Etat de santé et rapport aux soins des personnes en situation précaire (étude des consultations de médecine générale à l'association Baptiste d'entraide de la jeunesse de Lille)

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Destination Memory in Korsakoff's Syndrome

BACKGROUND: Context memory, or the ability to remember the context in which an episodic event has occurred (e.g., where and when an event took place), has been found to be compromised in Korsakoff's syndrome. This study examined whether a similar deficit would be observed for destination memory, that is, the ability to remember to whom an information was previously transmitted. METHODS: Patients with Korsakoff's syndrome and healthy controls were instructed to tell proverbs to pictures of celebrities. In a subsequent recognition test, they had to indicate to which celebrity they had previously told the proverbs. Participants also completed a neuropsychological battery including a binding task in which they were required to associate letters with their correspondent locations to assess context memory. RESULTS: Results showed worse binding and destination memory in patients with Korsakoff's syndrome than in controls. In the Korsakoff group, destination memory was significantly correlated with and predicted by performances on the binding task. CONCLUSIONS: The binding process seems to be impaired in Korsakoff's syndrome, a deficit that may account for the destination memory compromise in the syndrome, and probably, for the difficulty to retrieve the "where and when" of an encountered event

La « recommandation temporaire d’utilisation » sur le baclofène : point de vue des prescripteurs du dispositif CAMTEA

L’utilisation du baclofène hautes-doses dans l’alcoolo-dépendance a émergé en France depuis 2008 à partir de constatations empiriques, et cette utilisation se fait toujours aujourd’hui en dehors de l’autorisation de mise sur le marché. Néanmoins, en raison de la diffusion rapide de cette pratique de prescription, les autorités françaises de santé ont décidé de l’encadrer grâce à une mesure régulatoire exceptionnelle appelée « recommandation temporaire d’utilisation » (RTU). Les prescripteurs de baclofène de CAMTEA, un dispositif collégial de prescription encadré de baclofène hautes-doses mis en place bien avant la RTU, discutent ici des avantages et des inconvénients de cette mesure et de l’applicabilité de ses différentes modalités dans la pratique clinique quotidienne