Filter and nested-lattice code design for fading MIMO channels with side-information

Linear-assignment Gel'fand-Pinsker coding (LA-GPC) is a coding technique for channels with interference known only at the transmitter, where the known interference is treated as side-information (SI). As a special case of LA-GPC, dirty paper coding has been shown to be able to achieve the optimal interference-free rate for interference channels with perfect channel state information at the transmitter (CSIT). In the cases where only the channel distribution information at the transmitter (CDIT) is available, LA-GPC also has good (sometimes optimal) performance in a variety of fast and slow fading SI channels. In this paper, we design the filters in nested-lattice based coding to make it achieve the same rate performance as LA-GPC in multiple-input multiple-output (MIMO) channels. Compared with the random Gaussian codebooks used in previous works, our resultant coding schemes have an algebraic structure and can be implemented in practical systems. A simulation in a slow-fading channel is also provided, and near interference-free error performance is obtained. The proposed coding schemes can serve as the fundamental building blocks to achieve the promised rate performance of MIMO Gaussian broadcast channels with CDIT or perfect CSITComment: submitted to IEEE Transactions on Communications, Feb, 200

Clean relaying aided cognitive radio under the coexistence constraint

We consider the interference-mitigation based cognitive radio where the primary and secondary users can coexist at the same time and frequency bands, under the constraint that the rate of the primary user (PU) must remain the same with a single-user decoder. To meet such a coexistence constraint, the relaying from the secondary user (SU) can help the PU's transmission under the interference from the SU. However, the relayed signal in the known dirty paper coding (DPC) based scheme is interfered by the SU's signal, and is not "clean". In this paper, under the half-duplex constraints, we propose two new transmission schemes aided by the clean relaying from the SU's transmitter and receiver without interference from the SU. We name them as the clean transmitter relaying (CT) and clean transmitter-receiver relaying (CTR) aided cognitive radio, respectively. The rate and multiplexing gain performances of CT and CTR in fading channels with various availabilities of the channel state information at the transmitters (CSIT) are studied. Our CT generalizes the celebrated DPC based scheme proposed previously. With full CSIT, the multiplexing gain of the CTR is proved to be better (or no less) than that of the previous DPC based schemes. This is because the silent period for decoding the PU's messages for the DPC may not be necessary in the CTR. With only the statistics of CSIT, we further prove that the CTR outperforms the rate performance of the previous scheme in fast Rayleigh fading channels. The numerical examples also show that in a large class of channels, the proposed CT and CTR provide significant rate gains over the previous scheme with small complexity penalties.Comment: 30 page

Multi-user lattice coding for the multiple-access relay channel

This paper considers the multi-antenna multiple access relay channel (MARC), in which multiple users transmit messages to a common destination with the assistance of a relay. In a variety of MARC settings, the dynamic decode and forward (DDF) protocol is very useful due to its outstanding rate performance. However, the lack of good structured codebooks so far hinders practical applications of DDF for MARC. In this work, two classes of structured MARC codes are proposed: 1) one-to-one relay-mapper aided multiuser lattice coding (O-MLC), and 2) modulo-sum relay-mapper aided multiuser lattice coding (MS-MLC). The former enjoys better rate performance, while the latter provides more flexibility to tradeoff between the complexity of the relay mapper and the rate performance. It is shown that, in order to approach the rate performance achievable by an unstructured codebook with maximum-likelihood decoding, it is crucial to use a new K-stage coset decoder for structured O-MLC, instead of the one-stage decoder proposed in previous works. However, if O-MLC is decoded with the one-stage decoder only, it can still achieve the optimal DDF diversity-multiplexing gain tradeoff in the high signal-to-noise ratio regime. As for MS-MLC, its rate performance can approach that of the O-MLC by increasing the complexity of the modulo-sum relay-mapper. Finally, for practical implementations of both O-MLC and MS-MLC, practical short length lattice codes with linear mappers are designed, which facilitate efficient lattice decoding. Simulation results show that the proposed coding schemes outperform existing schemes in terms of outage probabilities in a variety of channel settings.Comment: 32 pages, 5 figure

CCN2 Enhances Resistance to Cisplatin-Mediating Cell Apoptosis in Human Osteosarcoma

Osteosarcoma (OS) is the most common form of malignant bone tumor and is an aggressive malignant neoplasm exhibiting osteoblastic differentiation. Cisplatin is one of the most efficacious antitumor drugs for osteosarcoma patients. However, treatment failures are common due to the development of chemoresistance. CCN2 (also known as CTGF), is a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells. However, the effect of CCN2 in cisplatin-mediated chemotherapy is still unknown. Here, we found that CCN2 was upregulated in human osteosarcoma cells after treatment with cisplatin. Moreover, overexpression of CCN2 increased the resistance to cisplatin-mediated cell apoptosis. In contrast, reduction of CCN2 by CCN2 shRNA promoted the chemotherapeutic effect of cisplatin. We also found that CCN2 provided resistance to cisplatin-induced apoptosis through upregulation of Bcl-xL and survivin. Knockdown of Bcl-xL or survivin removed the CCN2-mediated resistance to apoptosis induced by cisplatin. On the other hand, CCN2 also promoted FAK, MEK, and ERK survival signaling pathways to enhance tumor survival during cisplatin treatment. In a mouse xenograft model, overexpression of CCN2 promoted resistance to cisplatin. However, knockdown of CCN2 increased the therapeutic effect of cisplatin. Therefore, our data suggest that CCN2 might be a critical oncogene of human osteosarcoma for cisplatin-resistance and supported osteosarcoma cell growth in vivo and in vitro

Liquid biopsy genotyping in lung cancer: ready for clinical utility?

Liquid biopsy is a blood test that detects evidence of cancer cells or tumor DNA in the circulation. Despite complicated collection methods and the requirement for technique-dependent platforms, it has generated substantial interest due, in part, to its potential to detect driver oncogenes such as epidermal growth factor receptor (EGFR) mutants in lung cancer. This technology is advancing rapidly and is being incorporated into numerous EGFR tyrosine kinase inhibitor (EGFR-TKI) development programs. It appears ready for integration into clinical care. Recent studies have demonstrated that biological fluids such as saliva and urine can also be used for detecting EGFR mutant DNA through application other user-friendly techniques. This review focuses on the clinical application of liquid biopsies to lung cancer genotyping, including EGFR and other targets of genotype-directed therapy and compares multiple platforms used for liquid biopsy