Magnetic inflation and stellar mass. V. Intensification and saturation of M-dwarf absorption lines with Rossby number

In young Sun-like stars and field M-dwarf stars, chromospheric and coronal magnetic activity indicators such as Hα, X-ray, and radio emission are known to saturate with low Rossby number (Ro lesssim 0.1), defined as the ratio of rotation period to convective turnover time. The mechanism for the saturation is unclear. In this paper, we use photospheric Ti i and Ca i absorption lines in the Y band to investigate magnetic field strength in M dwarfs for Rossby numbers between 0.01 and 1.0. The equivalent widths of the lines are magnetically enhanced by photospheric spots, a global field, or a combination of the two. The equivalent widths behave qualitatively similar to the chromospheric and coronal indicators: we see increasing equivalent widths (increasing absorption) with decreasing Ro and saturation of the equivalent widths for Ro lesssim 0.1. The majority of M dwarfs in this study are fully convective. The results add to mounting evidence that the magnetic saturation mechanism occurs at or beneath the stellar photosphere.Published versio

Hydrothermal activity lowers trophic diversity in Antarctic sedimented hydrothermal vents

Sedimented hydrothermal vents are those in which hydrothermal fluid vents through sediment and are among the least studied deep-sea ecosystems. We present a combination of microbial and biochemical data to assess trophodynamics between and within hydrothermally active and off-vent areas of the Bransfield Strait (1050–1647 m depth). Microbial composition, biomass and fatty acid signatures varied widely between and within vent and non-vent sites and provided evidence of diverse metabolic activity. Several species showed diverse feeding strategies and occupied different trophic positions in vent and non-vent areas and stable isotope values of consumers were generally not consistent with feeding structure morphology. Niche area and the diversity of microbial fatty acids reflected trends in species diversity and was lowest at the most hydrothermally active site. Faunal utilisation of chemosynthetic activity was relatively limited but was detected at both vent and non-vent sites as evidenced by carbon and sulphur isotopic signatures, suggesting that the hydrothermal activity can affect trophodynamics over a much wider area than previously thought

El Mañana: Año III Número 501 - (26/08/30)

Synchronous, time-resolved DRIFTS/MS/XAS cycling studies of the vapor phase selective aerobic oxidation of crotyl alcohol over nanoparticulate palladium reveal surface oxide as the desired catalytically active phase, with dynamic, reaction-induced palladium redox processes controlling selective versus combustion pathways

Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity

Approximately 20  % of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm -forming ability. Recently, there has been increasing evidence of C. albicans biofilm heterogeneity and the negative impact it can have clinically; however, this phenomenon has yet to be studied in relation to denture isolates. The aims of this study were to evaluate C. albicans biofilm formation of clinical denture isolates in a denture environment and to assess antimicrobial activity of common denture cleansers against these tenacious communities. C. albicans isolated from dentures of healthy and diseased individuals was quantified using real-time PCR and biofilm biomass assessed using crystal violet. Biofilm development on the denture substratum poly(methyl methacrylate), Molloplast B and Ufi-gel was determined. Biofilm formation was assessed using metabolic and biomass stains, following treatment with denture hygiene products. Although C. albicans was detected in greater quantities in diseased individuals, it was not associated with increased biofilm biomass. Denture substrata were shown to influence biofilm biomass, with poly(methyl methacrylate) providing the most suitable environment for C. albicans to reside. Of all denture hygiene products tested, Milton had the most effective antimicrobial activity, reducing biofilm biomass and viability the greatest. Overall, our results highlight the complex nature of denture- related disease, and disease development cannot always be attributed to a sole cause. It is the distinct combination of various factors that ultimately determines the pathogenic outcome

Acción : diario de Teruel y su provincia: Año II Número 116 - (06/04/33)

The selective aerobic oxidation of crotyl alcohol to crotonaldehyde was investigated by time-resolved synchronous DRIFTS/MS/XAS over silica and alumina supported Pd nanoparticles. Alcohol and oxygen reactant feeds were cycled through the catalyst bed while dynamic measurements of the palladium oxidation state, molecular adsorbates and evolved product distribution were made simultaneously on a sub-second timescale. Highly dispersed palladium nanoparticles remained in a partially oxidised state <100 degrees C, independent of the redox environment, and were selective for crotonaldehyde formation. Higher temperatures facilitated rapid catalyst reduction on exposure to crotyl alcohol, with palladium metal driving crotonaldehyde decarbonylation to propene and CO, while slower (surface diffusion-limited) reoxidation on exposure to oxygen re-opened selective oxidation pathways. Surface palladium oxide is identified as the desired active species

Antibody profiling of patients with prostate cancer reveals differences in antibody signatures among disease stages

