Multiple, Bilateral Fibroepithelial Polyps Causing Acute Renal Failure in a Gastric Cancer Patient

We report a case of primary fibroepithelial polyps (FEPs) in the middle of both ureters in a patient with advanced gastric cancer and acute renal failure. Ureteral FEPs are rare benign lesions, and multiple, bilateral lesions are extremely rare. To our knowledge, this report is the seventh case of bilateral FEPs in the literature. Our case has clinical implications because FEPs should be considered as a cause of ureteral obstruction inducing acute renal failure in advanced gastric cancer

Ischemic and Bleeding Events Associated with Thrombocytopenia and Thrombocytosis after Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction

The early and late ischemic and bleeding clinical outcomes according to baseline platelet count after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) remain unclear. Overall, 10,667 patients from the Cardiovascular Risk and identification of potential high-risk population in AMI (COREA-AMI) I and II registries were classified according to the following universal criteria on baseline platelet counts: (1) moderate to severe thrombocytopenia (platelet \u3c 100 K/µL, n = 101), (2) mild thrombocytopenia (platelet = 100~149 K/µL, n = 631), (3) normal reference (platelet = 150~450 K/µL, n = 9832), and (4) thrombocytosis (platelet \u3e 450 K/µL, n = 103). The primary endpoint was the occurrence of major adverse cardiovascular events (MACE). The secondary outcome was Bleeding Academic Research Consortium (BARC) 2, 3, and 5 bleeding. After adjusting for confounders, the moderate to severe thrombocytopenia (HR, 2.03; 95% CI, 1.49–2.78); p \u3c 0.001), mild thrombocytopenia (HR, 1.15; 95% CI, 1.01–1.34; p = 0.045), and thrombocytosis groups (HR, 1.47; 95% CI, 1.07–2.03; p = 0.019) showed higher 5-year MACE rates than the normal reference. In BARC 2, 3, and 5 bleeding outcomes, the bleedings rates were higher than the normal range in the moderate to severe thrombocytopenia (HR, 2.18; 95% CI, 1.36–3.49; p = 0.001) and mild thrombocytopenia (HR, 1.41; 95% CI, 1.12–1.78; p = 0.004) groups. Patients with AMI had higher 5-year MACE rates after PCI if they had lower- or higher-than-normal platelet counts. Thrombocytopenia revealed higher early and late bleeding rates whereas thrombocytosis showed long-term bleeding trends, although these trends were not statistically significant

Impaired Design Fluency Is a Marker of Pathological Cognitive Aging; Results from the Korean Longitudinal Study on Health and Aging

ObjectiveaaWe investigated neuropsychological markers that can be used to discriminate pathological cognitive aging from normal cognitive aging. MethodsaaWe administered frontal lobe function tests including the Wisconsin Card Sorting Test (WCST), digit span test, lexical fluency test, fixed condition design fluency test, and Trail Making Test B (TMT-B) to 92 individuals with pathological cognitive aging (PCA) and 222 individuals with normal cognitive aging (NCA). We examined the main effects of participants ’ diagnoses (PCA, NCA) and age (65-69 years old, 70-74 years old and 75 years old or over) on their test performance using multivariate analysis of variance. ResultsaaThe main effects of both the diagnosis (F=2.860, p=0.002) and the age group (F=2.484, p<0.001) were significant. The PCA group showed lower performance on the backward digit span test (F=14.306, p<0.001), fixed condition design fluency test (F=8.347, p=0.004) and also exhibited perseverative errors in the WCST (F=4.19, p=0.042) compared with the NCA group. The main effect of the diagnosis on the backward digit span test and the fixed condition design fluency test remained significant after Bonferroni correction

Physical-Layer Security Improvement with Reconfigurable Intelligent Surfaces for 6G Wireless Communication Systems

Recently, reconfigurable intelligent surfaces (RISs) have received much interest from both academia and industry due to their flexibility and cost-effectiveness in adjusting the phase and amplitude of wireless signals with low-cost passive reflecting elements. In particular, many RIS-aided techniques have been proposed to improve both data rate and energy efficiency for 6G wireless communication systems. In this paper, we propose a novel RIS-based channel randomization (RCR) technique for improving physical-layer security (PLS) for a time-division duplex (TDD) downlink cellular wire-tap network which consists of a single base station (BS) with multiple antennas, multiple legitimate pieces of user equipment (UE), multiple eavesdroppers (EVEs), and multiple RISs. We assume that only a line-of-sight (LOS) channel exists among the BS, the RISs, and the UE due to propagation characteristics of tera-hertz (THz) spectrum bands that may be used in 6G wireless communication systems. In the proposed technique, each RIS first pseudo-randomly generates multiple reflection matrices and utilizes them for both pilot signal duration (PSD) in uplink and data transmission duration (DTD) in downlink. Then, the BS estimates wireless channels of UE with reflection matrices of all RISs and selects the UE that has the best secrecy rate for each reflection matrix generated. It is shown herein that the proposed technique outperforms the conventional techniques in terms of achievable secrecy rates

The complete chloroplast genome sequence of limestone endemic, Zabelia tyaihyoni (Caprifoliaceae), in Korea

The first complete chloroplast genome sequence of Korean limestone endemic, Zabelia tyaihyoni, was reported in this study. The plastome size was 156,449 bp in total length, with one large single copy (LSC; 89,242 bp), one small single copy (SSC; 17,331 bp), and two inverted repeat (IR) regions (IRa and IRb, each with 24,938 bp). The overall GC content was 38.3% and the genome contained 128 genes, including 83 protein-coding with 3 pseudogenes (two ycf2 and accD), 37 transfer RNA and 8 ribosomal RNA genes. Phylogenetic analysis of 21 representative plastomes within the Caprifoliaceae suggests that Zabelia formed a monophyletic clade with 100% bootstrap value and Z. tyaihyoni was closely related to Z. biflora and Z. corymbosa

Analysis of the effect of aging on the response to hypoxia by cDNA microarray

Little is known about the detail of hypoxia-responsive gene expression patterns in advanced age, even though aging is thought to be partially associated with a decreased response to hypoxia. In the present study, we identified several hypoxia-inducible genes and investigated the effect of aging on hypoxic gene expression profiles using cDNA microarray analysis of young/old human diploid fibroblasts. Of 7458 genes in the microarray, we found that genes involved in angiogenesis, defense against oxidative stress, and transcription regulation are severely impaired in senescent cell, which is consistent with the fact that aged cells have attenuated responses to various stimuli. (C) 2003 Elsevier Ireland Ltd. All rights reserved.