Language education and multilingualism at school: a critique of terminology

Der Beitrag möchte dazu aufrufen, Konzepte wie Mehrsprachigkeit, Deutsch als Zweitsprache (DaZ) und Bildungssprache zu hinterfragen und ihren Weg von der wissenschaftlichen Kategorie zu einem eher alltagssprachlichen Begriff zu problematisieren. Die Autor*innen argumentieren, dass es einen differenzierten Blick auf die mehrsprachigen Realitäten von Schüler*innen und damit eine differenzierte Wahrnehmung ihrer Potenziale und Bedarfe braucht. (DIPF/Orig.)The contribution aims at a critical analysis of concepts such as “multilingualism”, “German as a second language” and “academic language”. The authors problematize the way in which an understanding of these concepts has moved from an academic category to a more everyday usage. They furthermore argue that a more differentiated view of the multilingual realities of pupils and thus a differentiated perception of their potentials and needs are required. (DIPF/Orig.

A rare complication of ureteral stenting: Case report of a uretero-arterial fistula and revision of the literature

Introduction: Uretero-arterial fistulas are a rare condition. The most frequent clinical sign is hematuria. Since these bleedings occur intermittently, the diagnosis is very difficult. If not discovered, uretero-arterial fistulas involve a very high rate of mortality or even results in loss of kidney function. Case report: The clinical case we describe is an unusual one. After a radical hysterectomy and a subsequent radiotherapy, a hydronephrosis caused by ureteral fibrosis occurred on both sides. Therefore, the patient received bilateral ureteral stents. During a change of the ureteral stents 18 months later, a massive bleeding appeared in the right ureter. Initially, a clear evidence of a fistula was not possible - neither through CT scan nor through selective angiography. There were some indicators of a uretero-arterial fistula, so an endoluminal vessel stent was placed. Subsequently the fistula probably led to an erosion of the vessel stent. Discussion: A fistula between the ureter and the iliac artery (UAF) is a rare complication. The increase in known cases during the last years is linked to the possibility of ureteral stenting since 1978. Until now only 140 cases have been described in literature. The mortality rate through UAF has decreased from 69% in 1980 to 7-23% today. Its development can be traced through the pulsation of the artery and the pressure on the ureter. The most important clinical symptom is bleeding. Diagnosis is generally difficult and represents the real problem. The sensitivity of the standard angiography examination is 23- 41%; it can be improved to 63% using the “provocative” method, which means mobilizing the ureteral stent during examination. The therapy in course of the angiography consists of a simultaneous endovascular stent and/or a co-embolisation. Conclusion: Arterial or uretero-arterial fistulas (UAF) are a rare condition; the diagnosis is very difficult and most of the time the treatment requires a multidisciplinary team

Anterior implant restorations with a convex emergence profile increase the frequency of recession: 12-month results of a randomized controlled clinical trial

AIM To test whether the emergence profile (CONVEX or CONCAVE) of implant-supported crowns influences the mucosal margin stability up to 12 months after insertion of the final restoration. MATERIALS AND METHODS Forty-seven patients with a single implant in the anterior region were randomly allocated to one of three groups: (1) CONVEX (n = 15), implant provisional and an implant-supported crown both with a convex profile; (2) CONCAVE (n = 16), implant provisional and an implant-supported crown both with a concave profile; (3) CONTROL (n = 16), no provisional (healing abutment only) and an implant-supported crown. All patients were recalled at baseline, 6, and 12 months. The stability of mucosal margin along with clinical, aesthetic, and profilometric outcomes as well as time and costs were evaluated. To predict the presence of recession, multivariable logistic regressions were performed and linear models using generalized estimation equations were conducted for the different outcomes. RESULTS Forty-four patients were available at 12 months post-loading. The frequency of mucosal recession amounted to 64.3% in group CONVEX, 14.3% in group CONCAVE, and 31.4% in group CONTROL. Regression models revealed that a CONVEX profile was significantly associated with the presence of recessions (odds ratio: 12.6, 95% confidence interval: 1.82-88.48, p = .01) compared with the CONCAVE profile. Pink aesthetic scores amounted to 5.9 in group CONVEX, 6.2 in group CONCAVE, and 5.4 in group CONTROL, with no significant differences between the groups (p = .735). Groups CONVEX and CONCAVE increased the appointments and costs compared with the CONTROL group. CONCLUSIONS The use of implant-supported provisionals with a CONCAVE emergence profile results in a greater stability of the mucosal margin compared with a CONVEX profile up to 12 months of loading. This is accompanied, however, by increased time and costs compared with the absence of a provisional and may not necessarily enhance the aesthetic outcomes. TRIAL REGISTRATION German Clinical Trials Register; DRKS00009420

