58 research outputs found
First Jump of Microgel: Actuation Speed Enhancement by Elastic Instability
Swelling-induced snap-buckling in a 3D micro hydrogel device, inspired by the
insect-trapping action of Venus flytrap, makes it possible to generate
astonishingly fast actuation. We demonstrate that elastic energy is effectively
stored and quickly released from the device by incorporating elastic
instability. Utilizing its rapid actuation speed, the device can even jump by
itself upon wetting.Comment: 4 pages, 3 figure
Trace element zinc and skin disorders
Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use
An essential role for Stat3 in regulating IgG immune complexâinduced pulmonary inflammation
Growing evidence suggests that transcription factor signal transducer and activator of transcription (Stat) 3 may play an important regulatory role during inflammation. However, the function of Stat3 in acute lung injury (ALI) is largely unknown. In the current study, by using an adenoviral vector expressing a dominantânegative Stat3 isoform (AdâStat3âEVA), we determined the role of Stat3 in IgG immune complex (IC)âinduced inflammatory responses and injury in the lung from C57BL/6J mice. We show that IgG ICâinduced DNA binding activity of Stat3 in the lung was significantly inhibited by Stat3âEVA. We demonstrate that both lung vascular permeability (albumin leak) and lung myeloperoxidase accumulation in the AdâStatâEVA treated mice were substantially reduced when compared with values in mice receiving control virus (AdâGFP) during the injury. Furthermore, intratracheal administration of AdâStat3âEVA caused significant decreases in the contents of neutrophils, inflammatory cytokines (TNFâα and ILâ6), chemokines [keratinocyte cellâderived chemokine, macrophage inflammatory protein (MIP)â1α, and MIPâ1ÎČ], and complement component C5a in bronchoalveolar lavage fluids. Using Stat3âspecific small interfering RNA, we show that knocking down Stat3 expression in alveolar macrophages (MHâS cells) significantly reduced the production of proinflammatory mediators on IgG IC stimulation. These data suggest that Stat3 plays an essential role in the pathogenesis of IgG ICâinduced ALI by mediating the acute inflammatory responses in the lung and alveolar macrophages.âTang, H., Yan, C., Cao, J., Sarma, J. V., Haura, E. B., Wu, M., Gao, H. An essential role for Stat3 in regulating IgG immune complexâinduced pulmonary inflammation. FASEB J. 25, 4292â4300 (2011). www.fasebj.orgPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154500/1/fsb2fj11187955.pd
Comparison on different strategies for treatments of hypertensive hemorrhage in the basal ganglia region with a volume of 25 to 35ml
Population response of intestinal microbiota to acute Vibrio alginolyticus infection in half-smooth tongue sole (Cynoglossus semilaevis)
IntroductionVibriosis causes enormous economic losses of marine fish. The present study investigated the intestinal microbial response to acute infection of half-smooth tongue sole with different-dose Vibrio alginolyticus within 72âh by metagenomic sequencing.MethodsThe inoculation amount of V. alginolyticus for the control, low-dose, moderate-dose, and high-dose groups were 0, 8.5âĂâ101, 8.5âĂâ104, and 8.5âĂâ107 cells/g respectively, the infected fish were farmed in an automatic seawater circulation system under a relatively stable temperature, dissolved oxygen and photoperiod, and 3â~â6 intestinal samples per group with high-quality DNA assay were used for metagenomics analysis.ResultsThe acute infections with V. alginolyticus at high, medium, and low doses caused the change of different-type leukocytes at 24âh, whereas the joint action of monocytes and neutrophils to cope with the pathogen infection only occurred in the high-dose group at 72âh. The metagenomic results suggest that a high-dose V. alginolyticus infection can significantly alter the intestinal microbiota, decrease the microbial α-diversity, and increase the bacteria from Vibrio and Shewanella, including various potential pathogens at 24âh. High-abundance species of potential pathogens such as V. harveyii, V. parahaemolyticus, V. cholerae, V. vulnificus, and V. scophthalmi exhibited significant positive correlations with V. alginolyticus. The function analysis revealed that the high-dose inflection group could increase the genes closely related to pathogen infection, involved in cell motility, cell wall/ membrane/envelope biogenesis, material transport and metabolism, and the pathways of quorum sensing, biofilm formation, flagellar assembly, bacterial chemotaxis, virulence factors and antibiotic resistances mainly from Vibrios within 72âh.DiscussionIt indicates that the half-smooth tongue sole is highly likely to be a secondary infection with intestinal potential pathogens, especially species from Vibrio and that the disease could become even more complicated because of the accumulation and transfer of antibiotic-resistance genes in intestinal bacteria during the process of V. alginolyticus intensified infection
Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis
Background: This study aims to evaluate the efficacy and safety of Danggui Niantong Decoction (DGNT) systematically on gout treating.Methods: This study was registered in PROSPERO, and the registration number was CRD42021271607. By the end of December, 2022, literature research was conducted among eight electronic databases. Main results of this study were blood uric acid (BUA) and Creactive protein (CRP). Secondary outcomes were erythrocyte sedimentation rate (ESR), serum creatinine (Scr), urinary protein quantified at 24Â h (Upro), and interleukin-8 (IL-8). Study screening, data collection, as well as quality assessment were performed by two reviewers independently, and analysis was completed using Stata (SE15.0) and Review Manager (5.4).Results: A total number of 13 studies were included in our meta-analysis (n = 1,094 participants). Results showed DGNT combined with conventional western medicine (CWM) was more effective than WM alone in BUA (weighted mean differences (WMD) = â3.49, 95% confidence interval (CI) [â50.36, â32.59], p = 0.000), CRP (WMD = â41.48, 95% CI [â4.32, â2.66], p = 0.017), ESR (WMD = â6.23, 95% CI [â9.28, â3.17], p = 0.019), Scr (WMD = â18.64, 95% CI [â23.09, â14.19], p = 0.001), Upro (WMD = â0.72, 95% CI [â0.91, â0.53], p = 0.000), and IL-8 (WMD = â4.77, 95% CI [â11.48, 1.94], p = 0.000). None of the adverse effects noted were severe, and no life-threatening event was reported.Conclusion: This study shows that DGNT combined with CWM seems to have an effective clinical therapeutic potential. In addition, it also provides a scientific basis for better clinical application of DGNT in the future.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271607; Identifier: PROSPERO, CRD42021271607
CCAAT/Enhancer-Binding Protein Îł Is a Critical Regulator of IL-1ÎČ-Induced IL-6 Production in Alveolar Epithelial Cells
CCAAT/enhancer binding protein Îł (C/EBPÎł) is a member of the C/EBP family of transcription factors, which lacks known activation domains. C/EBPÎł was originally described as an inhibitor of C/EBP transactivation potential. However, previous study demonstrates that C/EBPÎł augments the C/EBPÎČ stimulatory activity in lipopolysaccharide induction of IL-6 promoter in a B lymphoblast cell line. These data indicate a complexing functional role for C/EBPÎł in regulating gene expression. Furthermore, the expression and function of C/EBPÎł during inflammation are still largely unknown. In this study, we demonstrate that C/EBPÎł activation was induced by IL-1ÎČ treatment in lung epithelial cells. Importantly, we demonstrate for the first time that C/EBPÎł plays a critical role in regulating IL-1ÎČ-induced IL-6 expression in both mouse primary alveolar type II epithelial cells and a lung epithelial cell line, MLE12. We further provide the evidence that C/EBPÎł inhibits IL-6 expression by inhibiting C/EBPÎČ but not NF-ÎșB stimulatory activity in MLE12 cells. These findings suggest that C/EBPÎł is a key transcription factor that regulates the IL-6 expression in alveolar epithelial cells, and may play an important regulatory role in lung inflammatory responses
Comparison on different strategies for treatments of hypertensive hemorrhage in the basal ganglia region with a volume of 25 to 35ml Comparação de diferentes estratégias no tratamento da hemorragia hipertensiva da região dos gùnglios da base com volume de 25 a 35ml
PURPOSE: To compare curative effect of different treatments for hypertensive cerebral hemorrhage of 25 to 35ml. METHODS: In this study, 595 cases were enrolled and grouped regarding treatments including conservative treatment, evacuation with microinvasive craniopuncture technique within 6h and 6-48h after the attack. RESULTS: After follow up for three months after the attack, the assessment based on the Activity of Daily Living (ADL) indicated no significant difference among conservative treatment and surgical interventions (p>0.05). However, surgical interventions showed advantages of shorter hospitalization, quick removal of hematoma and obvious reduction of cost. CONCLUSION: The microinvasive craniopuncture technique to drain the hematoma within 6-48h may be a good way in treating hypertensive hemorrhage of basal ganglia region.<br>OBJETIVO: Comparar o efeito curativo de diferentes tratamentos da hemorragia hipertensiva cerebral de 25 a 35ml. MĂTODOS: Foram analisados 595 casos agrupados segundo tratamento conservador e evacuação com tĂ©cnica de punção transcraniana dentro de 6h ou de 6 Ă s 48h do inĂcio do quadro clĂnico. RESULTADOS: O seguimento apĂłs trĂȘs meses e avaliado pelo Escore de Atividade de Vida DiĂĄrio, indicou que nĂŁo houve diferenças significantes entre os tratamentos conservador e cirĂșrgico (p>0.05) O tratamento cirĂșrgico mostrou vantagem com hospitalização mais curta e redução de custos. CONCLUSĂO: A tĂ©cnica de punção transcraniana para drenagem de hematoma dos nĂșcleos da base pode ser uma boa alternativa de tratamento
Dynamic Weighting Network for Person Re-Identification
Recently, hybrid Convolution-Transformer architectures have become popular due to their ability to capture both local and global image features and the advantage of lower computational cost over pure Transformer models. However, directly embedding a Transformer can result in the loss of convolution-based features, particularly fine-grained features. Therefore, using these architectures as the backbone of a re-identification task is not an effective approach. To address this challenge, we propose a feature fusion gate unit that dynamically adjusts the ratio of local and global features. The feature fusion gate unit fuses the convolution and self-attentive branches of the network with dynamic parameters based on the input information. This unit can be integrated into different layers or multiple residual blocks, which will have varying effects on the accuracy of the model. Using feature fusion gate units, we propose a simple and portable model called the dynamic weighting network or DWNet, which supports two backbones, ResNet and OSNet, called DWNet-R and DWNet-O, respectively. DWNet significantly improves re-identification performance over the original baseline, while maintaining reasonable computational consumption and number of parameters. Finally, our DWNet-R achieves an mAP of 87.53%, 79.18%, 50.03%, on the Market1501, DukeMTMC-reID, and MSMT17 datasets. Our DWNet-O achieves an mAP of 86.83%, 78.68%, 55.66%, on the Market1501, DukeMTMC-reID, and MSMT17 datasets
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