High performance integrated photonic circuit based on inverse design method

The basic indexes of all-optical integrated photonic circuits include high-density integration, ultrafast response and ultra-low energy consumption. Traditional methods mainly adopt conventional micro/nano-structures. The overall size of the circuit is large, usually reaches hundreds of microns. Besides, it is difficult to balance the ultrafast response and ultra-low energy consumption problem, and the crosstalk between two traditional devices is difficult to overcome. Here, we propose and experimentally demonstrate an approach based on inverse design method to realize a high-density, ultrafast and ultra-low energy consumption integrated photonic circuit with two all-optical switches controlling the input states of an all-optical XOR logic gate. The feature size of the whole circuit is only 2.5 μm × 7 μm, and that of a single device is 2 μm × 2 μm. The distance between two adjacent devices is as small as 1.5 μm, within wavelength magnitude scale. Theoretical response time of the circuit is 150 fs, and the threshold energy is within 10 fJ/bit. We have also considered the crosstalk problem. The circuit also realizes a function of identifying two-digit logic signal results. Our work provides a new idea for the design of ultrafast, ultra-low energy consumption all-optical devices and the implementation of high-density photonic integrated circuits

Edge states in plasmonic meta-arrays

Photonic edge states provide a novel platform to control and enhance light-matter interactions. Recently, it becomes increasing popular to generate such localized states using the bulk-edge correspondence of topological photonic crystals. While the topological approach is elegant, the design and fabrication of these complex photonic topological crystals is tedious. Here, we report a simple and effective strategy to construct and steer photonic edge state in a plasmonic meta-array, which just requires a small number of plasmonic nanoparticles to form a simple lattice. To demonstrate the idea, different lattice configurations, including square, triangular, and honeycomb lattices of meta-arrays, are fabricated and measured by using an ultrahigh spatial resolution photoemission electron microscopy. The properties of edge states depend on the geometric details such as the row and column number of the lattice, as well as the gap distance between the particles. Moreover, numerical simulations show that the excited edge states can be used for the generation of the quantum entanglement. This work not only provides a new platform for the study of nanoscale photonic devices, but also open a new way for the fundamental study of nanophotonics based on edge states

Effects of hormone replacement therapy on glucose and lipid metabolism in peri- and postmenopausal women with a history of menstrual disorders

Abstract Background Previous studies have indicated that women with a history of menstrual disorders have an increased risk of metabolic and cardiovascular diseases. This has been attributed to the high proportion of polycystic ovary syndrome (PCOS) among this group. The favorable effects of hormone replacement therapy (HRT) on serum lipid profiles and glucose homeostasis in postmenopausal women is widely accepted. Whether HRT can also show positive effects on metabolic homeostasis in menopausal women with prior menstrual disorders (a putative PCOS phenotype) has not been reported yet. The aim of the study was to compare the effects of HRT on glucose and lipid metabolism in peri- and postmenopausal women with prior menstrual disorders and controls who did not have prior menstrual disorders. Methods A retrospective multicenter study was conducted including 595 peri- and postmenopausal women who received HRT at four hospitals in the Zhejiang Province from May 31, 2010 to March 8, 2021. Participants were divided into the Normal menstruation group and the Menstrual disorders group according to their prior usual menstrual cycle pattern. Glucose and lipid metabolism indicators were assessed at baseline and after HRT. The results were compared between and within the groups, and data from peri- and postmenopausal women were analyzed separately. Results HRT significantly decreased fasting insulin and homeostasis model assessment of insulin resistance in perimenopausal users, and fasting plasma glucose levels in postmenopausal users with prior menstrual disorders, compared with baseline. Furthermore, HRT decreased low-density lipoprotein cholesterol, total cholesterol, fasting insulin, fasting plasma glucose and homeostasis model assessment of insulin resistance in both peri- and postmenopausal controls, compared with baseline. Nevertheless, no significant differences were observed in any of the glucose or lipid metabolism indicators at baseline and follow-up, as well as changes from baseline levels between menopausal women with and without prior menstrual disorders. Conclusions HRT shows more obvious within-group improvements in glucose and lipid metabolism in controls, but there is no significant between-group difference. Further prospective studies are required for confirmation

Enhancing Weak-Signal Extraction for Single-Molecule Localization Microscopy

Single-molecule localization microscopy (SMLM) has been widely used in biological imaging due to its ultrahigh spatial resolution. However, due to the strategy of reducing photodamage to living cells, the fluorescence signals of emitters are usually weak and the detector noises become non-negligible, which leads to localization misalignments and signal losses, thus deteriorating the imaging capability of SMLM. Here, we propose an active modulation method to control the fluorescence of the probe emitters. It actually marks the emitters with artificial blinking character, which directly distinguishes weak signals from multiple detector noises. We demonstrated from simulations and experiments that this method improves the signal-to-noise ratio by about 10 dB over the non-modulated method and boosts the sensitivity of single-molecule localization down to −4 dB, which significantly reduces localization misalignments and signal losses in SMLM. This signal-noise decoupling strategy is generally applicable to the super-resolution system with versatile labeled probes to improve their imaging capability. We also showed its application to the densely labeled sample, showing its flexibility in super-resolution nanoscopy