Malignant biliary obstruction

<p>Age-standardized awareness, treated and controlled hypertension prevalence levels (95% CI) in urban (A) and rural (B) areas of Indonesia and (C) overall in men and women with hypertension.</p

Baseline characteristics of study population.

<p>Baseline characteristics of study population.</p

Additional file 2: of Prevalence of heart failure in Australia: a systematic review

Literature search history: a sample using Ovid MEDLINE. (DOC 63 kb

Multiple adjusted odds ratio (AOR) for hypertension (showing 95% CIs) by education status in urban and rural areas in men and women.

<p>Multiple adjusted odds ratio (AOR) for hypertension (showing 95% CIs) by education status in urban and rural areas in men and women.</p

Prevalence of hypertension by age, sex and socio-economic development in Indonesian men and women, IFLS 2007.

<p>Prevalence of hypertension by age, sex and socio-economic development in Indonesian men and women, IFLS 2007.</p

Multiple adjusted mean systolic and diastolic blood pressure (showing 95% CI) across different categories of Body Mass Index and waist circumference in Indonesian men and women ≥ 40 years of age.

<p>Multiple adjusted mean systolic and diastolic blood pressure (showing 95% CI) across different categories of Body Mass Index and waist circumference in Indonesian men and women ≥ 40 years of age.</p

Stepwise logistic regression analysis of factors associated with uncontrolled hypertension.

<p>Stepwise logistic regression analysis of factors associated with uncontrolled hypertension.</p

FLP-1 neuropeptides modulate sensory and motor circuits in the nematode <i>Caenorhabditis elegans</i>

<div><p>Parasitic nematodes infect over one quarter of the population worldwide, causing morbidity in over one billion people. Current anthelmintic drugs are beginning to lose effectiveness due to the presence of resistant strains. We are interested in the role of neuropeptides, which regulate behaviors in all organisms, as another possible target for anthelmintic drugs. FMRFamide-related peptides (FaRPs) are a family of neuropeptides that are conserved throughout the animal kingdom. In particular, nematodes contain the largest family of FaRPs identified thus far and many of these FaRPs are identical among different nematode species; FaRPs in nematodes are collectively referred to as FLPs (<u>F</u>MRFamide-<u>l</u>ike <u>p</u>eptides). However, little is known about the function of these FLPs. We are using the non-parasitic nematode <i>Caenorhabditis elegans</i> as a model for examining FLPs in nematodes. <i>C</i>. <i>elegans</i> contains at least 31 <i>flp</i> genes that encode 72 potential FLPs. Among the <i>flp</i> genes, <i>flp-1</i> is one of the few that is universally found in nematodes. FLP-1 neuropeptides were previously reported to be involved in sensory and motor functions. However, previous alleles of <i>flp-1</i> also disrupted a neighboring gene, <i>daf-10</i>. To understand the phenotypes of <i>flp-1</i>, new alleles that specifically disrupt <i>flp-1</i> were characterized. The previously reported locomotory and egg-laying defects were found to be due to loss of <i>flp-1</i>, while the osmolarity defect is due to loss of <i>daf-10</i>. In addition, loss of <i>flp-1</i> and <i>daf-10</i> both cause several phenotypes that increase in severity in the double mutants by disrupting different neurons in the neural circuits.</p></div

Loss of <i>flp-1</i> causes multiple defects.

<p>Loss of <i>flp-1</i> causes multiple defects.</p