Late Miocene to early Pliocene biofacies of Wanganui and Taranaki Basins, New Zealand: Applications to paleoenvironmental and sequence stratigraphic analysis

The Matemateaonga Formation is late Miocene to early Pliocene (upper Tongaporutuan to lower Opoitian New Zealand Stages) in age. The formation comprises chiefly shellbeds, siliciclastic sandstone, and siltstone units and to a lesser extent non-marine and shallow marine conglomerate and rare paralic facies. The Matemateaonga Formation accumulated chiefly in shelf paleoenvironments during basement onlap and progradation of a late Miocene to early Pliocene continental margin wedge in the Wanganui and Taranaki Basins. The formation is strongly cyclothemic, being characterised by recurrent vertically stacked facies successions, bounded by sequence boundaries. These facies accumulated in a range of shoreface to mid-outer shelf paleoenvironments during conditions of successively oscillating sea level. This sequential repetition of facies and the biofacies they enclose are the result of sixth-order glacio-eustatic cyclicity. Macrofaunal associations have been identified from statistical analysis of macrofossil occurrences collected from multiple sequences. Each association is restricted to particular lithofacies and stratal positions and shows a consistent order and/or position within the sequences. This pattern of temporal paleoecologic change appears to be the result of lateral, facies-related shifting of broad biofacies belts, or habitat-tracking, in response to fluctuations of relative sea level, sediment flux, and other associated paleoenvironmental variables. The associations also show strong similarity in terms of their generic composition to biofacies identified in younger sedimentary strata and the modern marine benthic environment in New Zealand

Changing teachers, changing Scotland?

Teacher professionalism and development are central to the study of education across the globe, and in particular, are central to concepts of educational reform and change. This article explores the centrality of teacher professionalism and development to the three substantive networks of the Applied Educational Research Scheme (AERS) in Scotland, examining how they feature within discussions about: school management and governance; schools and social capital; and teachers as learners. The article explores each of these contexts in turn concluding with consideration of how the work of the three AERS networks might help to understand and inform an agenda for change

A longitudinal study looking at the impact of COVID-19 restrictions and transitions on psychological distress in caregivers of children with Intellectual Disabilities in the UK

Introduction: The current study explored longitudinally whether child behaviours that challenge and caregiver coping strategies was associated with psychological distress in caregivers of children with and without intellectual disability during and after lockdown. Method: An online survey was completed by caregivers who had children with and without intellectual disability during Time Period 1 (T1; August-December 2021, n = 171) and then again during Time Period 2 (T2; January-March 2022, n = 109). Results: Child behaviours that challenge and caregiver psychological distress reduced in T2 compared to T1. Child behaviours that challenge, emotion focused coping and avoidant coping was associated distress at both time points in caregivers of children with and without intellectual disabilities. Conclusions: The study shows that both child behaviours that challenge and caregiver psychological distress reduced as lockdown ended. However, caregiver coping strategies may have contributed to psychological distress, which has implications for interventions and support for caregivers

Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials.

Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn2+) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges

Zinc associated nanomaterials and their intervention in emerging respiratory viruses:Journey to the field of biomedicine and biomaterials

Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn(2+)) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges

Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine

Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA). Recent data have led to a debate about the principal pathway of nicotine action: direct stimulation of the DAergic cells through nAChR activation, or disinhibition mediated through desensitization of nAChRs on GABAergic interneurons. We use a computational model of the VTA circuitry and nAChR function to shed light on this issue. Our model illustrates that the α4β2-containing nAChRs either on DA or GABA cells can mediate the acute effects of nicotine. We account for in vitro as well as in vivo data, and predict the conditions necessary for either direct stimulation or disinhibition to be at the origin of DA activity increases. We propose key experiments to disentangle the contribution of both mechanisms. We show that the rate of endogenous acetylcholine input crucially determines the evoked DA response for both mechanisms. Together our results delineate the mechanisms by which the VTA mediates the acute rewarding properties of nicotine and suggest an acetylcholine dependence hypothesis for nicotine reinforcement.Peer reviewe

The Vehicle, Spring 2009

Table of Contents Idyllic Has an EndJustine Fittonpage 28 The RemedyJosh Boykinpage 29 True NatureStephen Garciapage 30 We Are All Eaters of SoulsDan Davispage 31 Scarlet on the WindJustin Sudkamppage 34 IlluminatedRashelle McNairpage 35 Lightning RodKim Hunter-Perkinspage 36 TrialDan Davispage 49 Dear GodKristi Kohlenbergpage 50 A Cheap Metaphor Is What We Have for DeathKeith Stewartpage 51 Sad MoonJennifer O\u27Neilpage 52 The Transported ManStephen Garciapage 61 Divine InsanityGrace Lawrencepage 62 Moonglow MemoriesJustin Sudkamppage 63 Poetry The Habits of HusbandsKim Hunter-Perkinspage 4 Young AmericanMaria Rhodespage 5 Kevin Doesn\u27t Live Here AnymoreJustine Fittonpage 6 Summer VacationMary Lieskepage 8 PerfectChristie Cheatlepage 9 Hate for OneMiranda Whitepage 10 The Witch\u27s GraveDan Davispage 16 Medicine WomanLindsey Durbinpage 18 Epistle to a BombshellKim Hunter-Perkinspage 19 GuardedAaron Dillardpage 20 Lean and Hungry in YesteryearTim Ernstpage 21 Dirty TearsBrittany Morganpage 27 I Left the Radio OnSerena Heathpage 83 Untitled, for CourtneyKellen Fasnachtpage 84 Ermine DriveStephen Garciapage 85 Prose TwigDaniel Paquinpage 11 Coyote MoonDan Davispage 22 BloodGretchen Schaiblepage 32 IntroductionSam Sottosantopage 53 The Guitar ManDan Davispage 75 Art Picasso InspirationAlycia Rockeycover StageSarah Fairchildpage 37 ConnectedBrittany Morganpage 65 SpringAnthony Travis Shootpage 66 BodhisattvaSarah Fairchildpage 67 What About Love?Justin Sudkamppage 68 Angry MoonJennifer O\u27Neilpage 69 HauntedKellen Fasnachtpage 70 Haiku #1Justin Sudkamppage 72 ImmobileRashelle McNairpage 73 The ChurningJosh Boykinpage 74 The Old Boat DockJosh Boykinpage 79 Saltwater RaindropsTim Ernstpage 80 Slow MotionGrace Lawrencepage 81 Solid AdviceAnthony Travis Shootpage 82 TreeAlycia Rockeypage 38 TireSarah Fairchildpage 39 What to WearKristy Pearsonpage 40 Figure 1Sean Walkerpage 41 GreenhouseAlycia Rockeypage 42 RomeAlycia Rockeypage 43 Me at the Lamp PostElizabeth Surbeckpage 44 Little Miss LizKristy Pearsonpage 45 DoudnaAlycia Rockeypage 46 FlagAlycia Rockeypage 47 Flag ProtestAlycia Rockeypage 48 Features Note From the EditorRebecca Griffithpage 1 Fall 2008-Spring 2009 Vehicle Award Winnerspage 2 James K. Johnson Creative Writing Awardpage 86 Winning Entry (Nonfiction)Daniel Paquinpage 87 Winning Entries (Poetry)Anthony Travis Shootpage 98 Contributorspage 103https://thekeep.eiu.edu/vehicle/1091/thumbnail.jp