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity

Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two signaling branches, one cGMP- and the other Ca(2+)-dependent, of which many signaling components have yet to be identified. The STATc stress signalling pathway feeds back on itself by upregulating the expression of STATc and STATc-regulated genes. Based on microarray studies we chose two tyrosine-kinase like proteins, Pyk3 and Phg2, as possible modulators of STATc phosphorylation and generated single and double knock-out mutants to them. Transcriptional regulation of STATc and STATc dependent genes was disturbed in pyk3(-), phg2(-), and pyk3(-)/phg2(-) cells. The absence of Pyk3 and/or Phg2 resulted in diminished or completely abolished increased transcription of STATc dependent genes in response to sorbitol, 8-Br-cGMP and the Ca(2+) liberator BHQ. Also, phospho-STATc levels were significantly reduced in pyk3(-) and phg2(-) cells and even further decreased in pyk3(-)/phg2(-) cells. The reduced phosphorylation was mirrored by a significant delay in nuclear translocation of GFP-STATc. The protein tyrosine phosphatase 3 (PTP3), which dephosphorylates and inhibits STATc, is inhibited by stress-induced phosphorylation on S448 and S747. Use of phosphoserine specific antibodies showed that Phg2 but not Pyk3 is involved in the phosphorylation of PTP3 on S747. In pull-down assays Phg2 and PTP3 interact directly, suggesting that Phg2 phosphorylates PTP3 on S747 in vivo. Phosphorylation of S448 was unchanged in phg2(-) cells. We show that Phg2 and an, as yet unknown, S448 protein kinase are responsible for PTP3 phosphorylation and hence its inhibition, and that Pyk3 is involved in the regulation of STATc by either directly or indirectly activating it. Our results add further complexities to the regulation of STATc, which presumably ensure its optimal activation in response to different environmental cues

Veneered zirconia abutments cemented on non‐original titanium bases: 1‐year results of a prospective case series

Objectives To assess clinical, technical, and esthetic outcomes of veneered zirconia reconstructions cemented on non‐original titanium bases over 1 year. Materials and methods Twenty‐four healthy patients presented with one missing tooth in the anterior maxilla or mandible and received a two‐piece dental implant. The implants were restored with a screw‐retained crown using a directly veneered zirconia reconstruction, which was extraorally cemented on a titanium base. After crown insertion, patients were scheduled for a baseline examination and re‐examined at 6 months and at 1 year of loading. Measurements included biological, technical, and esthetic parameters. Data were analyzed with nonparametric tests. Results Mean marginal bone levels measured 0.54 ± 0.39 mm (median: 0.47, range: 0.07–1.75 mm) at baseline and 0.54 ± 0.45 mm (median: 0.44, range: 0.06–1.52 mm) at 1 year. Mean probing depth (PD) (3.0 ± 0.6 mm at baseline to 3.5 ± 0.7 mm at 1 year [p = 0.002]), bleeding on probing (BOP) (27.1% ± 20.7% at baseline to 43.9% ± 28.0% at 1 year [p = 0.041]), plaque index (PI) (11.1% ± 21.2% at baseline to 18.2% ± 21.8% at 1 year [p = 0.381]) increased, whereas the width of the keratinized mucosa decreased from baseline to 1 year (3.1 ± 1.3 mm at baseline to 3.0 ± 1.2 mm at 1 year [p = 0.398]). Four implants (16.7%) were diagnosed with peri‐implantitis (BOP positive, bone loss >1 mm) during the 1‐year observation period. One implant was lost at 3 ½ months, resulting in a 95.8% survival rate. Four technical complications occurred and led to 83.3% complication‐free reconstructions. Conclusion A significant increase in PD and BOP values was observed using directly veneered zirconia reconstructions cemented on non‐original titanium base

