The Influence of the Idea of Progress on the Curriculum Theories of Experimentalism, Essentialism, and Reconstructionism

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Transitions in the morphological features, habitat use, and diet of young-of-the-year goosefish (Lophius americanus)

This study was designed to improve our understanding of transitions in the early life history and the distribution, habitat use, and diets for young-of-the-year (YOY) goosefish (Lophius americanus) and, as a result, their role in northeastern U.S. continental shelf ecosystems. Pelagic juveniles (>12 to ca. 50 mm total length [TL]) were distributed over most portions of the continental shelf in the Middle Atlantic Bight, Georges Bank, and into the Gulf of Maine. Most individuals settled by 50−85 mm TL and reached approximately 60−120 mm TL by one year of age. Pelagic YOY fed on chaetognaths, hyperiid amphipods, calanoid copepods, and ostracods, and benthic YOY had a varied diet of fishes and benthic crustaceans. Goosefish are widely scattered on the continental shelf in the Middle Atlantic Bight during their early life history and once settled, are habitat generalists, and thus play a role in many continental shelf habi

Attitudes of advanced Australian medical oncology trainees to rural practice

Aim: To identify the views of medical oncology trainees regarding rural training posts and rural practice overall, and to identify factors that may improve recruitment. Methods: A questionnaire was posted to all advanced oncology trainees in Australia in June 2006. The trainees were questioned on the perceived advantages and disadvantages of rural practice, their experience during previous rural rotations and potential incentives and barriers in recruiting trainees and specialist oncologists to regional and rural centers. Results: There was a 60% response rate. Of all participants 58% had considered rural practice. Those with a rural family background were more likely to have considered rural practice. Attitudes based on responses to listed disadvantages and advantages of rural practice were heterogenous. Lifestyle factors seemed to be of particular importance. Although there were perceived deficiencies in opportunities for professional education in rural oncology rotations, 94% felt their rotation had been a positive experience overall and 62% were more likely to consider a rural career following their rural rotation. Improving locum cover for leave was seen as a potential incentive by 97% trainees. Conclusion: Despite positive attitudes towards rural practice, many barriers exist preventing recruitment of medical oncology trainees to rural areas, in particular lifestyle factors that are difficult to modify. Factors that can be improved include improving access to clinical trials, enabling access to locum cover. Educational opportunities for current rural trainees need to be improved. Further study into potential incentives to enhance rural recruitment is required

Evidence of traffic-related pollutant control in soil-based Sustainable Urban Drainage Systems (SUDS)

SUDS are being increasingly employed to control highway runoff and have the potential to protect groundwater and surface water quality by minimising the risks of both point and diffuse sources of pollution. While these systems are effective at retaining polluted solids by filtration and sedimentation processes, less is known of the detail of pollutant behaviour within SUDS structures. This paper reports on investigations carried out as part of a co-ordinated programme of controlled studies and field measurements at soft-engineered SUDS undertaken in the UK, observing the accumulation and behaviour of traffic-related heavy metals, oil and PAHs. The field data presented were collected from two extended detention basins serving the M74 motorway in the south-west of Scotland. Additional data were supplied from an experimental lysimeter soil core leaching study. Results show that basin design influences pollutant accumulation and behaviour in the basins. Management and/or control strategies are discussed for reducing the impact of traffic-related pollutants on the aqueous environment

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest

BACKGROUND: The p53 oncosuppressor protein is a critical mediator of the response to injury in mammalian cells and is mutationally inactivated in the majority of lung malignancies. In this analysis, the effects of p53-deficiency were investigated in short-term primary cultures of murine bronchiolar Clara cells. Clara cells, isolated from gene-targeted p53-deficient mice, were compared to cells derived from wild type littermates. RESULTS: p53 null cultures displayed abnormal morphology; specifically, a high incidence of multinucleation, which increased with time in culture. Multinucleated cells were proficient in S phase DNA synthesis, as determined by BrdU incorporation. However, multinucleation did not reflect altered rates of S phase synthesis, which were similar between wild type and p53-/- cultures. Nucleation defects in p53-/- Clara cells associated with increased centrosome number, as determined by confocal microscopy of pericentrin-stained cultures, and may highlight a novel role of p53 in preserving genomic integrity in lung epithelial cells. Effects of p53-deficiency were also studied following exposure to DNA damage. A p53-dependent reduction in the BrdU index was observed in Clara cells following ionizing radiation. The reduction in BrdU index in wild type cells displayed serum-dependency, and occurred only in the absence of serum. Taken together, these findings demonstrate that in murine primary Clara cell culture, cell cycle arrest is a p53-mediated response to DNA damage, and that extracellular factors, such as serum, influence this response. CONCLUSION: These findings highlight functions of wild type p53 protein in bipolar spindle formation, centrosome regulation, and growth control in bronchiolar Clara cells

Coombs Hill: A Late Devonian fossil locality in the Witpoort Formation (Witteberg Group, South Africa)

