10 research outputs found
Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I)
Sensory abnormalities are a key feature of Complex Regional Pain Syndrome (CRPS). In order to characterise these changes in patients suffering from acute or chronic CRPS I, we used Quantitative Sensory Testing (QST) in comparison to an age and gender matched control group
Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells
Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity
Spirituality in Medical Education: Global Reality?
We aim to evaluate studies dealing with the incorporation of spirituality in medical education and to list the most scientific productive countries in this field. A bibliographical review was carried out. the final sample comprised 38 articles, which were divided into sub-topics for a clearer description. From these articles, 31 (81.5%) were provided by US medical schools, 3 (7.8%) by Canadian medical schools and 4 (10.5%) from other countries. the studies in this review indicate a predominance of studies related to health/medicine and spirituality in US and Canadian medical schools. New studies outside North America are needed in order to address what is being taught, whether courses are evaluated and what is the student and faculty opinions regarding this educational topic in multiple cultures.SĂŁo Paulo Med Spiritist Assoc, BR-04520000 SĂŁo Paulo, BrazilUniversidade Federal de SĂŁo Paulo, SĂŁo Paulo, BrazilGeorge Washington Univ, Washington, DC USAUniversidade Federal de SĂŁo Paulo, SĂŁo Paulo, BrazilWeb of Scienc
A genome-wide association study of metabolic traits in human urine
We present a genome-wide association study of metabolic traits in human urine, designed to investigate the detoxification capacity of the human body. Using NMR spectroscopy, we tested for associations between 59 metabolites in urine from 862 male participants in the population-based SHIP study. We replicated the results using 1,039 additional samples of the same study, including a 5-year follow-up, and 992 samples from the independent KORA study. We report five loci with joint P values of association from 3.2 × 10(-19) to 2.1 × 10(-182). Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria. Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria