Pre-equilibrium emission vs. formation of 46Ti∗

In the NUCL-EX extensive research program on competition between pre-equilibrium and equilibrated source emission, the reactions 16O+30Si, 18O+28Si and 19F+27Al in the range between 100 and 130 MeV have been measured with the GARFIELD + RCo array at Legnaro National Laboratory. The complete analysis is being performed on an event-by-event basis. The experimental data are compared to the theoretical predictions, where events are generated by numerical codes based on pre-equilibrium and/or statistical models and then filtered through a software replica of the setup. Effects related to the entrance channel and to the colliding ions cluster nature are emphasized through differences between the predictions and the experimental data. After a general introduction on the theoretical basis and on the experimental campaign, some results based on statistical models will be presented in this contribution

Study of LCP emissions from 46Ti∗

The study of pre-equilibrium emitted particles is an useful tool to examine nuclear clustering; in order to study how possible cluster structures affect nuclear reactions, the NUCL-EX collaboration (INFN, Italy) is carrying out an extensive research campaign on pre-equilibrium emission of light charged particles from hot nuclei. In this framework, the reactions 16O + 30Si, 18O + 28Si and 19F + 27Al at 7 MeV/u have been measured at the GARFIELD+RCo array in Legnaro National Laboratories. After a general introduction on the experimental campaign, this contribution will focus on the analysis results obtained so far; effects related to the entrance channel and to the colliding ions cluster nature are emphasized through differences between the theoretical predictions and the experimental data

LCP Fast Emission vs. Evaporation from 46Ti∗

The study of pre-equilibrium (or fast) emitted particles is a useful tool to examine nuclear clustering; to study how possible cluster structures affect nuclear reactions, the NUCL-EX Collaboration (INFN, Italy) is carrying out an extensive research campaign on pre-equilibrium emission of light charged particles from hot nuclei. In this framework, the reactions 16O+30Si, 18O+28Si and 19F + 27Al at 7MeV/u have been measured at the GARFIELD+RCo array in Legnaro National Laboratories. After a general introduction on the experimental campaign, this contribution will focus on the analysis results obtained so far; effects related to the entrance channel and to the colliding ions cluster nature are emphasized through differences between the theoretical predictions and the experimental data

16O+65 Cu and 19F+62 Ni at 16 AMeV reaction mechanisms comparison: Pre-equilibrium vs. clustering

Cluster structure effects in nuclei have been investigated looking to the pre-equilibrium particles emitted in the 16O+65Cu and 19F+62Ni reactions at the same beam velocity of 16 AMeV which lead to the same 81Rb* compound nucleus. Despite the slight difference in excitation energies, the same fast emission should be expected from the two systems; unless major effects induced by the projectile’s cluster structure, which should influence the pre-equilibrium α-particle production during the non-equilibrium stage, are present. The experimental data have been collected with the GARFIELD+RCo apparatus at Laboratori Nazionali di Legnaro. In this contribution we report on the preliminary spectra of light-charged particles, obtained in coincidence with evaporation residues, and their comparison with the results obtained from model calculations

Machine learning aplicado a remote sensing: aplicaciones en gobernanza digital para el desarrollo sustentable

El presente trabajo muestra las problemáticas abordadas mediante tecnologías de Machine Learning aplicadas a Remote Sensing, las que pueden servir de soporte a la gobernanza digital para el desarrollo sustentable. Para ello se realiza una revisión bibliográfica de la utilización de estas dos tecnologías con el fin de mostrar cuáles son los avances alcanzados en el área, en qué se está trabajando y cuáles son las aplicaciones relacionadas con la gobernanza electrónica para el desarrollo sustentable.Trabajo presentado por el Instituto de Investigación y Transferencia en Tecnología (ITT

