Uji Diagnostik Prokalsitonin Dibanding Kultur Darah Sebagai Baku Emas Untuk Diagnostik Sepsis Bakterial Di Rsup Dr.kariadi

Background: Sepsis is a serious health problem arround the world because the late diagnosis can threathen life. Diagnosis by blood culture as the gold standard need 2-3 days.That's why more rapid and accurate diagnostic method are needed which is Procalcitonin test This study was aim to determine sensitivity,spesificity,positive predictive value,and negative predictive value of Procalcitonin test compared to blood culture.Methods: Data used in this study is patients diagnosed sepsis clinically in Kariadi hospital Semarang in 2011. Study subjects totaled 27 people aged less than 1 year till 87 years. Results of procalcitonin test with determined cut- off point compared with the blood culture results , then assess the diagnostic procalcitonin .Results: At 2 ng/ml obtained sensitivity 66,6%,spesificity 44,4%, positive predictive value 37,5%, negative predictive value 72,7%,and accuration 51,85%.Conclusion: The sensitivity,spesificity,positive predictive value,negative predictive value,and accuration of Procalcitonin test for diagnosing sepsis in Kariadi hospital are low

Modelling the atomic structure of very high-density amorphous ice

The structure of very high-density amorphous (VHDA) ice has been modelled by positionally disordering three crystalline phases, namely ice IV, VI and XII. These phases were chosen because only they are stable or metastable in the region of the ice phase diagram where VHDA ice is formed, and their densities are comparable to that of VHDA ice. An excellent fit to the medium range of the experimentally observed pair-correlation function g(r) of VHDA ice was obtained by introducing disorder into the positions of the H2O molecules, as well as small amounts of molecular rotational disorder, disorder in the O--H bond lengths and disorder in the H--O--H bond angles. The low-k behaviour of the experimental structure factor, S(k), is also very well reproduced by this disordered-crystal model. The fraction of each phase present in the best-fit disordered model is very close to that observed in the probable crystallization products of VHDA ice. In particular, only negligible amounts of ice IV are predicted, in accordance with experimental observation.Comment: 4 pages, 3 figures, 1 table, v2: changes made in response to referees' comments, the justification for using certain ice phases is improved, and ice IV is now disordered as wel

Behavioural Consequences of Frontal Cortex Grafts and Enriched Environments after Sensorimotor Cortex Lesions

Past studies have experienced difficulty in achieving graft survival and behavioural recovery after sensorimotor cortex lesions. In the present work, adult female rats trained preoperatively to cross a narrow beam for food reward were maintained in standard group cages or an enriched environment, commencing one week after a unilateral lesion. One month post-lesion, half of these rats received multiple suspension grafts of (E20) fetal frontal cortex, placed adjacent to the lesion cavity, and 8 days later recovery of beam-walking skills was examined for a six-week period. The grafts survived in all cases with an appropriate lesion, a notable result given the one month lesion-graft delay, but graft volume was not influenced by postoperative environment. The substantial lesion-induced deficits evident just prior to differential housing showed a marked reduction by the start of post-graft testing, but relative to intact controls a persistent deficit in foot slip errors occurred in all lesion groups. Irrespective of graft status, postoperative enrichment prevented the occurrence of severe foot slips, especially early in retraining. The frontal grafts, however, enhanced beam-walking recovery by reducing the overall frequency of foot slips on early post-grafting sessions, an effect we suggest is related to graft-derived trophic influences, but this measure was not significantly improved by postoperative enrichment

Bluetongue virus infection creates light averse Culicoides vectors and serious errors in transmission risk estimates.

