20M Sprint Capacity Test, a component of the Wheelchair Sports Performance Test : A Smartwheel ® Technology Field Validation Pilot Study

The purpose of this pilot study was to evaluate the relationships between the 20M Sprint Capacity Test utilizing SmartWheel® technology and other speed evaluation techniques. The goal of the 20M Sprint Capacity Test is to provide an objective protocol for coaches and players to measure speed, training, and performance growth. All participants (N = 17) performed two trials of the 20M Sprint Capacity test with the SmartWheel® placed on each side of a wheelchair, provided by the researcher. Results of this research focus on the potential relationships existing between the variables of push length (r = .650), push frequency (r = .594), peak force (r = .540), and speed performance as measured in meters/second by the SmartWheel®. The relationships between classification level of the athletes and speed in meters/second suggested a significant relationship (r = . 859). Due to the highly correlated relationship between classification level and speed, athlete classification (i.e., class) was partialed out to control for this relationship. When partial correlations were analyzed, push length and speed were no longer significantly correlated (r = .175, p = .532). Push frequency and speed (m/s) remained significantly correlated (r = .573, p = .026); however, peak force and speed (m/s) also were no longer significantly correlated (r = .464, p = .081). Additional research is needed to further validate these results and develop speed training assessment protocols for athletes with disabilities.  M.S

Examining the Effects of Casual Video Gameplay as an Intervention to Alleviate Symptoms of Depression on both Subjective and Objective Measures

Depression can be a debilitating illness that affects more than 300 million people worldwide. Although there are successful treatments for depression with pharmaceuticals and behavioral approaches such as psychotherapy, these approaches are often very costly and may carry a stigma of treatment for some individuals. The purpose of this dissertation study was to compare results of previously collected data that examine whether a prescribed regimen of casual videogame play (CVG) could reduce symptoms associated with depression. This dissertation specifically focused on comparing results of a study group and a comparison group on the self-report instrument, the Patient Health Questionnaire-9 (PHQ-9) as well as objectively measured changes in alpha wave, Electroencephalogram (EEG) data. Participants in the original study were screened for depression using the PHQ-9. There were a total of 57 participants who met the study inclusion criteria. Each participant that met the inclusion criteria was then randomized into either the comparison group (n=29) or the study group (n=28). Experimental group participants were prescribed to play one of three CVGs three times per week (with 24 hours between each session). This process occurred for 30 minutes each session, over a 1-month period. Comparison group participants reviewed the National Institute of Mental Health's webpage on depression during a pre-test and a post-test session. The participants in this group did not engage in any intervention over the one-month period of time between the pre-test and post-test sessions. A repeated-measures analysis of covariance (ANCOVA) was completed to examine three research questions between subjects at Time 1 and Time 3 to compare changes in depression symptoms on both subjective, self-report (PHQ-9) and objective alpha wave EEG measures. The CVGs used as the intervention factor were either Peggle, Bejeweled or Bookworm Adventure. Study analysis revealed significant decreases in depression symptoms reported in the study group on the PHQ-9 self-report scale. Results along the objective, EEG alpha wave scale revealed non-statistically significant changes. Potential reasons for the non-significant findings along with recommendations for future research are also discussed. Conclusions from this study found that a prescribed regimen of CVG may have potential as an intervention to help reduce symptoms of depression as measured on the PHQ-9 scale. Further research should consider examining intricacies of CVG play as a potential intervention to address symptoms related to depression. Findings also revealed that while EEG findings were not statistically significant, participants self-report responses were significant and may underscore the importance of individual's subjective feelings in the therapeutic process

Verbal Compliments As a Differential Source of Mate Poaching Threat For Men and Women

Two studies tested whether people feel threatened by another individual verbally complimenting their romantic partner. Such compliments may indicate that the other person is a potential rival who will try to poach their mate. Across two studies, women were more threatened than men when imagining another person complimenting their partner\u27s physical appearance. There were no sex differences in response to imagining another person complimenting their partner\u27s sense of humor. When another person compliments one\u27s partner\u27s physical appearance, this indicates that they may be sexually attracted to the partner. Mediation analyses revealed that the sex difference occurs because women believe men are more open to casual sex, and therefore more vulnerable to mate poaching when another person expresses sexual interest in them

Acceptability and Feasibility of a Meaning-Based Intervention for Patients With Advanced Cancer and Their Spouses A Pilot Study

Background: Constructing meaning in cancer leads to improved psychosocial outcomes for patients and survivors. Aim: We tested the feasibility and preliminary efficacy of a meaning-based intervention for couples. Design: The single-arm pilot study tested a 4-session, tailored, activities-based couple’s intervention. Setting/Participants: Twelve adults with incurable cancer and their partners participated either in a university office or at the couple’s home. Results: The study showed good feasibility. One of the two patients depressed at baseline was no longer depressed at postintervention. Patients’ threat appraisals decreased and transcendence increased. In partners, depression, anxiety, and challenge appraisal decreased; threat and secondary appraisals and peace with illness increased. Conclusions: Our findings suggest feasibility and efficacy, and further research and continued evaluation of this intervention are warranted

Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1

Acknowledgements This work was supported by grants from the Wellcome Trust (200855/Z/16/Z) to MFN and the BBSRC (BB/V010107/1) to MFN and BV. The authors thank Innes Jarmson for the generation of adeno-associated viruses.Peer reviewedPublisher PD

Generating topological order from a 2D cluster state using a duality mapping

In this paper we prove, extend and review possible mappings between the two-dimensional Cluster state, Wen's model, the two-dimensional Ising chain and Kitaev's toric code model. We introduce a two-dimensional duality transformation to map the two-dimensional lattice cluster state into the topologically-ordered Wen model. Then, we subsequently investigates how this mapping could be achieved physically, which allows us to discuss the rate at which a topologically ordered system can be achieved. Next, using a lattice fermionization method, Wen's model is mapped into a series of one-dimensional Ising interactions. Considering the boundary terms with this mapping then reveals how the Ising chains interact with one another. The relationships discussed in this paper allow us to consider these models from two different perspectives: From the perspective of condensed matter physics these mappings allow us to learn more about the relation between the ground state properties of the four different models, such as their entanglement or topological structure. On the other hand, we take the duality of these models as a starting point to address questions related to the universality of their ground states for quantum computation.Comment: 5 Figure

Intramolecular Friedel-Crafts Addition of Indoles to Tertiary Allylic Alcohols

An intermolecular Friedel-Crafts alkylation of indole and tertiary allylic alcohols has been developed. The allylic alcohols were synthesized using a two-step procedure, then exposure of these alcohols to diphenyl phosphate facilitated the desired annulation reaction. This reaction tolerated a variety of indole substitutions to yield 1H,2H,3H,4H-pyrido[1,2-a]indoles

The activity of cAMP-Phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus

The cyclic AMP phosphodiesterases type 4 (PDE4s) are expressed in a cell specific manner, with intracellular targeting directed by unique N-terminal anchor domains. All long form PDE4s are phosphorylated and activated by PKA phosphorylation within their upstream conserved region 1 (UCR1). Here, we identify and characterise a novel PKA site (serine 42) within the N-terminal region of PDE4D7, an isoform whose activity is known to be important in prostate cancer progression and ischemic stroke. In contrast to the UCR1 site, PKA phosphorylation of the PDE4D7 N-terminus appears to occur constitutively and inhibits PDE4 activity to allow cAMP signalling under basal conditions