Sierra Leone`s post-conflict reconstruction: a study of the challenges for building long term peace

The main purpose of this research was to understand the civil war in Sierra Leone and its antecedents, and to analyse the package of reconstruction reforms which came along in the post-war era and their relevance for and impact on the local challenges for longer term peace. Continued corruption among the political class, the persistent disenfranchisement of important social groups, and emerging tensions along political party lines suggested that, ten years on from the Lomé Peace Accord, there may have been a malaise in the peacebuilding plan. To investigate the complex issues, and to support the hypothesis that the model for reconstruction was not best suited to local conditions and local priorities, the work first made a deep interrogation of the historic political, cultural and economic factors which led to the violent conflict. This scrutiny of the local experience allowed the conceptualisation of a germane ¿framework for peace` which represented the most pressing priorities of the local community and the central challenges for peace. The framework reflected the main concerns of the local populace and was used as an analytical tool to better understand the relevance of the model for reconstruction vis-à-vis the local context. Through a critical analysis of the post-war reforms and their impact on the social dimensions of recovery, in particular macro-economic reforms and the promotion of democracy, conclusions were drawn about the appropriateness and efficacy of the model of reconstruction experienced in Sierra Leone and how it supported local priorities for peace. The enquiry found that, in general, the model for reconstruction was not best suited to the local context because of its inflexibility to support the local peacebuilding and its many challenges. In some ways the model for reconstruction heightened residual tensions from the conflict because it failed to address key issues for reform such as governance and social justice.Economic and Social Research Counci

Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas

BackgroundLow penetrance genetic variants, primarily single nucleotide polymorphisms, have substantial influence on colorectal cancer (CRC) susceptibility. Most CRCs develop from colorectal adenomas (CRA). Here we report the first comprehensive field synopsis that catalogues all genetic association studies on CRA, with a parallel online database [http://www.chs.med.ed.ac.uk/CRAgene/].MethodsWe performed a systematic review, reviewing 9750 titles, and then extracted data from 130 publications reporting on 181 polymorphisms in 74 genes. We conducted meta-analyses to derive summary effect estimates for 37 polymorphisms in 26 genes. We applied the Venice criteria and Bayesian False Discovery Probability (BFDP) to assess the levels of the credibility of associations.ResultsWe considered the association with the rs6983267 variant at 8q24 as 'highly credible', reaching genome-wide statistical significance in at least one meta-analysis model. We identified 'less credible' associations (higher heterogeneity, lower statistical power, BFDP > 0.02) with a further four variants of four independent genes: MTHFR c.677C>T p.A222V (rs1801133), TP53 c.215C>G p.R72P (rs1042522), NQO1 c.559C>T p.P187S (rs1800566), and NAT1 alleles imputed as fast acetylator genotypes. For the remaining 32 variants of 22 genes for which positive associations with CRA risk have been previously reported, the meta-analyses revealed no credible evidence to support these as true associations.ConclusionsThe limited number of credible associations between low penetrance genetic variants and CRA reflects the lower volume of evidence and associated lack of statistical power to detect associations of the magnitude typically observed for genetic variants and chronic diseases. The CRA gene database provides context for CRA genetic association data and will help inform future research directions

Sierra Leone's post-conflict reconstruction : a study of the challenges for building long term peace

The main purpose of this research was to understand the civil war in Sierra Leone and its antecedents, and to analyse the package of reconstruction reforms which came along in the post-war era and their relevance for and impact on the local challenges for longer term peace. Continued corruption among the political class, the persistent disenfranchisement of important social groups, and emerging tensions along political party lines suggested that, ten years on from the Lomé Peace Accord, there may have been a malaise in the peacebuilding plan. To investigate the complex issues, and to support the hypothesis that the model for reconstruction was not best suited to local conditions and local priorities, the work first made a deep interrogation of the historic political, cultural and economic factors which led to the violent conflict. This scrutiny of the local experience allowed the conceptualisation of a germane 'framework for peace' which represented the most pressing priorities of the local community and the central challenges for peace. The framework reflected the main concerns of the local populace and was used as an analytical tool to better understand the relevance of the model for reconstruction vis-à-vis the local context. Through a critical analysis of the post-war reforms and their impact on the social dimensions of recovery, in particular macro-economic reforms and the promotion of democracy, conclusions were drawn about the appropriateness and efficacy of the model of reconstruction experienced in Sierra Leone and how it supported local priorities for peace. The enquiry found that, in general, the model for reconstruction was not best suited to the local context because of its inflexibility to support the local peacebuilding and its many challenges. In some ways the model for reconstruction heightened residual tensions from the conflict because it failed to address key issues for reform such as governance and social justice.EThOS - Electronic Theses Online ServiceEconomic and Social Research CouncilGBUnited Kingdo

Could neonatal disseminated herpes simplex virus infections be treated earlier?