BackgroundPathogen manipulation of host behavior can greatly impact vector-borne disease transmission, but almost no attention has been paid to how it affects disease surveillance. Bluetongue virus (BTV), transmitted by Culicoides biting midges, is a serious disease of ruminant livestock that can cause high morbidity and mortality and significant economic losses. Worldwide, the majority of surveillance for Culicoides to assess BTV transmission risk is done using UV-light traps. Here we show that field infection rates of BTV are significantly lower in midge vectors collected using traps baited with UV light versus a host cue (CO2).MethodsWe collected Culicoides sonorensis midges in suction traps baited with CO2, UV-light, or CO2 + UV on three dairies in southern California to assess differences in the resulting estimated infection rates from these collections. Pools of midges were tested for BTV by qRT-PCR, and maximum likelihood estimates of infection rate were calculated by trap. Infection rate estimates were also calculated by trapping site within a dairy. Colonized C. sonorensis were orally infected with BTV, and infection of the structures of the compound eye was examined using structured illumination microscopy.ResultsUV traps failed entirely to detect virus both early and late in the transmission season, and underestimated virus prevalence by as much as 8.5-fold. CO2 + UV traps also had significantly lower infection rates than CO2-only traps, suggesting that light may repel infected vectors. We found very high virus levels in the eyes of infected midges, possibly causing altered vision or light perception. Collecting location also greatly impacts our perception of virus activity.ConclusionsBecause the majority of global vector surveillance for bluetongue uses only light-trapping, transmission risk estimates based on these collections are likely severely understated. Where national surveillance programs exist, alternatives to light-trapping should be considered. More broadly, disseminated infections of many arboviruses include infections in vectors' eyes and nervous tissues, and this may be causing unanticipated behavioral effects. Field demonstrations of pathogen-induced changes in vector behavior are quite rare, but should be studied in more systems to accurately predict vector-borne disease transmission

Choosing an Evaluation Theory: A Supplement to Evaluation Roots (3rd Edition)

Background: Unlike scientific theories, evaluation theories are prescriptive: a set of actions and approaches that should be followed when conducting an evaluation. While evaluation theorists have offered a variety of writings describing their theories and approaches, few have offered a specific outline of what the theory looks like in practice. Thus, Alkin and Christie formulated a book to aid evaluators in how to apply theories in evaluations (Alkin & Christie, forthcoming). This book culminates in a series of prototypes that outline each theory’s goals, appropriate contexts, prescriptions, and observable actions in application. Purpose: In order to aid evaluators in applying theories, this article seeks to provide a basis for comparison that can be used to help evaluators select which theory would be most appropriate in their practice. Setting: This comparison can be applied in any setting where evaluations fit the context prescribed by each of the theories. Intervention: Not applicable. Research Design: Not applicablre. Data Collection and Analysis: Not applicable. Findings: In order for theories to influence practice effectively, theories must be displayed in a way that allows for easy comparison. This comparison of three theory prototypes demonstrates that prototypes can be an effective way for selecting a prescriptive theory when conducting an evaluation. Keywords: prescriptive theories; practice; empowerment evaluation; learning centered model; developmental evaluatio

Practices of strength and conditioning coaches: a snapshot from different sports, countries and expertise levels

This study describes the practices of strength and conditioning coaches (SCCs) from different sports, countries and expertise levels. One-hundred and fifty-six SCCs (31.9 + 8.9 years old) completed an online survey, consisting of 40 questions (36 fixed response and 4 open-ended), with eight sections: (a) background information, (b) muscular strength and power development, (c) speed development, (d) plyometrics, (e) flexibility development, (f) physical testing, (g) technology use, and (h) programming and any additional comments. Responses were received from 48 sports and 17 countries. This study provides exploratory evidence incorporating responses primarily in soccer (45%), track and field (30%), volleyball (23%), golf (17%) and tennis (17%). A Bachelor’s degree or higher were held by 99% of SCCs, of which 94% were in a sports science related field, and 71% held a strength and conditioning related certification or accreditation. Periodization strategies and physical testing were used by 94% of SCCs. The hang clean (82%), power clean (76%), and clean high pull (63%) were the most commonly prescribed Olympic Weightlifting exercises. Multiple hops/lunges (84%) were the most commonly prescribed plyometrics exercises. For open ended questions, 40% of SCCs wanted to integrate more technology into their programs, whereas, 30% of coaches believed technology will be the main future trend in strength and conditioning. SCCs from different sports, countries and expertise levels can use the information presented in this study to review their current practices and potentially provide a source of new ideas for diversifying or modifying future practices too