The World Is Old and New Again: Cultural Trauma and September 11, 2001

This dissertation explores the emergent cultural aftereffects of September 11, 2001. I consider how popular US narratives from the decade following that day's events evidence an ongoing, pervasive struggle with certain of the hijackings' especially troubling features, manifesting September 11 as a cultural trauma. I distinguish cultural trauma as an intersubjective phenomenon from psychological trauma and its individualized emphasis. I also distinguish my approach from the dominant ways historical, cultural and literary studies have typically conceptualized trauma as a primarily Freudian-theorized, pathological reaction to extreme happenings. Rather, drawing on Janoff-Bulman's shattered assumptions model of psychological trauma, I define cultural trauma as a radical disruption of basic, common, taken-for-granted, culturally-generated and -structured beliefs about what constitutes a community's ordinary life. I focus on how the hijackings' shocking and well-publicized developments shattered assumptions fundamental to mainstream American understandings of daily life. To trace these shattered assumptions, I review ten popular culture texts: three popular press oral history collections - the 2002 September 11: An Oral History, the 2002 Never Forget: An Oral History of September 11, and the 2007 Tower Stories: An Oral History of 9/11 - as well as the 2002 Frontline documentary "Faith and Doubt at Ground Zero"; the 2003 Tom Junod Esquire article "The Falling Man"; the mid-to-late-2000s television series Lost, Battlestar Galactica, and FlashForward; the 2008 Christopher Nolan film The Dark Knight; and the 2007 Don DeLillo novel Falling Man. By assessing and comparing these texts' primary thematic concerns, I outline how each narrative, situated in varying media and genres, engages vulnerability in the forms of existential insecurity and the troubling of meaningful and ethical choice, exposing fragmented foundational beliefs in the wake of September 11. However, instead of reconstructing these fragmented pieces into an unequivocal new whole, these texts ambivalently instantiate that day's unresolved cultural fallout, serving to document the still evolving structures of feeling constituting this cultural trauma. Accordingly, this study evidences how popular culture serves as a site for recognizing and negotiating September 11 as a cultural trauma while suggesting how cultural trauma might be recognized and negotiated at other times of stark cultural change

Cognitively-Engineered Multisensor Data Fusion Systems for Military Applications

The fusion of imagery from multiple sensors is a field of research that has been gaining prominence in the scientific community in recent years. The technical aspects of combining multisensory information have been and are currently being studied extensively. However, the cognitive aspects of multisensor data fusion have not received so much attention. Prior research in the field of cognitive engineering has shown that the cognitive aspects of any human-machine system should be taken into consideration in order to achieve systems that are both safe and useful. The goal of this research was to model how humans interpret multisensory data, and to evaluate the value of a cognitively-engineered multisensory data fusion system as an effective, time-saving means of presenting information in high- stress situations. Specifically, this research used principles from cognitive engineering to design, implement, and evaluate a multisensor data fusion system for pilots in high-stress situations. Two preliminary studies were performed, and concurrent protocol analysis was conducted to determine how humans interpret and mentally fuse information from multiple sensors in both low- and high-stress environments. This information was used to develop a model for human processing of information from multiple data sources. This model was then implemented in the development of algorithms for fusing imagery from several disparate sensors (visible and infrared). The model and the system as a whole were empirically evaluated in an experiment with fighter pilots in a simulated combat environment. The results show that the model is an accurate depiction of how humans interpret information from multiple disparate sensors, and that the algorithms show promise for assisting fighter pilots in quicker and more accurate target identification

Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro

The growth rate of numerous cancer cell lines is regulated in part by actions of neuropeptides of the vasoactive intestinal peptide (VIP) family, which also includes pituitary adenylate cyclase-activating peptide (PACAP), glucagon, and peptide histidine/isoleucine (PHI). The aim of this work was to investigate the effect of these peptides on the growth of the rat glioblastoma cell line C6 in vitro. We also sought to determine which binding sites were correlated with the effects observed. Proliferation studies performed by means of a CyQuant trade mark assay showed that VIP and PACAP strongly stimulated C6 cell proliferation at most of the concentrations tested, whereas PHI increased cell proliferation only when associated with VIP. Two growth hormone-releasing factor (GRF) derivatives and the VIP antagonist hybrid peptide neurotensin-VIP were able to inhibit VIP-induced cell growth stimulation, even at very low concentrations. Binding experiments carried out on intact cultured C6 cells, using 125I-labeled VIP and PACAP as tracers, revealed that the effects of the peptides on cell growth were correlated with the expression on C6 cells of polyvalent high-affinity VIP-PACAP binding sites and of a second subtype corresponding to very high-affinity VIP-selective binding species. The latter subtype, which interacted poorly with PACAP with a 10,000-fold lower affinity than VIP, might mediate the antagonist effects of neurotensin- VIP and of both GRF derivatives on VIP-induced cell growth stimulation

