Book review: Corporate citizen: new perspectives on the globalized rule of law edited by Oonagh E. Fitzgerald

In Corporate Citizen: New Perspectives on the Globalized Rule of Law, editor Oonagh E. Fitzgerald brings together contributors to explore how the notion of corporate global citizenship has enabled corporations to evade responsibilities and liabilities and block or weaken measures that might increase corporate accountability. This volume serves a valuable purpose in demonstrating the far-reaching and multi-faceted problems surrounding the governance of transnational corporations, writes Christie McLeod, and is recommended to anyone interested in corporate governance, corporate liability and corporate social responsibility. Corporate Citizen: New Perspectives on the Globalized Rule of Law. Oonagh E. Fitzgerald (eds). CIGI Press. 2020

The Human Rights-Based Approach to Carbon Finance by Damilola S. Olawuyi

Rising sea levels, changing rainfall patterns, annual average temperature increases, and other impacts of climate change threaten the security and livelihood of individuals around the world today.3 Projects intended to mitigate greenhouse gas emissions and lessen future impacts of climate change (“carbon projects”), however, can also cause significant harm

Does Climate Change Increase the Risk of Child Marriage? A Look at What We Know--And What We Don't--With Lessons from Bangladesh & Mozambique

While child marriages are almost always the result of multiple interconnected factors, this Article will examine the existing evidence of a connection between the impacts of climate change and child marriage and analyze some of the research and monitoring gaps. Are existing climate change policies, as well as measures taken to reduce and eliminate child marriage, addressing this link? What are the human rights obligations of governments to protect girls from child marriage, including in times of disaster? Part I of the Article summarizes the current state of research about the causes and consequences of child marriage, followed by a review of the available research on connections between child marriage and climate change. It will examine the extent to which evidence has been gathered on this topic and assess the different ways in which impacts of climate change have been found to influence decisions regarding child marriage. It will argue that, while there are significant gaps in the research, there is growing evidence that climate change may exacerbate the rate of child marriage. Part II presents two country-specific case studies of the potential connection between climate change and child marriage in Bangladesh and Mozambique, two countries that are highly vulnerable to climate change and have rates of child marriage among the highest in the world. It also reviews laws and policies adopted by Bangladesh and Mozambique to cope with climate change and to reduce child marriage, and what lessons these efforts provide for other countries facing similar challenges. Part III reviews relevant obligations of governments under international human rights law and within the international climate change regime. In Part IV, the Article proposes measures to ensure that climate change mitigation efforts are grounded in an understanding of the gendered ways in which climate change affects women and girls, including through increased child marriage, and that anti-child marriage efforts take into account the impacts of climate change

'Shooting in the dark': implications of the research-practice gap for enhancing research use in adult social care

Background: Despite calls for greater use of research and an appetite to do so within adult social care, a gap persists between research and practice. Aims and objectives: To explore views of adult social care staff about research and its application to everyday practice. To understand how these might impact upon research use capacity-building initiatives within adult social care organisations. Methods: Thematic analysis of semi-structured qualitative interviews with 25 staff members working within the adult social care departments of three English local authorities. Findings: Participants characterised research as feeling separate from practice. They reflected on their use of it in relation to pressures affecting adult social care and identified a lack of relevant research. Research benefiting service users, supporting individual practice or informing organisational decision-making was considered useful. However, research could also be viewed as a luxury where its findings were felt to represent an ‘ideal’ rather than real world of practice or did not accord with practice knowledge or local experience. Discussion and conclusions: While participants feel positively towards research, there remains a gap between these perceptions and its use in practice. There remains a need to improve research relevance and accessibility and to clarify its role in decision-making in social care, including where there is no evidence, where evidence challenges existing practice, or where the evidence base is growing. Collaborative partnerships between adult social care organisations, researchers and service users could help to narrow the research–practice gap and support the routine translation of research to practice

‘Shooting in the dark’: Implications of the research–practice gap for enhancing research use in adult social care

Background: Despite calls for greater use of research and an appetite to do so within adult social care, a gap persists between research and practice. Aims and objectives: To explore views of adult social care staff about research and its application to everyday practice. To understand how these might impact upon research use capacity-building initiatives within adult social care organisations. Methods: Thematic analysis of semi-structured qualitative interviews with 25 staff members working within the adult social care departments of three English local authorities. Findings: Participants characterised research as feeling separate from practice. They reflected on their use of it in relation to pressures affecting adult social care and identified a lack of relevant research. Research benefiting service users, supporting individual practice or informing organisational decision-making was considered useful. However, research could also be viewed as a luxury where its findings were felt to represent an ‘ideal’ rather than real world of practice or did not accord with practice knowledge or local experience. Discussion and conclusions: While participants feel positively towards research, there remains a gap between these perceptions and its use in practice. There remains a need to improve research relevance and accessibility and to clarify its role in decision-making in social care, including where there is no evidence, where evidence challenges existing practice, or where the evidence base is growing. Collaborative partnerships between adult social care organisations, researchers and service users could help to narrow the research–practice gap and support the routine translation of research to practice

