Democracy At Stake in the Digital Age: Engaging in the Net Neutrality Debate for the Preservation of Free Speech and the Redemption of Public Interest

Net neutrality is currently one of the most topical government policies up for debate. In the following paper, I will examine three cases in which net neutrality has been threatened by internet service providers and the Federal Communications Commission and reinforced by public interest groups, major website companies, and the public. The online regime has been a critical instrument in the outcome of all three cases, highlighting the role and influence of internet users in the virtual and physical public spheres. Some say that the battle is already lost. FCC Chairman Ajit Pai and his Republican majority in the agency are set on and have the capacity to push through legislation that will undo strict regulation of ISPs set by the Obama administration. The vote has yet to take place later this month, but the result should not detract the democratic nature and value from the decade-long debate. Net neutrality has been demonstrative of a civil society, one that uses all the tools, techniques, and platforms available to them in the fight against corporate interest. For its relation to First Amendment rights, its goals of redeeming public interest to rightful owners, and its use of new public spheres to organize civic participation, net neutrality is not only necessary for the success of the Internet, but the debate around it is also indicative of and essential to the growth of democratic debates around public policy

Segmented forefoot plate in basketball footwear: Does it influence performance and foot joint kinematics and kinetics?

This study examined the effects of shoes’ segmented forefoot stiffness on athletic performance and ankle and metatarsophalangeal joint kinematics and kinetics in basketball movements. Seventeen university basketball players performed running vertical jumps and 5-msprints atmaximumeffort with 3 basketball shoes of various forefoot plate conditions (medial plate, medial + lateral plates, and no-plate control). One-way repeated measures ANOVAs were used to examine the differences in athletic performance, joint kinematics, and joint kinetics among the 3 footwear conditions (α = .05). Results indicated that participants wearing medial + lateral plates shoes demonstrated 2.9% higher jump height than those wearing control shoes (P = .02), but there was no significant differences between medial plate and control shoes (P \u3e .05). Medial plate shoes produced greater maximum plantar flexion velocity than the medial + lateral plates shoes (P \u3c .05) during sprinting. There were no significant differences in sprint time. These findings implied that inserting plates spanning both the medial and lateral aspects of the forefoot could enhance jumping, but not sprinting performances. The use of a medial plate alone, although induced greater plantar flexion velocity at the metatarsophalangeal joint during sprinting, was not effective in improving jump heights or sprint times

On the chances and challenges of combining electron-collecting nPOLO and hole-collecting Al-p+ contacts in highly efficient p-type c-Si solar cells

ISFH is following a distinct cell development roadmap, which comprises—as a short-term concept—the combination of an n-type doped electron-collecting poly-Si on oxide (POLO) junction with an Al-alloyed p+ junction for hole collection. This combination can be integrated either in front- and back-contacted back junction cells (POLO-BJ) or in interdigitated back-contacted cells (POLO-IBC). Here, we present recent progress with these two cell concepts. We report on a certified M2-sized 22.9% efficient POLO-BJ cell with a temperature coefficient TCη of only −(0.3 ± 0.02) %rel/K and a certified 23.7% (4 cm2 d.a.) efficient POLO-IBC cell. We discuss various specific conceptual aspects of this technology and present a simulation-based sensitivity analysis for quantities related to the quality of the hole-collecting alloyed Al-p+ junction which are subject to continuous improvement and thus hard to predict exactly. We report that the measured pseudo fill factor values decrease more due to metallization than would be expected from recombination in the metallized regions with an ideality factor of one only. The gap to pseudo fill factor values that are theoretically achievable at the respective open-circuit voltages is 1.1%abs (Ga-doped wafer) for POLO-IBC and 1.4%abs (B-doped wafer) to 2%abs (Ga-doped wafer) for POLO-BJ. With an embedded blocking layer for Ag crystallites in the poly-Si, we present a concept to reduce this gap

A transcriptomic analysis of the adult stage of the bovine lungworm, Dictyocaulus viviparus

