depends heavily on proper identification and treatment of the bone-infecting organism. Current knowledge on selecting the best specimen for culture is confusing, and many consider that non-bone specimens are suitable to replace bone cultures. This paper compares the microbiology of non-bone specimens with bone cultures, taking the last as the diagnostic gold standard. METHODS: Retrospective observational analysis of 50 patients with bacterial chronic osteomyelitis in a 750-bed University-based hospital. RESULTS: Concordance between both specimens for all etiologic agents was 28%, for Staphylococcus aureus 38%, and for organisms other than S. aureus 19%. The culture of non-bone specimens to identify the causative organisms in chronic osteomyelitis produced 52% false negatives and 36% false positives when compared against bone cultures. CONCLUSIONS: Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the bone

Ceftriaxone bone penetration in patients with septic non-union of the tibia

SummaryObjectivesA main determinant of clinical response to antibiotic treatment is drug concentration at the infected site. Data on ceftriaxone (CFX) bone penetration are lacking. We measured CFX concentrations in infected bone to verify their relationship with pharmacodynamic microbiological markers.MethodsEleven patients undergoing debridement for septic non-union of the tibia and receiving intravenous CFX were studied. Plasma and bone specimens were collected intraoperatively at a variable interval after CFX administration. Drug concentrations were measured by high-performance liquid chromatography with ultraviolet detection (HPLC-UV) method.ResultsBone samples were extracted at a mean of 3.3h (range 1.5–8.0h) since the start of CFX infusion. The mean±standard deviation intraoperative CFX plasma concentration was 128.4±30.8mg/l; the corresponding bone concentrations were 9.6±3.4mg/l (7.8%) in the cortical compartment and 30.8±8.6mg/l (24.3%) in the cancellous compartment. The mean 24-h area under the concentration–time curve (AUC24) values were 176.8±62.2 h*mg/l in cortical bone and 461.5±106.8 h*mg/l in cancellous bone. The time above the minimum inhibitory concentration (T>MIC) was 24h in all compartments. The estimated mean free AUC/MIC ratios and T>MIC were 140 and 24.4h, respectively, in cancellous bone and 42.4 and 21h, respectively, in cortical bone.ConclusionsCFX bone penetration was poor (<15%) in the cortical compartment and satisfactory in the more vascularized cancellous bone. The T>MIC and AUC/MIC ratios suggest that CFX achieves a satisfactory pharmacokinetic exposure in cancellous bone as far as pathogens with a MIC of <0.5 are concerned. However, considering free drug concentrations, pharmacokinetic/pharmacodynamic targets may not be fully achieved in cortical bone. As antibiotic exposure can be suboptimal in the infected cortical compartment, and drug penetration may be impaired into necrotic bone and sequesters, a radical surgical removal of purulent and necrotic tissues appears essential to shorten treatment duration and to prevent treatment failures

Interference management for moving networks in ultra-dense urban scenarios

The number of users relying on broadband wireless connectivity while riding public transportation vehicles is increasing significantly. One of the promising solutions is to deploy moving base stations on public transportation vehicles to form moving networks (MNs) that serve these vehicular users inside the vehicles. In this study, we investigated the benefits and challenges in deploying MNs in ultra-dense urban scenarios. We identified that the key challenge limiting the performance of MNs in ultra-dense urban scenarios is inter-cell interference, which is exacerbated by the urban canyon effects. To address this challenge, we evaluated different inter-cell interference coordination and multi-antenna interference suppression techniques for MNs. We showed that in using MNs together with effective interference management approaches, the quality of service for users in vehicles can be significantly improved, with negligible impacts on the performance of regular outdoor users