Penetrance of Hypertrophic Cardiomyopathy in Sarcomere Protein Mutation Carriers

[Abstract] Background. Predictive genetic screening of relatives of patients with hypertrophic cardiomyopathy (HCM) caused by sarcomere protein (SP) gene mutations is current standard of care, but there are few data on long-term outcomes in mutation carriers without HCM. Objectives. The aim of this study was to determine the incidence of new HCM diagnosis in SP mutation carriers. Methods. This was a retrospective analysis of adult and pediatric SP mutation carriers identified during family screening who did not fulfill diagnostic criteria for HCM at first evaluation. Results. The authors evaluated 285 individuals from 156 families (median age 14.2 years [interquartile range: 6.8 to 31.6 years], 141 [49.5%] male individuals); 145 (50.9%) underwent cardiac magnetic resonance (CMR). Frequency of causal genes was as follows: MYBPC3 n = 123 (43.2%), MYH7 n = 69 (24.2%), TNNI3 n = 39 (13.7%), TNNT2 n = 34 (11.9%), TPM1 n = 9 (3.2%), MYL2 n = 6 (2.1%), ACTC1 n = 1 (0.4%), multiple mutations n = 4 (1.4%). Median follow-up was 8.0 years (interquartile range: 4.0 to 13.3 years) and 86 (30.2%) patients developed HCM; 16 of 50 (32.0%) fulfilled diagnostic criteria on CMR but not echocardiography. Estimated HCM penetrance at 15 years of follow-up was 46% (95% confidence interval [CI]: 38% to 54%). In a multivariable model adjusted for age and stratified for CMR, independent predictors of HCM development were male sex (hazard ratio [HR]: 2.91; 95% CI: 1.82 to 4.65) and abnormal electrocardiogram (ECG) (HR: 4.02; 95% CI: 2.51 to 6.44); TNNI3 variants had the lowest risk (HR: 0.19; 95% CI: 0.07 to 0.55, compared to MYBPC3). Conclusions. Following a first negative screening, approximately 50% of SP mutation carriers develop HCM over 15 years of follow-up. Male sex and an abnormal ECG are associated with a higher risk of developing HCM. Regular CMR should be considered in long-term screening

Isospin diffusion measurement from the direct detection of a Quasi-Projectile remnant

The neutron-proton (n-p) equilibration process in 48Ca+40Ca at 35 MeV/nucleon bombarding energy is experimentally estimated by means of the isospin transport ratio. Experimental data are collected with a subset of the FAZIA telescope array, which permits us to determine the Z and N of detected fragments. For the first time, the quasiprojectile (QP) evaporative channel is compared with the QP breakup one in a homogeneous and consistent way, pointing to comparable n-p equilibration, which suggests a close interaction time between projectile and target independently of the exit channel. Moreover, in the QP evaporative channel n-p equilibration is compared with the prediction of the antisymmetrized molecular dynamics model coupled with the GEMINI statistical model as an afterburner, showing a higher probability of proton and neutron transfers in the simulation with respect to the experimental data.This work required the use of a lot of computation time for the production of the simulated data. We would like to thank the GARR Consortium for the kind use of the cloud computing infrastructure on the platform cloud.garr.it. We would like to thank also the INFN-CNAF for the use of its cloud computing infrastructure. A. Ono was supported by JSPS KAK-ENHI Grant No. JP17K05432. This work was also supported by the National Research Foundation of Korea (NRF)(Grant No. 2018R1A5A1025563).Departamento de Física Aplicad

Cardiac myosin binding protein-C variants in paediatric-onset hypertrophic cardiomyopathy: natural history and clinical outcomes

Background: Variants in the cardiac myosin-binding protein C gene (MYBPC3) are a common cause of hypertrophic cardiomyopathy (HCM) in adults and have been associated with late-onset disease, but there are limited data on their role in paediatric-onset HCM. The objective of this study was to describe natural history and clinical outcomes in a large cohort of children with HCM and pathogenic/likely pathogenic (P/LP) MYBPC3 variants. / Methods and results: Longitudinal data from 62 consecutive patients diagnosed with HCM under 18 years of age and carrying at least one P/LP MYBPC3 variant were collected from a single specialist referral centre. The primary patient outcome was a major adverse cardiac event (MACE). Median age at diagnosis was 10 (IQR: 2–14) years, with 12 patients (19.4%) diagnosed in infancy. Forty-seven (75%) were boy and 31 (50%) were probands. Median length of follow-up was 3.1 (IQR: 1.6–6.9) years. Nine patients (14.5%) experienced an MACE during follow-up and five (8%) died. Twenty patients (32.3%) had evidence of ventricular arrhythmia, including 6 patients (9.7%) presenting with out-of-hospital cardiac arrest. Five-year freedom from MACE for those with a single or two MYBPC3 variants was 95.2% (95% CI: 78.6% to 98.5%) and 68.4% (95% CI: 40.6% to 88.9%), respectively (HR 4.65, 95% CI: 1.16 to 18.66, p=0.03). / Conclusions: MYBPC3 variants can cause childhood-onset disease, which is frequently associated with life-threatening ventricular arrhythmia. Clinical outcomes in this cohort vary substantially from aetiologically and genetically mixed paediatric HCM cohorts described previously, highlighting the importance of identifying specific genetic subtypes for clinical management of childhood HCM