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats

The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9, 0-1% (w/v) lauroylcarnitine (LC), hypo- or isoosmolality) on the brain uptake of intranasally administered VIP (10(-8)M)/125I-VIP (300,000 cpm/ml) was studied, using an in situ perfusion technique. Brain radioactivity distribution was assessed by quantitative autoradiographic analysis. Results were compared to intravenously administered VIP. With a hypotonic formulation at pH 4 containing 0.1% LC and 1% bovine serum albumin, VIP stability was satisfactory and loss by adsorption was minimal. Using this formulation, around 0.11% of initial radioactivity was found in the brain after 30 min perfusion and was located in the olfactory bulbs, the midbrain and the cerebellum. HPLC analysis of brain and blood extracts demonstrated the presence of intact VIP in brain and its complete degradation in the blood compartment. By intravenous administration, no intact VIP was found either in brain or in blood. In conclusion, intact VIP could be delivered successfully to the brain using the intranasal route for administration

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles

The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using dimethylsuberimidate (DMSI). For comparison, glucose targeted niosomes were prepared using N-palmitoyl glucosamine. Biological properties were studied using confocal microscopy, flow cytometry, and cytotoxicity assays as well as a mouse xenograft model. Tf vesicles were taken up rapidly with a plateau after 1-2 h and Dox reached the nucleus after 60-90 min. Uptake was not increased with the use of glucose ligands, but higher uptake and increased cytotoxicity were observed for Tf targeted as compared to GCP Dox alone. In the drug-resistant A2780AD cells and in A431 cells, the relative increase in activity was significantly higher for the Tf-GCP vesicles than would have been expected from the uptake studies. All vesicle formulations had a superior in vivo safety profile compared to the free drug. The in vitro advantage of targeted Tf vesicles did not translate into a therapeutic advantage in vivo. All vesicles reduced tumor size on day 2 but were overall less active than the free drug

The origin and evolution of a recent agricultural weed: population genetic diversity of weedy populations of sunflower (Helianthus annuus L.) in Spain and France

The recurrent evolution of crop-related weeds during agricultural history raises serious economic problems and challenging scientific questions. Weedy forms of sunflower, a species native from America, have been reported in European sunflower fields for a few decades. In order to understand their origin, we analysed the genetic diversity of a sample of weedy populations from France and Spain, and of conventional and ornamental varieties. A crop-specific maternally inherited marker was present in all weeds. At 16 microsatellite loci, the weedy populations shared most of their diversity with the conventional varieties. But they showed a large number of additional alleles absent from the cultivated pool. European weedy populations thus most probably originated from the unintentional pollination of maternal lines in seed production fields by wild plants growing nearby, resulting in the introduction of crop-wild hybrids into the farmers’ fields. The wide diversity and the low population structure detected were indicative of a multiplicity of introductions events rather than of field-to-field propagation. Further studies are required to understand the local evolutionary dynamics of a weedy population, and especially the respective roles of crop-to-weed gene flow and selection in the fate of an initial source of crop-wild hybrids

Les nouveaux programmes pour l’école primaire

De nouveaux objectifs, des démarches inédites pour l’élaboration des programmes ont permis d’aboutir à des textes pour l’école primaire qui, depuis 1995, sont progressivement mis en œuvre. Ce descriptif permet d’appréhender la procédure suivie par le ministère de l’Éducation nationale pour mener à bien les opérations prévues, en ce domaine, par le Nouveau contrat pour l’école

Sustainable and healthy diets: trade-offs and synergies : final scientific report

