9,045 research outputs found
A Particle-based Multiscale Solver for Compressible Liquid-Vapor Flow
To describe complex flow systems accurately, it is in many cases important to
account for the properties of fluid flows on a microscopic scale. In this work,
we focus on the description of liquid-vapor flow with a sharp interface between
the phases. The local phase dynamics at the interface can be interpreted as a
Riemann problem for which we develop a multiscale solver in the spirit of the
heterogeneous multiscale method, using a particle-based microscale model to
augment the macroscopic two-phase flow system. The application of a microscale
model makes it possible to use the intrinsic properties of the fluid at the
microscale, instead of formulating (ad-hoc) constitutive relations
Universal Quantum Computation with Continuous-Variable Cluster States
We describe a generalization of the cluster-state model of quantum
computation to continuous-variable systems, along with a proposal for an
optical implementation using squeezed-light sources, linear optics, and
homodyne detection. For universal quantum computation, a nonlinear element is
required. This can be satisfied by adding to the toolbox any single-mode
non-Gaussian measurement, while the initial cluster state itself remains
Gaussian. Homodyne detection alone suffices to perform an arbitrary multi-mode
Gaussian transformation via the cluster state. We also propose an experiment to
demonstrate cluster-based error reduction when implementing Gaussian
operations.Comment: 4 pages, no figure
Limits of economy and fidelity for programmable assembly of size-controlled triply-periodic polyhedra
We propose and investigate an extension of the Caspar-Klug symmetry
principles for viral capsid assembly to the programmable assembly of
size-controlled triply-periodic polyhedra, discrete variants of the Primitive,
Diamond, and Gyroid cubic minimal surfaces. Inspired by a recent class of
programmable DNA origami colloids, we demonstrate that the economy of design in
these crystalline assemblies -- in terms of the growth of the number of
distinct particle species required with the increased size-scale (e.g.
periodicity) -- is comparable to viral shells. We further test the role of
geometric specificity in these assemblies via dynamical assembly simulations,
which show that conditions for simultaneously efficient and high-fidelity
assembly require an intermediate degree of flexibility of local angles and
lengths in programmed assembly. Off-target misassembly occurs via incorporation
of a variant of disclination defects, generalized to the case of hyperbolic
crystals. The possibility of these topological defects is a direct consequence
of the very same symmetry principles that underlie the economical design,
exposing a basic tradeoff between design economy and fidelity of programmable,
size controlled assembly.Comment: 15 pages, 5 figures, 6 supporting movies (linked), Supporting
Appendi
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Charge Transport and Rectification in Arrays of SAM-Based Tunneling Junctions
This paper describes a method of fabrication that generates small arrays of tunneling junctions based on self-assembled monolayers (SAMs); these junctions have liquid-metal top-electrodes stabilized in microchannels and ultraflat (template-stripped) bottom-electrodes. The yield of junctions generated using this method is high (70−90%). The junctions examined incorporated SAMs of alkanethiolates having ferrocene termini (11-(ferrocenyl)-1-undecanethiol, SCFc); these junctions rectify currents with large rectification ratios (R), the majority of which fall within the range of 90−180. These values are larger than expected (theory predicts R ≤ 20) and are larger than previous experimental measurements. SAMs of n-alkanethiolates without the Fc groups (SCCH, with n = 12, 14, 16, or 18) do not rectify (R ranged from 1.0 to 5.0). These arrays enable the measurement of the electrical characteristics of the junctions as a function of chemical structure, voltage, and temperature over the range of 110−293 K, with statistically large numbers of data (N = 300−800). The mechanism of rectification with Fc-terminated SAMs seems to be charge transport processes that change with the polarity of bias: from tunneling (at one bias) to hopping combined with tunneling (at the opposite bias).Chemistry and Chemical Biolog
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Intrathecal B-cell activation in LGI1 antibody encephalitis.
ObjectiveTo study intrathecal B-cell activity in leucine-rich, glioma-inactivated 1 (LGI1) antibody encephalitis. In patients with LGI1 antibodies, the lack of CSF lymphocytosis or oligoclonal bands and serum-predominant LGI1 antibodies suggests a peripherally initiated immune response. However, it is unknown whether B cells within the CNS contribute to the ongoing pathogenesis of LGI1 antibody encephalitis.MethodsPaired CSF and peripheral blood (PB) mononuclear cells were collected from 6 patients with LGI1 antibody encephalitis and 2 patients with other neurologic diseases. Deep B-cell immune repertoire sequencing was performed on immunoglobulin heavy chain transcripts from CSF B cells and sorted PB B-cell subsets. In addition, LGI1 antibody levels were determined in CSF and PB.ResultsSerum LGI1 antibody titers were on average 127-fold higher than CSF LGI1 antibody titers. Yet, deep B-cell repertoire analysis demonstrated a restricted CSF repertoire with frequent extensive clusters of clonally related B cells connected to mature PB B cells. These clusters showed intensive mutational activity of CSF B cells, providing strong evidence for an independent CNS-based antigen-driven response in patients with LGI1 antibody encephalitis but not in controls.ConclusionsOur results demonstrate that intrathecal immunoglobulin repertoire expansion is a feature of LGI1 antibody encephalitis and suggests a need for CNS-penetrant therapies
Human Performance Models of Pilot Behavior
Five modeling teams from industry and academia were chosen by the NASA Aviation Safety and Security Program to develop human performance models (HPM) of pilots performing taxi operations and runway instrument approaches with and without advanced displays. One representative from each team will serve as a panelist to discuss their team s model architecture, augmentations and advancements to HPMs, and aviation-safety related lessons learned. Panelists will discuss how modeling results are influenced by a model s architecture and structure, the role of the external environment, specific modeling advances and future directions and challenges for human performance modeling in aviation
Scalable Focused Ion Beam Creation of Nearly Lifetime-Limited Single Quantum Emitters in Diamond Nanostructures
The controlled creation of defect center---nanocavity systems is one of the
outstanding challenges for efficiently interfacing spin quantum memories with
photons for photon-based entanglement operations in a quantum network. Here, we
demonstrate direct, maskless creation of atom-like single silicon-vacancy (SiV)
centers in diamond nanostructures via focused ion beam implantation with nm lateral precision and nm positioning accuracy relative to a
nanocavity. Moreover, we determine the Si+ ion to SiV center conversion yield
to and observe a 10-fold conversion yield increase by additional
electron irradiation. We extract inhomogeneously broadened ensemble emission
linewidths of GHz, and close to lifetime-limited single-emitter
transition linewidths down to MHz corresponding to -times
the natural linewidth. This demonstration of deterministic creation of
optically coherent solid-state single quantum systems is an important step
towards development of scalable quantum optical devices
Bulk AlInAs on InP(111) as a novel material system for pure single photon emission
In this letter, we report on quantum light emission from bulk AlInAs grown on InP(111) substrates. We observe indium rich clusters in the bulk Al0:48In0:52As (AlInAs), resulting in quantum dot-like energetic traps for charge carriers, which are confirmed via cross-sectional scanning tunnelling microscopy (XSTM) measurements and 6-band k•p simulations. We observe quantum dot (QD)-like emission signals, which appear as sharp lines in our photoluminescence spectra at near infrared wavelengths around 860 nm, and with linewidths as narrow as 50 meV. We demonstrate the capability of this new material system to act as an emitter of pure single photons as we extract g(2)-values as low as g(2)/cw (0) = 0:05+0:17/-0:05 for continuous wave (cw) excitation and g (2) pulsed, corr. = 0:24 ± 0:02 for pulsed excitation.PostprintPeer reviewe
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