Estimator: An Effective and Scalable Framework for Transportation Mode Classification over Trajectories

Transportation mode classification, the process of predicting the class labels of moving objects transportation modes, has been widely applied to a variety of real world applications, such as traffic management, urban computing, and behavior study. However, existing studies of transportation mode classification typically extract the explicit features of trajectory data but fail to capture the implicit features that affect the classification performance. In addition, most of the existing studies also prefer to apply RNN-based models to embed trajectories, which is only suitable for classifying small-scale data. To tackle the above challenges, we propose an effective and scalable framework for transportation mode classification over GPS trajectories, abbreviated Estimator. Estimator is established on a developed CNN-TCN architecture, which is capable of leveraging the spatial and temporal hidden features of trajectories to achieve high effectiveness and efficiency. Estimator partitions the entire traffic space into disjointed spatial regions according to traffic conditions, which enhances the scalability significantly and thus enables parallel transportation classification. Extensive experiments using eight public real-life datasets offer evidence that Estimator i) achieves superior model effectiveness (i.e., 99% Accuracy and 0.98 F1-score), which outperforms state-of-the-arts substantially; ii) exhibits prominent model efficiency, and obtains 7-40x speedups up over state-of-the-arts learning-based methods; and iii) shows high model scalability and robustness that enables large-scale classification analytics.Comment: 12 pages, 8 figure

Fair Multiple-bank E-cash in the Standard Model

Multiple-bank e-cash (electronic cash) model allows users and merchants to open their accounts at different banks which are monitored by the Center Bank. Some multiple-bank e-cash systems were proposed in recent years. However, prior implementations of multiple-bank e-cash all require the random oracle model idealization in their security analysis. We know some schemes are secure in the random oracle model, but are trivially insecure under any instantiation of the oracle. In this paper, based on the automorphic blind signature, the Groth-Sahai proof system and a new group blind signature, we construct a fair multiple-bank e-cash scheme. The new scheme is proved secure in the standard model and provides the following functionalities, such as owner tracing, coin tracing, identification of the double spender and signer tracing. In order to sign two messages at once, we extend Ghadafi\u27s group blind signature to a new group blind signature. The new signature scheme may be of independent interest

Research on Bi-level Cooperative Robust Planning of Distributed Renewable Energy in Incremental Distribution Network Considering Demand Response

The paper constructs a two-level collaborative planning model for incremental distribution network considering demand response and distributed renewable energy access. In the upper model, the goal is to minimize the investment cost of the distribution network, and the lower model takes the system's operating cost optimally, fully considers the uncertainty of renewable energy output, and introduces robust optimization to solve it. It can be seen from the simulation results that the consideration of demand response in the distribution network planning is conducive to delaying investment costs, enhancing power user load flexibility, and effectively avoiding load shedding and other problems. The research results lay the foundation for the feasibility of demand response resources participating in power grid plannin

Checklist of vascular plant species in Huangshui River Basin of Qinghai Province, China

The Huangshui River Basin is one of the most important water sources in the Qinghai Province and is of great importance for ecological protection measures, agricultural irrigation and tourism. Based on previous studies and fieldwork related to plant species in China, this study presents comprehensive data on vascular plants distributed in the Huangshui River Basin of Qinghai Province.Ethical Compliance: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.Data Access Statement: Research data supporting this publication are available from the repository at located at https://www.scidb.cn/en/anonymous/QUpuZVEz.Conflict of Interest declaration: The authors declare that they have NO affiliations with or involvement in any organisation or entity with any financial interest in the subject matter or materials discussed in this manuscript.The checklist of plants includes ferns, gymnosperms and angiosperms, covering three phyla, five classes, 49 orders, 139 families, 709 genera and 2,382 species. It includes numerous Asteraceae, Gramineae, Rosaceae and Fabaceae along with statistical data on the number of species distributed in different regions. The dataset presented in this article provides important background information on vascular plants in the Huangshui River Basin and, therefore, plays a crucial role in the protection and management of plant resources in this region

Effect of magnesium sulfate on cerebral vasospasm in the treatment of aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis

IntroductionThe use of magnesium sulfate for treating aneurysmal subarachnoid hemorrhage (aSAH) has shown inconsistent results across studies. To assess the impact of magnesium sulfate on outcomes after aSAH, we conducted a systematic review and meta-analysis of relevant randomized controlled trials.MethodsPubMed, Embase, and the Cochrane Library were searched for relevant literature on magnesium sulfate for aSAH from database inception to March 20, 2023. The primary outcome was cerebral vasospasm (CV), and secondary outcomes included delayed cerebral ischemia (DCI), secondary cerebral infarction, rebleeding, neurological dysfunction, and mortality.ResultsOf the 558 identified studies, 16 comprising 3,503 patients were eligible and included in the analysis. Compared with control groups (saline or standard treatment), significant differences were reported in outcomes of CV [odds ratio (OR) = 0.61, p = 0.04, 95% confidence interval (CI) (0.37–0.99)], DCI [OR = 0.57, p = 0.01, 95% CI (0.37–0.88)], secondary cerebral infarction [OR = 0.49, p = 0.01, 95% CI (0.27–0.87)] and neurological dysfunction [OR = 0.55, p = 0.04, 95% CI (0.32–0.96)] after magnesium sulfate administration, with no significant differences detected in mortality [OR = 0.92, p = 0.47, 95% CI (0.73–1.15)] and rebleeding [OR = 0.68, p = 0.55, 95% CI (0.19–2.40)] between the two groups.ConclusionThe superiority of magnesium sulfate over standard treatments for CV, DCI, secondary cerebral infarction, and neurological dysfunction in patients with aSAH was demonstrated. Further randomized trials are warranted to validate these findings with increased sample sizes

ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients

Hematopoiesis is a finely regulated process in vertebrates under both homeostatic and stress conditions. By whole exome sequencing, we studied the genomics of acute lymphoblastic leukemia (ALL) patients who needed multiple red blood cell (RBC) transfusions after intensive chemotherapy treatment. ARHGEF12, encoding a RhoA guanine nucleotide exchange factor, was found to be associated with chemotherapy-induced anemia by genome-wide association study analyses. A single nucleotide polymorphism (SNP) of ARHGEF12 located in an intron predicted to be a GATA1 binding site, rs10892563, is significantly associated with patients who need RBC transfusion (P=3.469E-03, odds ratio 5.864). A luciferase reporter assay revealed that this SNP impairs GATA1-mediated trans-regulation of ARHGEF12, and quantitative polymerase chain reaction studies confirmed that the homozygotes status is associated with an approximately 61% reduction in ARHGEF12 expression (P=0.0088). Consequently, erythropoiesis was affected at the pro-erythroblast phases. The role of ARHGEF12 and its homologs in erythroid differentiation was confirmed in human K562 cells, mouse 32D cells and primary murine bone marrow cells. We further demonstrated in zebrafish by morpholino-mediated knockdown and CRISPR/Cas9-mediated knockout of arhgef12 that its reduction resulted in erythropoiesis defects. The p38 kinase pathway was affected by the ARHGEF12-RhoA signaling in K562 cells, and consistently, the Arhgef12-RhoA-p38 pathway was also shown to be important for erythroid differentiation in zebrafish as active RhoA or p38 readily rescued the impaired erythropoiesis caused by arhgef12 knockdown. Finally, ARHGEF12-mediated p38 activity also appeared to be involved in phenotypes of patients of the rs10892563 homozygous genotype. Our findings present a novel SNP of ARHGEF12 that may involve ARHGEF12-RhoA-p38 signaling in erythroid regeneration in ALL patients after chemotherapy

Charge transport in hybrid platinum/molecule/graphene single molecule junctions.

The single molecule conductance of hybrid platinum/alkanedithiol/graphene junctions has been investigated with a focus on understanding the influence of employing two very different contact types. We call this an "anti-symmetric" configuration, with the two different contacts here being platinum and graphene, which respectively provide very different electronic coupling to the alkanedithiol bridge. The conductance of these junctions is experimentally investigated by using a non-contact scanning tunneling microscopy (STM) based method called the I(s) technique. These experimental determinations are supported by density functional theory (DFT) calculations. These alkanedithiol bridging molecules conduct electric current through the highest occupied molecular orbital (HOMO), and junctions formed with Pt/graphene electrode pairs are slightly more conductive than those formed with Au/graphene electrodes which we previously investigated. This is consistent with the lower work function of gold than that of platinum. The measured conductance decays exponentially with the length of the molecular bridge with a low tunneling decay constant, which has a similar value for Pt/graphene and Au/graphene electrode pairs, respectively. These new results underline the importance of the coupling asymmetry between the two electrodes, more than the type of the metal electrode itself. Importantly, the tunneling decay constant is much lower than that of alkanedithiols with the symmetrical equivalent, i.e. identical metal electrodes. We attribute this difference to the relatively weak van der Waals coupling at the graphene interface and the strong bond dipole at the Pt-S interface, resulting in a decrease in the potential barrier at the interface

A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis

Transcriptional regulation plays a critical role in the life cycle of Mycobacterium smegmatis and its related species, M. tuberculosis, the causative microbe for tuberculosis. However, the key transcriptional factors involved in broad regulation of diverse genes remain to be characterized in mycobacteria. In the present study, a TetR-like family transcriptional factor, Ms6564, was characterized in M. smegmatis as a master regulator. A conserved 19 bp-palindromic motif was identified for Ms6564 binding using DNaseI footprinting and EMSA. A total of 339 potential target genes for Ms6564 were further characterized by searching the M. smegmatis genome based on the sequence motif. Notably, Ms6564 bound with the promoters of 37 cell cycle and DNA damage/repair genes and regulated positively their expressions. The Ms6564-overexpressed recombinant strain yielded 5-fold lower mutation rates and mutation frequencies, whereas deletion of Ms6564 resulted in ∼5-fold higher mutation rates for the mutant strain compared with the wild-type strain. These findings suggested that Ms6564 may function as a global regulator and might be a sensor necessary for activation of DNA damage/repair genes