Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy

Vascular endothelial injury in diabetes mellitus (DM) is the major cause of vascular disease, which is closely related to the occurrence and development of a series of vascular complications and has a serious negative impact on a patient’s health and quality of life. The primary function of normal vascular endothelium is to function as a barrier function. However, in the presence of DM, glucose and lipid metabolism disorders, insulin resistance, inflammatory reactions, oxidative stress, and other factors cause vascular endothelial injury, leading to vascular endothelial lesions from morphology to function. Recently, numerous studies have found that autophagy plays a vital role in regulating the progression of vascular endothelial injury. Therefore, this article compares the morphology and function of normal and diabetic vascular endothelium and focuses on the current regulatory mechanisms and the important role of autophagy in diabetic vascular endothelial injury caused by different signal pathways. We aim to provide some references for future research on the mechanism of vascular endothelial injury in DM, investigate autophagy’s protective or injurious effect, and study potential drugs using autophagy as a target

Influence of cutterhead system structure on load distribution and life of main bearing

Service life of main bearing represents the life of tunnel boring machine (TBM) system. It is affected by the raceway load distribution which is related to the stiffness of supporting structure, as the main bearing is not rigid. To improve the service life of main bearing, the influences of key parameters of cutterhead system structure on the uniformity of load distribution are revealed, and the structure is optimized based on that. A finite element method (FEM) model of main structure is constructed to get the accurate load distribution in the main bearing for service life calculation, and the springs with nonlinear stiffness are employed to simulate the relationships between rock and cutters on the basis of Colorado School of Mines (CSM) method. Compared with the original structure, it shows that the uniformity of axial force distribution on thrust raceway increases obviously, and the service life of the main bearing is extended

High Power and High Capacity 3D-Structured TiO2 Electrodes forLithium-Ion Microbatteries

An on-chip compatible method to fabricate high energy density TiO2 thin film electrodes on 3D-structured silicon substrates was demonstrated. 3D-structured electrodes are fabricated by combining reactive ion etching (RIE) with low pressure chemical vapor deposition (LPCVD), enabling accurate control of the aspect ratio of substrates and the subsequent deposition of TiO2 thin film electrodes onto these structured substrates. The prepared 3D-TiO2 electrodes exhibit a current-dependent increase in storage capacity of a factor up to 16 as compared to conventional planar electrodes. In addition, these 3D electrodes also reveal excellent power and cycling performance. This work demonstrates that LPCVD is capable of depositing homogeneous film electrodes on highly structured substrates and the prepared 3D-electrodes also shows significant improve in storage capacity and power density

An evolving network model with community structure

Many social and biological networks consist of communities—groups of nodes within which connections are dense, but between which connections are sparser. Recently, there has been considerable interest in designing algorithms for detecting community structures in real-world complex networks. In this paper, we propose an evolving network model which exhibits community structure. The network model is based on the inner-community preferential attachment and inter-community preferential attachment mechanisms. The degree distributions of this network model are analysed based on a mean-field method. Theoretical results and numerical simulations indicate that this network model has community structure and scale-free properties

Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis

Background: This study aims to evaluate the efficacy and safety of Danggui Niantong Decoction (DGNT) systematically on gout treating.Methods: This study was registered in PROSPERO, and the registration number was CRD42021271607. By the end of December, 2022, literature research was conducted among eight electronic databases. Main results of this study were blood uric acid (BUA) and Creactive protein (CRP). Secondary outcomes were erythrocyte sedimentation rate (ESR), serum creatinine (Scr), urinary protein quantified at 24 h (Upro), and interleukin-8 (IL-8). Study screening, data collection, as well as quality assessment were performed by two reviewers independently, and analysis was completed using Stata (SE15.0) and Review Manager (5.4).Results: A total number of 13 studies were included in our meta-analysis (n = 1,094 participants). Results showed DGNT combined with conventional western medicine (CWM) was more effective than WM alone in BUA (weighted mean differences (WMD) = −3.49, 95% confidence interval (CI) [−50.36, −32.59], p = 0.000), CRP (WMD = −41.48, 95% CI [−4.32, −2.66], p = 0.017), ESR (WMD = −6.23, 95% CI [−9.28, −3.17], p = 0.019), Scr (WMD = −18.64, 95% CI [−23.09, −14.19], p = 0.001), Upro (WMD = −0.72, 95% CI [−0.91, −0.53], p = 0.000), and IL-8 (WMD = −4.77, 95% CI [−11.48, 1.94], p = 0.000). None of the adverse effects noted were severe, and no life-threatening event was reported.Conclusion: This study shows that DGNT combined with CWM seems to have an effective clinical therapeutic potential. In addition, it also provides a scientific basis for better clinical application of DGNT in the future.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271607; Identifier: PROSPERO, CRD42021271607

