Assessment of the validity and reliability of the Vietnamese version of the Breast Cancer Screening Beliefs Questionnaire

Objective: The aim of this study was to evaluate the cultural adaptability and psychometric properties of the Vietnamese version of the Breast Cancer Screening Beliefs Questionnaire (BCSBQ). Methods: A total of 253 women aged 18 years and older with no history of breast cancer was included in the analysis. Results: Confirmatory factor analysis showed an adequate fit for the hypothesized three-factor structure of the original version of the BCSBQ. The results indicated that the frequency of women’s breast cancer screening practices and their educational levels were significantly associated with “Attitudes towards general check-ups”. Demonstrating the Cronbach’s α of the three subscales ranged between 0.79 and 0.85 while the corrected item-total correlations for the hypothesized subscales ranged from 0.38 to 0.74, constituted a result which indicated that the Vietnamese version of the BCSBQ had satisfactory validity and internal consistency. Conclusions: The Vietnamese version of the BCSBQ is a culturally appropriate, valid, and reliable instrument for examining the beliefs, knowledge, and attitudes about breast cancer and breast cancer screening practices among Vietnamese women living in Australia

Towards topological mapping with vision-based simultaneous localization and map building

Although the theory of Simultaneous Localization and Map Building (SLAM) is well developed, there are many challenges to overcome when incorporating vision sensors into SLAM systems. Visual sensors have different properties when compared to range finding sensors and therefore require different considerations. Existing vision-based SLAM algorithms extract point landmarks, which are required for SLAM algorithms such as the Kalman filter. Under this restriction, the types of image features that can be used are limited and the full advantages of vision not realized. This thesis examines the theoretical formulation of the SLAM problem and the characteristics of visual information in the SLAM domain. It also examines different representations of uncertainty, features and environments. It identifies the necessity to develop a suitable framework for vision-based SLAM systems and proposes a framework called VisionSLAM, which utilizes an appearance-based landmark representation and topological map structure to model metric relations between landmarks. A set of Haar feature filters are used to extract image structure statistics, which are robust against illumination changes, have good uniqueness property and can be computed in real time. The algorithm is able to resolve and correct false data associations and is robust against random correlation resulting from perceptual aliasing. The algorithm has been tested extensively in a natural outdoor environment

Mapping and direct valuation: Do they give equivalent EQ-5D-5L index scores?

© 2015 Luo et al. Objective: Utility values of health states defined by health-related quality of life instruments can be derived from either direct valuation ('valuation-derived') or mapping ('mapping-derived'). This study aimed to compare the utility-based EQ-5D-5L index scores derived from the two approaches as a means to validating the mapping function developed by van Hout et al for the EQ-5D-5L instrument. Methods: This was an observational study of 269 breast cancer patients whose EQ-5D-5L index scores were derived from both methods. For comparing discriminatory ability and responsiveness to change, multivariable regression models were used to estimate the effect sizes of various health indicators on the index scores. Agreement and test-retest reliability were examined using intraclass correlation coefficient (ICC). Whenever appropriate, the 90 % confidence intervals (90 % CI) were compared to predefined equivalence margins. Results: The mean difference in and ICC between the valuation- and mapping-derived EQ-5D-5L index scores were 0.015 (90 % CI = 0.006 to 0.024) and 0.915, respectively. Discriminatory ability and responsiveness of the two indices were equivalent in 13 of 15 regression analyses. However, the mapping-derived index score was lower than the valuation-derived index score in patients experiencing extreme health problems, and the test-retest reliability of the former was lower than the latter, for example, their ICCs differed by 0.121 (90 % CI = 0.051 to 0.198) in patients who reported no change in performance status in the follow-up survey. Conclusion: This study provided the first evidence supporting the validity of the mapping function for converting EQ-5D-5L profile data into a utility-based index score.published_or_final_versio

Effects of orthographic consistency and homophone density on Chinese spoken word recognition

