3,360 research outputs found
Probability distributions of smeared quantum stress tensors
We obtain in closed form the probability distribution for individual
measurements of the stress-energy tensor of two-dimensional conformal field
theory in the vacuum state, smeared in time against a Gaussian test function.
The result is a shifted Gamma distribution with the shift given by the
previously known optimal quantum inequality bound. For small values of the
central charge it is overwhelmingly likely that individual measurements of the
sampled energy density in the vacuum give negative results. For the case of a
single massless scalar field, the probability of finding a negative value is
84%. We also report on computations for four-dimensional massless scalar fields
showing that the probability distribution of the smeared square field is also a
shifted Gamma distribution, but that the distribution of the energy density is
not.Comment: 9 pages, 1 figure. Minor edits implemente
Reclaiming the Public Forum: Courts Must Stand Firm Against Governmental Efforts to Displace Dissidence
Recognizing that the right to free speech for dissidents is increasingly at risk in the United States, this submission catalogs manifold methods the government has employed to constrain free speech and urges that courts not only serve as a bulwark against further erosion of public expression of dissent but endeavor to restore access to the public forum that recently has been lost. The submission surveys the background of the right to free expression and provides details and examples of the government’s increasing tendency to suppress dissident speech by deploying heavily armed police in demonstrations, committing violent acts against peaceful protesters, engaging in mass arrests, exaggerating the crimes charged against detained demonstrators, and holding those demonstrators for unreasonably long periods of time in ignominious conditions. Further, the paper briefly examines how such government actions violate constitutional protections of speech by deterring participation in public debate. Beyond such street tactics, government in recent years has begun placing public fora off limits by forcing dissenters into protest pens, determining based on viewpoint where they may engage in political expression, or limiting the landscape of free speech via privatization schemes. Thus, the paper analyzes the First Amendment implications of such developments and concludes that courts must defend the right to free expression by limiting or disallowing these governmental schemes that have the effect of limiting access to the public forum
Multi-scale Renormalisation Group Improvement of the Effective Potential
Using the renormalisation group and a conjecture concerning the perturbation
series for the effective potential, the leading logarithms in the effective
potential are exactly summed for scalar and Yukawa theories.Comment: 19 pages, DIAS STP 94-09. Expanded to check large N limit, typo's
corrected, to appear in Phys Rev
Quantum inequalities and `quantum interest' as eigenvalue problems
Quantum inequalities (QI's) provide lower bounds on the averaged energy
density of a quantum field. We show how the QI's for massless scalar fields in
even dimensional Minkowski space may be reformulated in terms of the positivity
of a certain self-adjoint operator - a generalised Schroedinger operator with
the energy density as the potential - and hence as an eigenvalue problem. We
use this idea to verify that the energy density produced by a moving mirror in
two dimensions is compatible with the QI's for a large class of mirror
trajectories. In addition, we apply this viewpoint to the `quantum interest
conjecture' of Ford and Roman, which asserts that the positive part of an
energy density always overcompensates for any negative components. For various
simple models in two and four dimensions we obtain the best possible bounds on
the `quantum interest rate' and on the maximum delay between a negative pulse
and a compensating positive pulse. Perhaps surprisingly, we find that - in four
dimensions - it is impossible for a positive delta-function pulse of any
magnitude to compensate for a negative delta-function pulse, no matter how
close together they occur.Comment: 18 pages, RevTeX. One new result added; typos fixed. To appear in
Phys. Rev.
On wormholes with arbitrarily small quantities of exotic matter
Recently several models of traversable wormholes have been proposed which
require only arbitrarily small amounts of negative energy to hold them open
against self-collapse. If the exotic matter is assumed to be provided by
quantum fields, then quantum inequalities can be used to place constraints on
the negative energy densities required. In this paper, we introduce an
alternative method for obtaining constraints on wormhole geometries, using a
recently derived quantum inequality bound on the null-contracted stress-energy
averaged over a timelike worldline. The bound allows us to perform a simplified
analysis of general wormhole models, not just those with small quantities of
exotic matter. We then use it to study, in particular, the models of Visser,
Kar, and Dadhich (VKD) and the models of Kuhfittig. The VKD models are
constrained to be either submicroscopic or to have a large discrepancy between
throat size and curvature radius. A recent model of Kuhfittig is shown to be
non-traversable. This is due to the fact that the throat of his wormhole flares
outward so slowly that light rays and particles, starting from outside the
throat, require an infinite lapse of affine parameter to reach the throat.Comment: 30 pages, 2 figure
New insights into the evolutionary history of plant sorbitol dehydrogenase
BACKGROUND:
Sorbitol dehydrogenase (SDH, EC 1.1.1.14) is the key enzyme involved in sorbitol metabolism in higher plants. SDH genes in some Rosaceae species could be divided into two groups. L-idonate-5-dehydrogenase (LIDH, EC 1.1.1.264) is involved in tartaric acid (TA) synthesis in Vitis vinifera and is highly homologous to plant SDHs. Despite efforts to understand the biological functions of plant SDH, the evolutionary history of plant SDH genes and their phylogenetic relationship with the V. vinifera LIDH gene have not been characterized