Health Data Governance for Research Use in Alberta

Alberta has rich clinical and health services data held under the custodianship of Alberta Health and Alberta Health Services (AHS), which is not only used for clinical and administrative purposes but also disease surveillance and epidemiological research. Alberta is the largest province in Canada with a single payer centralised health system, AHS, and a consolidated data and analytics team supporting researchers across the province. This paper describes Alberta's data custodians, data governance mechanisms, and streamlined processes followed for research data access. AHS has created a centralised data repository from multiple sources, including practitioner claims data, hospital discharge data, and medications dispensed, available for research use through the provincial Data and Research Services (DRS) team. The DRS team is integrated within AHS to support researchers across the province with their data extraction and linkage requests. Furthermore, streamlined processes have been established, including: 1) ethics approval from a research ethics board, 2) any necessary operational approvals from AHS, and 3) a tripartite legal agreement dictating terms and conditions for data use, disclosure, and retention. This allows researchers to gain timely access to data. To meet the evolving and ever-expanding big-data needs, the University of Calgary, in partnership with AHS, has built high-performance computing (HPC) infrastructure to facilitate storage and processing of large datasets. When releasing data to researchers, the analytics team ensures that Alberta's Health Information Act's guiding principles are followed. The principal investigator also ensures data retention and disposition are according to the plan specified in ethics and per the terms set out by funding agencies. Even though there are disparities and variations in the data protection laws across the different provinces in Canada, the streamlined processes for research data access in Alberta are highly efficient

Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure

Thiopurine methyltransferase (Tpmt) is the primary enzyme responsible for deactivating thiopurine drugs. Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the treatment of cancer, organ transplant, and autoimmune disorders. Chronic thiopurine therapy has been linked to the development of brain cancer (most commonly astrocytomas), and Tpmt status has been associated with this risk. Therefore, we investigated whether the level of Tpmt protein activity could predict TG-associated cytotoxicity and DNA damage in astrocytic cells. We found that TG induced cytotoxicity in a dose-dependent manner in Tpmt+/+, Tpmt+/− and Tpmt−/− primary mouse astrocytes and that a low Tpmt phenotype predicted significantly higher sensitivity to TG than did a high Tpmt phenotype. We also found that TG exposure induced significantly more DNA damage in the form of single strand breaks (SSBs) and double strand breaks (DSBs) in primary astrocytes with low Tpmt versus high Tpmt. More interestingly, we found that Tpmt+/− astrocytes had the highest degree of cytotoxicity and genotoxicity (i.e., IC50, SSBs and DSBs) after TG exposure. We then used human glioma cell lines as model astroglial cells to represent high (T98) and low (A172) Tpmt expressers and found that A172 had the highest degree of cytoxicity and SSBs after TG exposure. When we over-expressed Tpmt in the A172 cell line, we found that TG IC50 was significantly higher and SSB's were significantly lower as compared to mock transfected cells. This study shows that low Tpmt can lead to greater sensitivity to thiopurine therapy in astroglial cells. When Tpmt deactivation at the germ-line is considered, this study also suggests that heterozygosity may be subject to the greatest genotoxic effects of thiopurine therapy

Conversion of t11t13 CLA into c9t11 CLA in Caco-2 Cells and Inhibition by Sterculic Oil

Background : Conjugated linoleic acids (CLA), and principally c9t11 CLA, are suspected to have numerous preventive properties regarding non-infectious pathologies such as inflammatory diseases, atherosclerosis and several types of cancer. C9t11 CLA is produced in the rumen during biohydrogenation of linoleic acid, but can also be synthesized in mammalian tissues from trans-vaccenic acid (C18:1 t11) through the action of delta-9 desaturase (D9D). For several years, it is also known that c9t11 CLA can be synthesized from conjugated linolenic acids (CLnA), i.e. c9t11c13 CLnA and c9t11t13 CLnA. This study aimed at investigating to which extent and by which route c9t11 CLA can be produced from another isomer of CLA, the t11t13 CLA that is structurally very similar to c9t11t13 CLnA, in Caco-2 cells