Studies of alphabetic language have shown that orthographic knowledge influences phonological processing during spoken word recognition. This study utilized the Event-Related Potentials (ERPs) to differentiate two types of phonology-to-orthography (P-to-O) mapping consistencies in Chinese, namely homophone density and orthographic consistency. The ERP data revealed an orthographic consistency effect in the frontal-centrally distributed N400, and a homophone density effect in central-posteriorly distributed late positive component (LPC). Further source analyses using the standardized low-resolution electromagnetic tomography (sLORETA) demonstrated that the orthographic effect was not only localized in the frontal and temporal-parietal regions for phonological processing, but also in the posterior visual cortex for orthographic processing, while the homophone density effect was found in middle temporal gyrus for lexical-semantic selection, and in the temporal-occipital junction for orthographic processing. These results suggest that orthographic information not only shapes the nature of phonological representations, but may also be activated during on-line spoken word recognition

The feedback consistency effect in Chinese character recognition:evidence from a psycholinguistic norm

Researchers have demonstrated the importance of phonology in literacy acquisition and in visual word recognition. For example, the spelling-to-sound consistency effect has been observed in visual word recognition tasks, in which the naming responses are faster and more accurate for words with the same letters that also have the same pronunciation (e.g. -ean is always pronounced /in/, as in lean, dean, and bean). In addition, some studies have reported a much less intuitive feedback consistency effect when a rime can be spelled in different ways (e.g. /ip/ in heap and deep) in lexical decision tasks. Such findings suggest that, with activation flowing back and forth between orthographic and phonological units during word processing, any inconsistency in the mappings between orthography and phonology should weaken the stability of the feedback loop, and, thus, should delay recognition. However, several studies have failed to show reliable feedback consistency in printed word recognition. One possible reason for this is that the feedback consistency is naturally confounded with many other variables, such as orthographic neighborhood or bigram frequency, as these variables are difficult to tease apart. Furthermore, there are challenges in designing factorial experiments that perfectly balance lexical stimuli on all factors besides feedback consistency. This study aims to examine the feedback consistency effect in reading Chinese characters by using a normative data of 3,423 Chinese phonograms. We collected the lexical decision time from 180 college students. A linear mixed model analysis was used to examine the feedback consistency effect by taking into account additional properties that may be confounded with feedback consistency, including character frequency, number of strokes, phonetic combinability, semantic combinability, semantic ambiguity, phonetic consistency, noun-to-verb ratios, and morphological boundedness. Some typical effects were observed, such as the more frequent and familiar a character, the faster one can decide it is a real character. More importantly, the linear mixed model analysis revealed a significant feedback consistency effect while controlling for other factors, which indicated that the pronunciation of phonograms might accommodate the organization of Chinese orthographic representation. Our study disentangled the feedback consistency from the many other factors, and supports the view that phonological activation would reverberate to orthographic representation in visual word recognition

Identification of Essential Residues in the Type II Hsp40 Sis1 That Function in Polypeptide Binding

Sis1 is an essential yeast Type II Hsp40 protein that assists cytosolic Hsp70 Ssa1 in the facilitation of processes that include translation initiation, the prevention of protein aggregation, and proteasomal protein degradation. An essential function of Sis1 and other Hsp40 proteins is the binding and delivery of non-native polypeptides to Hsp70. How Hsp40s function as molecular chaperones is unknown. The crystal structure of a Sis1 fragment that retains peptide-binding activity suggests that Type II Hsp40s utilize hydrophobic residues located in a solvent-exposed patch on carboxyl-terminal domain I to bind non-native polypeptides. To test this model, amino acid residues Val-184, Leu-186, Lys-199, Phe-201, Ile-203, and Phe-251, which form a depression in carboxyl-terminal domain I, were mutated, and the ability of Sis1 mutants to support cell viability and function as molecular chaperones was examined. We report that Lys-199, Phe-201, and Phe-251 are essential for cell viability and required for Sis1 polypeptide binding activity. Sis1 I203T could support normal cell growth, but when purified it exhibited severe defects in chaperone function. These data identify essential residues in Sis1 that function in polypeptide binding and help define the nature of the polypeptide-binding site in Type II Hsp40 proteins