38 research outputs found
Lipid Mediators and Human Leukemic Blasts
Get PDFSome of the most potent inflammatory mediators share a lipid origin. They regulate a wide spectrum of cellular processes including cell proliferation and apoptosis. However, the precise roles and ways (if any) in which these compounds impact the growth and apoptosis of leukemic blasts remain incompletely resolved. In spite of this, significant advances have been recently made. Here we briefly review the current knowledge about the production of lipid mediators (prostaglandins, leukotrienes, platelet-activating factor) by leukemic blasts, the enzymatic activities (phospholipase A2, cyclooxygenases, lipoxygenases) involved in their productions and their effects (through specific membrane bound receptors) on the growth, and apoptosis of leukemic blasts
Genes encoding multiple forms of phospholipase A(2) are expressed in immature forms of human leukemic blasts.
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The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
Full text linkCharacterisation of Genome-Wide PLZF/RARA Target Genes
Get PDFThe PLZF/RARA fusion protein generated by the t(11;17)(q23;q21) translocation in acute promyelocytic leukaemia (APL) is believed to act as an oncogenic transcriptional regulator recruiting epigenetic factors to genes important for its transforming potential. However, molecular mechanisms associated with PLZF/RARA-dependent leukaemogenesis still remain unclear
Identification of multiple immune escape mechanisms involved in Waldenström’s macroglobulinemia: a therapeutic perspective
No full textIdentification of multiple immune escape mechanisms involved in Waldenström’s macroglobulinemia emergence and transformation into diffuse large B-cell lymphoma
No full textMécanismes d’échappement immunitaire et Maladie de Waldenström : de l’identification aux perspectives thérapeutiques
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Identification des mécanismes d’échappement immunitaire impliqués dans le développement de la Maladie de Waldenström : Impact de l’Ibrutinib et nouvelles perspectives thérapeutiques
No full textEditorial: Mouse Models of B Cell Malignancies
No full text© 2021 Perez-Chacon, Vincent-Fabert and Zapata.B cell malignancies represent a vast group of different entities arising from the multiple differentiation stages of B cells. In humans, there is a large variety of B cell malignancies, most of which have counterparts in mice. Prognosis and treatment for these malignancies would be largely dependent on their type, stage and grade.GP-C and JMZ were supported by a grant from the Agencia Estatal de Investigacion (PID2019-110405RB-I00/AEI/10.13039/ 501100011033). CV-F was supported by the France Lymphome Espoir association of patients and the Ligue contre le cancer