This project aimed at analysing trade-offs and synergies between healthy nutrition and sustainable food systems. First, we identified nutritional patters of the Swiss population based on representative consumption data. The health impacts of these nutritional patterns were then analysed based on a review of the scientific literature on health impacts of food commodities and diets and by calculating the Alternate Healthy Eating Index (AHEI), the Mediterranean Diet Score (MDS) and Disability Adjusted Life Years (DALYs) of the nutritional patterns. Second, we comprehensively analysed health, environmental, social and economic impacts and related trade-offs and synergies for a number of future scenarios of Swiss agricultural production and food consumption. For this, we used a modelling approach, linking three different models: a global mass flow model, a system dynamics model and an environmentally extended input-output model. We modelled ten different scenarios for the Swiss Food Sector in 2050. These scenarios were either developed in a participatory process during a series of interviews and group discussions with different groups of stakeholders or optimised environmental impacts while at the same time complying with different nutritional and agronomic restrictions. Three main scenarios were analysed with all three models in detail. Among these main scenarios was the SwissFoodPyramid2050 Scenario, which assumes a widespread implementation of the nutritional recommendations according to the Swiss Food Pyramid. The FeedNoFood2050 Scenario assumes an improved use of agricultural land by feeding only grass and by-products to livestock, which was not competing with direct human nutrition, i.e. did not require arable land (neither in Switzerland nor abroad). The third scenario was a reference scenario, which assumes no changes in diets until 2050 and which was used to compare the two alternative scenarios. The other scenarios were targeted at specific questions such as minimizing greenhouse gases. Our results illustrate two visions of how healthy diets and sustainable food systems could look like. Both the SwissFoodPyramid2050 and the FeedNoFood2005 scenarios would require similar dietary changes, such as a reduction of meat consumption and an increase of consumption of pulses. However, there are also fundamental differences between the diets in the two alternative scenarios, e.g. regarding the type of meat consumed. These differences can be interpreted as trade-offs which result from agronomic boundary conditions such as the coupled production of milk and meat, the availability of natural resources, such as grassland and co-products of food processing and health aspects of Swiss diets. Of primary importance in this respect was the use of permanent grasslands and the co-production of veal and beef with dairy production due to environmental reasons and reasons for optimally utilizing available resources. This means, if permanent grassland should be maintained as an ecosystem, dairy production would provide the basis for animal proteins. Thus, while in the FeedNoFood2050 Scenario veal and rather low-quality beef from dairy cows is consumed instead of meat from monogastrics, the SwissFoodPyramid2050 Scenario would result in a higher amount of meat from monogastrics. Our results imply that there is a lack of a comprehensive food systems view in the current discussion on healthy and sustainable diets. Stronger coherence between health, food and agricultural policy is needed to account for systemic boundary conditions and thus to allow for minimising trade-offs and maximise synergies. Current agricultural policies fail to address the health perspective. Financial support for meat and sugar producers, which lead to lower prices for those products and ultimately to a higher consumption than without these policies, are two obvious examples. Yet, comprehensive visions such as the SwissFoodPyramid scenario, the FeedNoFood Scenario or optimised scenarios would require an even more complex policy mix of incentives, regulations and information campaigns. This would probably need an adaptation of the current institutional setting and division of competences between the Federal Offices for Agriculture (FOAG) and for the Environment (FOEN), the State Secretariat for Economic Affairs (SECO) and the Federal Food Safety and Veterinary Office (FSVO). A commonly shared vision, including specific goals with respect to how the Swiss food system should look like, is urgently needed. Developing such a vision needs to involve all operators and stakeholders of the food system, as our results imply that more sustainable and healthy diets do not necessarily go along with financial benefits of both producers and consumers. These trade-offs and the knowledge of behavioural economics need to be considered for designing settings which create mutual benefits for operators in the food sector. For instance, neither the majority of consumers, food industry nor agricultural producers can be expected to respond altruistically as an entire sector in the long term. Therefore, policy needs to set financial incentives for internalising environmental and social externalities in order to push and pull the food system towards sustainability. Furthermore, it is crucial to account for agronomic boundary conditions and systemic aspects, such as the role of ruminants in utilizing grasslands and the unavoidable link of milk and meat production