BACKGROUND: Previous studies of prostate cancer autoantibodies have largely focused on diagnostic applications. So far, there have been no reports attempting to more comprehensively profile the landscape of prostate cancer-associated antibodies. Specifically, it is unknown whether the quantity of antibodies or the types of proteins recognized change with disease progression. METHODS: A peptide microarray spanning the amino acid sequences of the gene products of 1611 prostate cancer-associated genes was synthesized. Serum samples from healthy male volunteers (n=15) and patients with prostate cancer (n=85) were used to probe the array. These samples included patients with various clinical stages of disease: newly diagnosed localized prostate cancer (n=15), castration-sensitive non-metastatic prostate cancer (nmCSPC, n=40), castration-resistant non-metastatic prostate cancer (n=15) and castration-resistant metastatic disease (n=15). The patients with nmCSPC received treatment with either standard androgen deprivation therapy (ADT) or an antitumor DNA vaccine encoding prostatic acid phosphatase. Serial sera samples from these individuals were also used to probe the array, to secondarily determine whether this approach could be used to detect treatment-related changes. RESULTS: We demonstrated that this peptide array yielded highly reproducible measurements of serum IgG levels. We found that the overall number of antibody responses did not increase with disease burden. However, the composition of recognized proteins shifted with clinical stage of disease. Our analysis revealed that the largest difference was between patients with castration-sensitive and castration-resistant disease. Patients with castration-resistant disease recognized more proteins associated with nucleic acid binding and gene regulation compared with men in other groups. Our longitudinal data showed that treatments can elicit antibodies detectable by this array, and notably vaccine-treated patients developed increased responses to more proteins over the course of treatment than did ADT-treated patients. CONCLUSIONS: This study represents the largest survey of prostate cancer-associated antibodies to date. We have been able to characterize the classes of proteins recognized by patients and determine how they change with disease burden. Our findings further demonstrate the potential of this platform for measuring antigen spread and studying responses to immunomodulatory therapies

Regional and temporal variability in Puget Sound zooplankton: bottom-up links to juvenile salmon

We use data from the Puget Sound Zooplankton Monitoring Program to explore patterns of spatial and interannual variability in zooplankton communities in response to environmental change during 2014-2017. This program is a collaborative effort involving 10 tribal, county, state, federal, academic, and nonprofit entities initiated via the Salish Sea Marine Survival Project with the goal of understanding the key role of zooplankton in food webs and ecosystems. Large interannual differences in the environment over this period strong effects on zooplankton community structure and abundance. 2014 began as a fairly normal year in Puget Sound until the Pacific Warm Anomaly event nicknamed “The Blob” began to affect the region during late summer and fall. Unprecedented warm anomalies occurred in summer 2015, persisting through 2016. Off the coast of Washington and Oregon, clear effects on zooplankton community structure were observed, with rare oceanic species occurring in coastal samples concurrent with decreased overall biomass. In sharp contrast, few rare species were collected in Puget Sound, and zooplankton increased in 2015 and 2016 relative to 2014, including increases in nearly all taxa that are important juvenile salmon prey. A few taxa, most notably the dinoflagellate Noctiluca and numerous species of small jellyfish, decreased during the warm years, and shifts in the seasonal phenology of some taxa were observed. These and other findings from the Puget Sound Zooplankton Monitoring Program will be presented in the context of the implications of environmental change for juvenile salmon growth and survival

One Health and Global Health View of Antimicrobial Susceptibility through the “Eye” of Aeromonas: Systematic Review and Meta-Analysis

Antimicrobial resistance (AMR) is one of the most pressing public health concerns; therefore, it is imperative to advance our understanding of the factors influencing AMR from Global and One Health perspectives. To address this, Aeromonas populations were identified using 16S rRNA gene libraries among human, agriculture, aquaculture, drinking water, surface water, and wastewater samples, supporting its use as indicator bacteria to study AMR. A systematic review and meta-analysis was then performed from Global and One Health perspectives, including data from 221 articles describing 15 891 isolates from 57 countries. The interconnectedness of different environments was evident as minimal differences were identified between sectors among 21 different antimicrobials. However, resistance to critically important antibiotics (aztreonam and cefepime) was significantly higher among wastewater populations compared with clinical isolates. Additionally, isolates from untreated wastewater typically exhibited increased AMR compared with those from treated wastewater. Furthermore, aquaculture was associated with increased AMR to ciprofloxacin and tetracycline compared with wild-caught seafood. Using the World Health Organization AWaRe classifications, countries with lower consumption of “Access” compared to “Watch” drugs from 2000 to 2015 demonstrated higher AMR levels. The current analysis revealed negative correlations between AMR and anthropogenic factors, such as environmental performance indices and socioeconomic standing. Environmental health and sanitation were two of the environmental factors most strongly correlated with AMR. The current analysis highlights the negative impacts of “Watch” drug overconsumption, anthropogenic activity, absence of wastewater infrastructure, and aquaculture on AMR, thus stressing the need for proper infrastructure and global regulations to combat this growing problem