Veneered zirconia abutments cemented on non-original titanium bases: 1-year results of a prospective case series

To assess clinical, technical, and esthetic outcomes of veneered zirconia reconstructions cemented on non-original titanium bases over 1 year

No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract

Mutational activation of the MAP kinase pathway is frequently found in various cancers. Recently, activating mutations in the B-RAF gene, an important activator of this pathway, have been described in several tumor types including melanoma, colorectal and papillary thyroid cancer. The most frequent mutation in exon 15 (V599E), as well as several other mutations within exons 11 and 15 result in constitutive activation of the oncoprotein. In addition, a significant association between mismatch-repair (MMR) deficiency and the V599E mutation in colorectal tumors has been found. The aim of our study was to investigate B-RAF mutations in 121 urothelial carcinomas of the urinary bladder (ranging from pTaG1 to pT4aG3) and 27 tumors from the upper urinary tract (UUT), including 16 tumors of the renal pelvis and 11 tumors of the ureter). Twelve of 27 UUT tumors were MMR-deficient and showed microsatellite instability. The V599E mutation was screened for by allele-specific PCR (PASA) and exons 11 and 15 of B-RAF including intron-exon-boundaries were sequenced. Overall, 116/121 bladder tumors and 23/27 tumors of the UUT were successfully investigated by PASA. None of the tumors showed the V599E mutation. Sequence analysis of exons 11 and 15 was successful in 46 urothelial tumors (bladder, n=31; UUT, n=15). No mutations within the coding region of exons 11 and 15 and the intron-exon junctions were found. The most frequent alterations in the B-RAF gene do not seem to be involved in urothelial carcinogenesis, and there is no correlation between MMR-deficiency and B-RAF mutations in urothelial tumors

Randomized controlled clinical trial comparing one-piece and two-piece dental implants supporting fixed and removable dental prostheses: 4- to 6-year observations

OBJECTIVES To test whether or not a one- (S1) and a two-piece (S2) dental implant systems render the same biological, technical, and esthetic outcomes regarding implants and implant-supported reconstructions over an observation period of 4 to 6 years. MATERIALS AND METHODS Sixty patients were randomly assigned to receive S1 or S2 implants. The implants were restored with either fixed or removable prostheses. The insertion of the final reconstruction was chosen as baseline. One-year and 4- to 6-year (FU-5) measurements included biological (e.g. marginal bone level, probing pocket depth, peri-implant mucositis, and peri-implantitis), technical (e.g. fracture or loosening of prosthetic screws, fracture or loosening of abutments, fracture of framework, and/or veneering ceramic (minor, major), loss of retention for cemented restorations), and esthetic parameters (visibility of the crown margin, shimmering of the implant through the mucosa, the level of the facial margo mucosae compared to the contralateral tooth or implant site and the modified papilla index) for implants and reconstructions. Survival and success rates of implants and reconstructions were calculated. Because of the asymmetric data distributions, nonparametric statistical methods were applied. RESULTS The implant-based analysis revealed a cumulative implant survival rate of 97.9% (S1: 96.6%; S2: 98.9%) at FU-5. The median marginal bone level for group S1 changed from 0.51 mm at baseline to 0.49 mm at FU-5 and for group S2 from 1.02 mm to 1.35 mm (P 0.05). CONCLUSIONS Both implant systems reveal high survival rates on the implant and prosthetic level. Apart from marginal bone-level changes, biological and technical outcomes did not reveal significant differences between the two implant systems