Introduction. Neonatal disseminated herpes simplex virus (HSV) infection can cause rapidly progressive multiple organ failure with an 85% mortality if untreated. Early recognition and treatment may improve outcome [N Engl J Med 324(1991)450]. Objectives. (i) To determine the number and presentation of neonates with disseminated HSV admitted to an intensive care unit. (ii) To determine paediatric Specialist Registrar (SpR) awareness of the diagnosis and management of a typical potential case of neonatal disseminated HSV. Methods. (i) A 10-year review of case notes of neonates admitted to the intensive care unit (ICU) at Great Ormond Street Hospital. (ii) A telephone questionnaire of 18on-call 19 Paediatric SpR's in the London area. Results. Eight cases of confirmed disseminated HSV infection were identified. All died. Each case followed a similar clinical course with presentation between days 5 139 of life (median day 7). A short prodrome preceded the rapid development of disseminated intravascular coagulopathy (DIC), hepatitis and multiple organ failure. Only three cases received antiviral treatment in the first 24 h after hospital admission. None of the 30 registrars who were interviewed initially considered disseminated HSV in the differential diagnosis of a 7-day-old baby presenting with non-specific signs of sepsis. Only 4/30 referring unit protocols included disseminated HSV in the differential diagnosis of neonatal sepsis. Conclusions. HSV infection should be considered in the differential diagnosis of the acutely unwell neonate. This condition is rare but well documented in the literature. Effective antiviral therapies exist but are often not started early in the clinical course. Awareness of this condition needs to be increased

Gender Equity in Australian Health Leadership

Objective: To ascertain the gender distribution across public health boards in Australia. Design & Setting: Analysis of data and information obtained from a cross sectional audit of online publicly listed health boards within Australia from October to December 2019. Results: The majority of public health boards have close to equal representation of women as board members however women are underrepresented in Chair roles. Victoria has significantly more women on health boards, whereas New South Wales has significantly less women on health boards and in Chair positions.  Conclusions: Further efforts are required to drive gender equity in senior leadership roles in public health boards across Australi

Définitions de la culture visuelle II : Utopies modernistes -Postformalisme et pureté de la vision = Definitions of Visual Culture II : Modernist Utopias - Postformalism and Pure Visuality

Nine texts (one of which is in French only) tackle Michael Fried's positions towards Greenbergian formalism, the avatars of the "visual object" and ocularcentrism, the meaning attached to picture hanging in an exhibition, strategies of mimicry and sexual identity, the "silence of the visual artwork", Barthes' conception of the filmic image, and the properties of Euroethnic art. Biographical notes on the authors. Circa 200 bibl. ref

Vacuum induced dehydration of swollen poly(methoxy diethylene glycol acrylate) and polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene films probed by in-situ neutron reflectivity

The isothermal vacuum-induced dehydration of thin films made of poly(methoxy diethylene glycol acrylate) (PMDEGA), which were swollen under ambient conditions, is studied. The dehydration behavior of the homopolymer film as well as of a nanostructured film of the amphiphilic triblock copolymer polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene, abbreviated as PS-b-PMDEGA-b-PS, are probed, and compared to the thermally induced dehydration behavior of such thin thermo-responsive films when they pass through their LCST-type coil-to globule collapse transition. The dehydration kinetics is followed by in-situ neutron reflectivity measurements. Contrast results from the use of deuterated water. Water content and film thickness are significantly reduced during the proce ss, which can be explained by Schott second order kinetics theory for both films. The water content of the dehydrated equilibrium state from this model is very close to the residual water content obtained from the final static measurements, indicating that residual water still remains in the film even after prolonged exposure to the vacuum. In the PS-b-PMDEGA-b-PS film that shows micro-phase separation, the hydrophobic PS domains modify the dehydration process by hindering the water removal, and thus retarding dehydration by about 30%. Whereas residual water remains tightly bound in the PMDEGA domains, water is completely removed from the PS domains of the block copolymer film