Coombs Hill, a new fossil locality in the Witpoort Formation (Witteberg Group) of South Africa, preserves a record of Famennian (Late Devonian) life in Gondwana. Fossil plants collected at Coombs Hill are preliminarily assigned to several classes. Shelly invertebrates include a variety of bivalve mollusc forms, some of which appear to be preserved in life position. Biodiversity at Coombs Hill is comparable to that of the well-known Waterloo Farm lagerstätte in ordinal diversity, but exhibits differences in species composition. Ongoing taxonomic analysis will provide a rare window into the ecology of high-latitude environments during this pivotal stage of Earth history, which immediately preceded the end-Devonian extinction. Sandstone dominated sedimentary facies at Coombs Hill suggest a high-energy coastal marine setting, with brackish back-barrier estuarine/lagoonally derived fossiliferous mudstones. Exact stratigraphic placement within the Witpoort Formation is hampered by structural deformation, and precise age comparisons with Waterloo Farm are currently tenuous.Significance: A new fossil locality at Coombs Hill comprises the second known site with a suite of well preserved continental and marginal marine fossils from the Witpoort Formation, providing an exceptionally rare example of high-latitude life during the critical latest Devonian Famennian age. Several new plant taxa will be diagnosed from this locality, which also gives important insights into the morphology of Archaeopteris notosaria, South Africa’s earliest known tree. Discovery of a second palaeontologically significant site in the Witpoort Formation provides impetus for further structural and sedimentary facies analyses to align the unit with datable global eustatic events, and to clarify its internal chronology

Shocks and sonic booms in the intracluster medium: X-ray shells and radio galaxy activity

Motivated by hydrodynamic simulations, we discuss the X-ray appearance of radio galaxies embedded in the intracluster medium (ICM) of a galaxy cluster. We distinguish three regimes. In the early life of a powerful source, the entire radio cocoon is expanding supersonically and hence drives a strong shock into the ICM. Eventually, the sides of the cocoon become subsonic and the ICM is disturbed by the sonic booms of the jet's working surface. In both of these regimes, X-ray observations would find an X-ray shell. In the strong shock regime, this shell will be hot and relatively thin. However, in the weak shock (sonic-boom) regime, the shell will be approximately the same temperature as the undisturbed ICM. If a cooling flow is present, the observed shell may even be cooler than the undisturbed ICM due to the lifting of cooler material into the shell from the inner (cooler) regions of the cluster. In the third and final regime, the cocoon has collapsed and no well-defined X-ray shell will be seen. We discuss ways of estimating the power and age of the source once its regime of behavior has been determined.Comment: 4 pages, submitted for publication in Astrophysical Journal. Full paper (including figure) can be obtained from http://rocinante.Colorado.EDU/~chris/papers/xray_hydro.p

Load-shedding probabilities with hybrid renewable power generation and energy storage

The integration of renewable energy resources, such as solar and wind power, into the electric grid presents challengs partly due to the intermittency in the power output. These difficulties can be alleviated by effectively utilizing energy storage. We consider, as a case study, the integration of renewable resources into the electric power generation portfolio of an island off the coast of Southern California, Santa Catalina Island, and investigate the feasibility of replacing diesel generation entirely with solar photovoltaics (PV) and wind turbines, supplemented with energy storage. We use a simple storage model alongside a combination of renewables and varying load-shedding characterizations to determine the appropriate area of PV cells, number of wind turbines, and energy storage capacity needed to stay below a certain threshold probability for load-shedding over a pre-specified period of time and long-term expected fraction of time at load-shedding

Measuring Transit Signal Recovery in the Kepler Pipeline. III. Completeness of the Q1-Q17 DR24 Planet Candidate Catalogue, with Important Caveats for Occurrence Rate Calculations

With each new version of the Kepler pipeline and resulting planet candidate catalogue, an updated measurement of the underlying planet population can only be recovered with an corresponding measurement of the Kepler pipeline detection efficiency. Here, we present measurements of the sensitivity of the pipeline (version 9.2) used to generate the Q1-Q17 DR24 planet candidate catalog (Coughlin et al. 2016). We measure this by injecting simulated transiting planets into the pixel-level data of 159,013 targets across the entire Kepler focal plane, and examining the recovery rate. Unlike previous versions of the Kepler pipeline, we find a strong period dependence in the measured detection efficiency, with longer (>40 day) periods having a significantly lower detectability than shorter periods, introduced in part by an incorrectly implemented veto. Consequently, the sensitivity of the 9.2 pipeline cannot be cast as a simple one-dimensional function of the signal strength of the candidate planet signal as was possible for previous versions of the pipeline. We report on the implications for occurrence rate calculations based on the Q1-Q17 DR24 planet candidate catalog and offer important caveats and recommendations for performing such calculations. As before, we make available the entire table of injected planet parameters and whether they were recovered by the pipeline, enabling readers to derive the pipeline detection sensitivity in the planet and/or stellar parameter space of their choice.Comment: 8 pages, 5 figures, full electronic version of Table 1 available at the NASA Exoplanet Archive; accepted by ApJ May 2nd, 201