RESULTS:
A total of 92 SDH genes were identified from 42 angiosperm species. SDH genes have been highly duplicated within the Rosaceae family while monocot, Brassicaceae and most Asterid species exhibit singleton SDH genes. Core Eudicot SDHs have diverged into two phylogenetic lineages, now classified as SDH Class I and SDH Class II. V. vinifera LIDH was identified as a Class II SDH. Tandem duplication played a dominant role in the expansion of plant SDH family and Class II SDH genes were positioned in tandem with Class I SDH genes in several plant genomes. Protein modelling analyses of V. vinifera SDHs revealed 19 putative active site residues, three of which exhibited amino acid substitutions between Class I and Class II SDHs and were influenced by positive natural selection in the SDH Class II lineage. Gene expression analyses also demonstrated a clear transcriptional divergence between Class I and Class II SDH genes in V. vinifera and Citrus sinensis (orange)
CONCLUSIONS:
Phylogenetic, natural selection and synteny analyses provided strong support for the emergence of SDH Class II by positive natural selection after tandem duplication in the common ancestor of core Eudicot plants. The substitutions of three putative active site residues might be responsible for the unique enzyme activity of V. vinifera LIDH, which belongs to SDH Class II and represents a novel function of SDH in V. vinifera that may be true also of other Class II SDHs. Gene expression analyses also supported the divergence of SDH Class II at the expression level. This study will facilitate future research into understanding the biological functions of plant SDH
Probability distributions for quantum stress tensors in four dimensions
We treat the probability distributions for quadratic quantum fields, averaged
with a Lorentzian test function, in four-dimensional Minkowski vacuum. These
distributions share some properties with previous results in two-dimensional
spacetime. Specifically, there is a lower bound at a finite negative value, but
no upper bound. Thus arbitrarily large positive energy density fluctuations are
possible. We are not able to give closed form expressions for the probability
distribution, but rather use calculations of a finite number of moments to
estimate the lower bounds, the asymptotic forms for large positive argument,
and possible fits to the intermediate region. The first 65 moments are used for
these purposes. All of our results are subject to the caveat that these
distributions are not uniquely determined by the moments. However, we also give
bounds on the cumulative distribution function that are valid for any
distribution fitting these moments.We apply the asymptotic form of the
electromagnetic energy density distribution to estimate the nucleation rates of
black holes and of Boltzmann brains.Comment: 26 pages, 2 figure
Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes
Diets rich in fruits and vegetables (FV), which contain (poly)phenols, protect against age-related inflammation and chronic diseases. T-lymphocytes contribute to systemic cytokine production and are modulated by FV intake. Little is known about the relative potency of different (poly)phenols in modulating cytokine release by lymphocytes. We compared thirty-one (poly)phenols and six (poly)phenol mixtures for effects on pro-inflammatory cytokine release by Jurkat T-lymphocytes. Test compounds were incubated with Jurkat cells for 48 h at 1 and 30 µm, with or without phorbol ester treatment at 24 h to induce cytokine release. Three test compounds that reduced cytokine release were further incubated with primary lymphocytes at 0·2 and 1 µm for 24 h, with lipopolysaccharide added at 5 h. Cytokine release was measured, and generation of H2O2 by test compounds was determined to assess any potential correlations with cytokine release. A number of (poly)phenols significantly altered cytokine release from Jurkat cells (P<0·05), but H2O2 generation did not correlate with cytokine release. Resveratrol, isorhamnetin, curcumin, vanillic acid and specific (poly)phenol mixtures reduced pro-inflammatory cytokine release from T-lymphocytes, and there was evidence for interaction between (poly)phenols to further modulate cytokine release. The release of interferon-γ induced protein 10 by primary lymphocytes was significantly reduced following treatment with 1 µm isorhamnetin (P<0·05). These results suggest that (poly)phenols derived from onions, turmeric, red grapes, green tea and açai berries may help reduce the release of pro-inflammatory mediators in people at risk of chronic inflammation
A Search for Exozodiacal Clouds with Kepler
Planets embedded within dust disks may drive the formation of large scale
clumpy dust structures by trapping dust into resonant orbits. Detection and
subsequent modeling of the dust structures would help constrain the mass and
orbit of the planet and the disk architecture, give clues to the history of the
planetary system, and provide a statistical estimate of disk asymmetry for
future exoEarth-imaging missions. Here we present the first search for these
resonant structures in the inner regions of planetary systems by analyzing the
light curves of hot Jupiter planetary candidates identified by the Kepler
mission. We detect only one candidate disk structure associated with KOI 838.01
at the 3-sigma confidence level, but subsequent radial velocity measurements
reveal that KOI 838.01 is a grazing eclipsing binary and the candidate disk
structure is a false positive. Using our null result, we place an upper limit
on the frequency of dense exozodi structures created by hot Jupiters. We find
that at the 90% confidence level, less than 21% of Kepler hot Jupiters create
resonant dust clumps that lead and trail the planet by ~90 degrees with optical
depths >~5*10^-6, which corresponds to the resonant structure expected for a
lone hot Jupiter perturbing a dynamically cold dust disk 50 times as dense as
the zodiacal cloud.Comment: 22 pages, 6 figures, Accepted for publication in Ap
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