Nursing intervention among patients with hypertension to improved medication adherence

Background ：Hypertension is a public health problem in many countries.Cardiovascular disease is the leading cause of death worldwide, with hypertensionbeing a major influencing factor. The prevalence increases with increasing age. In thenear future, the hypertensive population will also increase rapidly due to the increase inthe elderly population. Hypertension is associated with cardiovascular disease. Nursinginterventions have the potential to promote medication adherence in patients withhypertension.Aim:The purpose of this systematic review is to describe the available informationon the. Effectiveness of nursing interventions to improve medication adherence inpatients with hypertension.Methods： A systematic review was conducted. May 2022 and April 2023, adatabase search was conducted in English and Arabic in PubMed, EBSCO and otherdatabases during 2012-2022. Randomized controlled trials were taken into account. Thesystematic review followed the criteria of Roy's adaptation theory.Results: Out of the 260 articles found, 9 studies were selected for inclusion. Amultifaceted nurse-led intervention (telehealth devices, remote reminders, motivationalsessions) had demonstrated significant reductions in blood pressure (especially systolicblood pressure) in the intervention group. Nurse-led interventions also influencedhypertension awareness, self-awareness, and self-control. a positive effect on improvingmedication adherence, the Positive effects on lower salt intake, consumption of fruits andvegetables, and medication adherence were also described.Conclusions :Nurse-led nursing interventions have a positive effect on improvingmedication adherence in patients with hypertension.For patients with hypertension, futureresearch is needed to further investigate the effects of e-health, personalized activelearning, community activities, and other interventions on medication adherence. Inaddition, future studies could focus on measuring actual blood pressure and identifyingchanges associated with educational interventions.Keywords:nursing interventions；hypertension;medication adherence

Nursing intervention among patients with hypertension to improved medication adherence

Background ：Hypertension is a public health problem in many countries.Cardiovascular disease is the leading cause of death worldwide, with hypertensionbeing a major influencing factor. The prevalence increases with increasing age. In thenear future, the hypertensive population will also increase rapidly due to the increase inthe elderly population. Hypertension is associated with cardiovascular disease. Nursinginterventions have the potential to promote medication adherence in patients withhypertension.Aim:The purpose of this systematic review is to describe the available informationon the. Effectiveness of nursing interventions to improve medication adherence inpatients with hypertension.Methods： A systematic review was conducted. May 2022 and April 2023, adatabase search was conducted in English and Arabic in PubMed, EBSCO and otherdatabases during 2012-2022. Randomized controlled trials were taken into account. Thesystematic review followed the criteria of Roy's adaptation theory.Results: Out of the 260 articles found, 9 studies were selected for inclusion. Amultifaceted nurse-led intervention (telehealth devices, remote reminders, motivationalsessions) had demonstrated significant reductions in blood pressure (especially systolicblood pressure) in the intervention group. Nurse-led interventions also influencedhypertension awareness, self-awareness, and self-control. a positive effect on improvingmedication adherence, the Positive effects on lower salt intake, consumption of fruits andvegetables, and medication adherence were also described.Conclusions :Nurse-led nursing interventions have a positive effect on improvingmedication adherence in patients with hypertension.For patients with hypertension, futureresearch is needed to further investigate the effects of e-health, personalized activelearning, community activities, and other interventions on medication adherence. Inaddition, future studies could focus on measuring actual blood pressure and identifyingchanges associated with educational interventions.Keywords:nursing interventions；hypertension;medication adherence