Debt here, there and everywhere

Let me sincerely thank all of the contributors to this forum and also the editors for facilitating the opportunity to have this conversation during a period when it was extremely difficult to meet in person. It is a real privilege to have one's work read so carefully and generously. Each contributor not only picks out key insights from my book, but also offers a provocation that take the ideas and themes developed in Spacing Debt elsewhere. This is scholarship at its most constructive, and as an author it is extremely rewarding to see my work used in this way. Spacing Debt aims to convince readers about the need to theorise debt spatially, while offering them a better understanding about the changes that have taken place in Ramallah, Palestine since 2008. It will appeal to readers interested in debt and finance, and those interested in the contemporary Levant. The book also seeks to be a resource for those thinking ‘elsewhere’, by which I mean scholars doing research with other concepts and/or in other geographical (and historical) contexts and/or in other disciplinary spaces (and across disciplines). The four responses demonstrate the novel and insightful outcomes that can result when such cross-cutting conversations succeed. Given the ubiquity of credit/debt spacings, but also their differences, interdisciplinary and cross-cultural ways of working are urgently needed in our contemporary worlds. In the remainder of my response, I want to continue the conversation with my four interlocutors by elaborating on some of themes in their responses

Creating a Local Usage Collection System: PySUSHI

Article discussing the design and implementation of a built-in-house usage collection system for electronic resource usage via release 4 and release 5 of the SUSHI protocol, as well as the design and integration of additional modules for the loading of manually downloaded COUNTER reports

Seeking Social Justice in the ACRL Framework

The scope of this article is to address the possibilities and challenges librarians concerned with social justice may face when working with the ACRL Framework. While the Framework recognizes that information emerges from varied contexts that reflect uneven distributions of power, privilege, and authority, it is missing a cogent statement that connects information literacy to social justice. In this article, authors concerned with social justice and civic engagement will share their reflections on the Framework from a critical pedagogical and social justice orientation

Creating a Local Usage Collection System: PySUSHI

Presentation discussing the design and implementation of a built-in-house usage collection system for electronic resource usage via release 4 and release 5 of the SUSHI protocol, as well as the design and integration of additional modules for the loading of manually downloaded COUNTER reports

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.

Despite the importance of the co-receptor PD-1 in T cell immunity, the upstream signaling pathway that regulates PD-1 expression has not been defined. Glycogen synthase kinase 3 (GSK-3, isoforms α and β) is a serine-threonine kinase implicated in cellular processes. Here, we identified GSK-3 as a key upstream kinase that regulated PD-1 expression in CD8(+) T cells. GSK-3 siRNA downregulation, or inhibition by small molecules, blocked PD-1 expression, resulting in increased CD8(+) cytotoxic T lymphocyte (CTL) function. Mechanistically, GSK-3 inactivation increased Tbx21 transcription, promoting enhanced T-bet expression and subsequent suppression of Pdcd1 (encodes PD-1) transcription in CD8(+) CTLs. Injection of GSK-3 inhibitors in mice increased in vivo CD8(+) OT-I CTL function and the clearance of murine gamma-herpesvirus 68 and lymphocytic choriomeningitis clone 13 and reversed T cell exhaustion. Our findings identify GSK-3 as a regulator of PD-1 expression and demonstrate the applicability of GSK-3 inhibitors in the modulation of PD-1 in immunotherapy.C.E.R. was supported by Wellcome Trust 092627/Z/10/Z, J.A.H. by an Irvington Institute Postdoctoral Fellowship from the Cancer Research Institute (New York), and E.I.Z. by a Leukemia and Lymphoma Society Scholar Award and a grant from the NIH AI081923. We thank Dr. Graham Lord (King’s College London) for the kind gift of the Ifng CNS-12 promoter.This is the final version of the article. It first appeared from Cell Press via http://dx.doi.org/10.1016/j.immuni.2016.01.01

The DEEP2 Galaxy Redshift Survey: Mean Ages and Metallicities of Red Field Galaxies at z ~ 0.9 from Stacked Keck/DEIMOS Spectra

As part of the DEEP2 galaxy redshift survey, we analyze absorption line strengths in stacked Keck/DEIMOS spectra of red field galaxies with weak to no emission lines, at redshifts 0.7 <= z <= 1. Comparison with models of stellar population synthesis shows that red galaxies at z ~ 0.9 have mean luminosity-weighted ages of the order of only 1 Gyr and at least solar metallicities. This result cannot be reconciled with a scenario where all stars evolved passively after forming at very high z. Rather, a significant fraction of stars can be no more than 1 Gyr old, which means that star formation continued to at least z ~ 1.2. Furthermore, a comparison of these distant galaxies with a local SDSS sample, using stellar populations synthesis models, shows that the drop in the equivalent width of Hdelta from z ~ 0.9 to 0.1 is less than predicted by passively evolving models. This admits of two interpretations: either each individual galaxy experiences continuing low-level star formation, or the red-sequence galaxy population from z ~ 0.9 to 0.1 is continually being added to by new galaxies with younger stars.Comment: A few typos were corrected and numbers in Table 1 were revise

Crystalline Silicate Emission in the Protostellar Binary Serpens--SVS20

We present spatially resolved mid-infrared spectroscopy of the class I/flat-spectrum protostellar binary system SVS20 in the Serpens cloud core. The spectra were obtained with the mid-infrared instrument T-ReCS on Gemini-South. SVS20-South, the more luminous of the two sources, exhibits a mid-infrared emission spectrum peaking near 11.3 \micron, while SVS20-North exhibits a shallow amorphous silicate absorption spectrum with a peak optical depth of $\tau \sim 0.3$. After removal of the the line-of-sight extinction by the molecular common envelope, the ``protostar-only'' spectra are found to be dominated by strong amorphous olivine emission peaking near 10 \micron. We also find evidence for emission from crystalline forsterite and enstatite associated with both SVS20-S and SVS20-N. The presence of crystalline silicate in such a young binary system indicates that the grain processing found in more evolved HAeBe and T Tauri pre-main sequence stars likely begins at a relatively young evolutionary stage, while mass accretion is still ongoing.Comment: Accepted for publication by The Astrophysical Journa