Morphological assessment of non-human primate models of osteoarthritis: Comparisons of HR-MRI with CT arthrography (CTA)

International audienc

Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life

International audienc

Wrinkling and crumpling in twisted few and multilayer CVD graphene: High density of edge modes influencing Raman spectra

International audienceRichness and complexity of Raman spectra related to graphene materials is established from years to decades, with, among others: the well-known G, D, 2D,... bands plus a plethora of weaker bands related to disorder behavior, doping, stress, crystal orientation or stacking information. Herein, we report on how to detect crumpling effects in Raman spectra, using a large variety of few and multilayer graphene. The main finding is that these crumples enhance the G band intensity like it does with twisted bi layer graphene. We updated the D over G band intensity ratio versus G band width plot, which is generally used to disentangle point and linear defects origin, by reporting surface defects created by crumples. Moreover, we report for the first time on the existence 23 resonant additional bands at 633 nm. We attribute them to edge modes formed by high density of crumples. We use Raman plots (2D bands versus G band positions and widths) to gain qualitative information about the way layers are stacked

Comparison of HR-MRI with µCT arthrography for the morphological assessment of non-human primate models of osteoarthritis

International audienc

Comparison of HR-MRI with µCT arthrography for the morphological assessment of non-human primate models of osteoarthritis

International audienc

Morphological assessment of non-human primate models of osteoarthritis using HR-MRI and μCT arthrography

International audienc

Morphological assessment of non-human primate models of osteoarthritis using HR-MRI and µCT arthrography

International audienc

Morphological assessment of non-human primate models of osteoarthritis using HR-MRI and µCT arthrography

International audienc

Managing catastrophic events by wearable mobile systems

Proetex is a European Integrated Project dedicated to micro- and nano-technology-based wearable equipment for emergency operators. During the first year of work, a careful analysis of several emergency scenarios has been carried out and has resulted in the design of a complete “smart” uniform for fire-fighters and emergency rescuers. These garments aim at monitoring both physiological parameters, position and posture of the operators and the presence of external potential sources of danger and to send these data to a remote coordinating unit. In the following, the main issues of the design flow will be described and discussed

Thyroid hormone receptor α is a molecular switch of cardiac function between fetal and postnatal life

Thyroid hormones are involved in the regulation of many physiological processes and regulate gene transcription by binding to their nuclear receptors TRα and TRβ. In the absence of triiodothyronine (T3), the unliganded receptors (aporeceptors) do bind DNA and repress the transcription of target genes. The role of thyroid hormone aporeceptors as repressors was observed in hypothyroid adult mice, but its physiological relevance in nonpathological hypothyroid conditions remained to be determined. Here we show that, in the normal mouse fetus, TRα aporeceptors repress heart rate as well as the expression of TRβ and several genes encoding ion channels involved in cardiac contractile activity. Right after birth, when T3 concentration sharply increases, liganded TRα (holoreceptors) turn on the expression of some of these same genes concomitantly with heart rate increase. These data describe a physiological situation under which conversion of TRα from apo-receptors into holo-receptors, upon changes in T3 availability, plays a determinant role in a developmental process