Senior Recital: Christopher Malloy, saxophone

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Malloy studies saxophone with Sam Skelton.https://digitalcommons.kennesaw.edu/musicprograms/1523/thumbnail.jp

Living on the edge: a comparison of disturbance-caused edge effects between coniferous and deciduous forest communities.

The study of varying responses to stress between different natural communities is a topic with important implications for applied ecology. In this paper, we compare the effects of similar, road-caused disturbances in deciduous and coniferous communities with respect to the extent of edge characteristics. We predict greater overall edge width in the coniferous forests than in the deciduous sites. We believe this is due at least in part to differences in the characteristic tree form and their effects in shading the borders of the disturbance differentially in the two communities. We find that the widths of edge effects with respect to almost every abiotic and biotic factor measured show virtually no difference between the two forest types. This leads us to conclude that the source of the disturbance, an unimproved dirt road, does not cause measurably different patterns in the fragmentation of community structure between deciduous and coniferous forests. We believe that the variability we observed is revealing, and that it can and should lead to further investigation into the nature of responses to stress across different systems.http://deepblue.lib.umich.edu/bitstream/2027.42/54414/1/2851.pdfDescription of 2851.pdf : Access restricted to on-site users at the U-M Biological Station

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.

BACKGROUND & AIMS: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. METHODS: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). RESULTS: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10(-4), with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10(-6); odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10(-8)), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10(-9); OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). CONCLUSIONS: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.The article is available via Open Access. Click on the 'Additional link' above to access the full-text.Published version, accepted versio