<p>Abstract</p> <p>Background</p> <p>Lungworms of the genus <it>Dictyocaulus </it>(family Dictyocaulidae) are parasitic nematodes of major economic importance. They cause pathological effects and clinical disease in various ruminant hosts, particularly in young animals. <it>Dictyocaulus viviparus</it>, called the bovine lungworm, is a major pathogen of cattle, with severe infections being fatal. In this study, we provide first insights into the transcriptome of the adult stage of <it>D. viviparus </it>through the analysis of expressed sequence tags (ESTs).</p> <p>Results</p> <p>Using our EST analysis pipeline, we estimate that the present dataset of 4436 ESTs is derived from 2258 genes based on cluster and comparative genomic analyses of the ESTs. Of the 2258 representative ESTs, 1159 (51.3%) had homologues in the free-living nematode <it>C. elegans</it>, 1174 (51.9%) in parasitic nematodes, 827 (36.6%) in organisms other than nematodes, and 863 (38%) had no significant match to any sequence in the current databases. Of the <it>C. elegans </it>homologues, 569 had observed 'non-wildtype' RNAi phenotypes, including embryonic lethality, maternal sterility, sterility in progeny, larval arrest and slow growth. We could functionally classify 776 (35%) sequences using the Gene Ontologies (GO) and established pathway associations to 696 (31%) sequences in Kyoto Encyclopedia of Genes and Genomes (KEGG). In addition, we predicted 85 secreted proteins which could represent potential candidates for developing novel anthelmintics or vaccines.</p> <p>Conclusion</p> <p>The bioinformatic analyses of ESTs data for <it>D. viviparus </it>has elucidated sets of relatively conserved and potentially novel genes. The genes discovered in this study should assist research toward a better understanding of the basic molecular biology of <it>D. viviparus</it>, which could lead, in the longer term, to novel intervention strategies. The characterization of the <it>D. viviparus </it>transcriptome also provides a foundation for whole genome sequence analysis and future comparative transcriptomic analyses.</p

Making it RAIN: Using Remotely Accessible Instruments in Nanotechnology to Enhance High School Science Courses

The Remotely Accessible Instruments in Nanotechnology (RAIN) Network is a conglomerate of nineteen community colleges, four-year universities and high school sites that aims to enhance STEM learning by bringing advanced technologies to K-12 education. RAIN provides free remote access to instruments such as Scanning Electron, Atomic Force and Transmission Electron Microscopes, as well as Energy Dispersive and Infrared Spectroscopy. The following is a variety of experiments and an empirical formula lab that can be performed in a high school physical science or chemistry classroom that utilizes the RAIN Network

Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques.

Herpes simplex virus 2 (HSV-2) is a common sexually transmitted infection with a highly variable clinical course. Many infections quickly become subclinical, with episodes of spontaneous virus reactivation. To study host-HSV-2 interactions, an animal model of subclinical HSV-2 infection is needed. In an effort to develop a relevant model, rhesus macaques (RM) were inoculated intravaginally with two or three HSV-2 strains (186, 333, and/or G) at a total dose of 1 × 107 PFU of HSV-2 per animal. Infectious HSV-2 and HSV-2 DNA were consistently shed in vaginal swabs for the first 7 to 14 days after each inoculation. Proteins associated with wound healing, innate immunity, and inflammation were significantly increased in cervical secretions immediately after HSV-2 inoculation. There was histologic evidence of acute herpesvirus pathology, including acantholysis in the squamous epithelium and ballooning degeneration of and intranuclear inclusion bodies in epithelial cells, with HSV antigen in mucosal epithelial cells and keratinocytes. Further, an intense inflammatory infiltrate was found in the cervix and vulva. Evidence of latent infection and reactivation was demonstrated by the detection of spontaneous HSV-2 shedding post-acute inoculation (102 to 103 DNA copies/swab) in 80% of RM. Further, HSV-2 DNA was detected in ganglia in most necropsied animals. HSV-2-specifc T-cell responses were detected in all animals, although antibodies to HSV-2 were detected in only 30% of the animals. Thus, HSV-2 infection of RM recapitulates many of the key features of subclinical HSV-2 infection in women but seems to be more limited, as virus shedding was undetectable more than 40 days after the last virus inoculation.IMPORTANCE Herpes simplex virus 2 (HSV-2) infects nearly 500 million persons globally, with an estimated 21 million incident cases each year, making it one of the most common sexually transmitted infections (STIs). HSV-2 is associated with increased human immunodeficiency virus type 1 (HIV-1) acquisition, and this risk does not decline with the use of antiherpes drugs. As initial acquisition of both HIV and HSV-2 infections is subclinical, study of the initial molecular interactions of the two agents requires an animal model. We found that HSV-2 can infect RM after vaginal inoculation, establish latency in the nervous system, and spontaneously reactivate; these features mimic some of the key features of HSV-2 infection in women. RM may provide an animal model to develop strategies to prevent HSV-2 acquisition and reactivation