The Opium Wars, Opium Legalization, and Opium Consumption in China

The effect of drug prohibition on drug consumption is a critical issue in debates over drug policy. One episode that provides information on the consumption-reducing effect of drug prohibition is the Chinese legalization of opium in 1858. In this paper we examine the impact of China's opium legalization on the quantity and price of British opium exports from India to China during the 19th century. We find little evidence that legalization increased exports or decreased price. Thus, the evidence suggests China's opium prohibition had a minimal impact on opium consumpton.

Gemini GNIRS near-infrared spectroscopy of 50 quasars at z>~5.7

We report initial results from a large Gemini program to observe z>~5.7 quasars with GNIRS near-IR spectroscopy. Our sample includes 50 quasars with simultaneous ~0.85-2.5 micron spectra covering the rest-frame ultraviolet and major broad emission lines from Ly-alpha to MgII. We present spectral measurements for these quasars and compare to their lower-redshift counterparts at z=1.5-2.3. We find that when quasar luminosity is matched, there are no significant differences between the rest-UV spectra of z>~5.7 quasars and the low-z comparison sample. High-z quasars have similar continuum and emission line properties and occupy the same region in the black hole mass and luminosity space as the comparison sample, accreting at an average Eddington ratio of ~0.3. There is no evidence for super-Eddington accretion or hypermassive (>10^10 Msun) black holes within our sample. We find a mild excess of quasars with weak CIV lines relative to the control sample. Our results, corroborating earlier studies but with better statistics, demonstrate that these high-z quasars are already mature systems of accreting supermassive black holes operating with the same physical mechanisms as those at lower redshifts.Comment: replaced with the accepted version (ApJ); improved the fitting results and replaced all figures and tables (w/ minor changes); conclusions unchange

Probing the interstellar medium and star formation of the Most Luminous Quasar at z=6.3

We report new IRAM/PdBI, JCMT/SCUBA-2, and VLA observations of the ultraluminous quasar SDSSJ010013.02+280225.8 (hereafter, J0100+2802) at z=6.3, which hosts the most massive supermassive black hole (SMBH) of 1.24x10^10 Msun known at z>6. We detect the [C II] 158 $\mu$m fine structure line and molecular CO(6-5) line and continuum emission at 353 GHz, 260 GHz, and 3 GHz from this quasar. The CO(2-1) line and the underlying continuum at 32 GHz are also marginally detected. The [C II] and CO detections suggest active star formation and highly excited molecular gas in the quasar host galaxy. The redshift determined with the [C II] and CO lines shows a velocity offset of ~1000 km/s from that measured with the quasar Mg II line. The CO (2-1) line luminosity provides direct constraint on the molecular gas mass which is about (1.0+/-0.3)x10^10 Msun. We estimate the FIR luminosity to be (3.5+/-0.7)x10^12 Lsun, and the UV-to-FIR spectral energy distribution of J0100+2802 is consistent with the templates of the local optically luminous quasars. The derived [C II]-to-FIR luminosity ratio of J0100+2802 is 0.0010+/-0.0002, which is slightly higher than the values of the most FIR luminous quasars at z~6. We investigate the constraint on the host galaxy dynamical mass of J0100+2802 based on the [C II] line spectrum. It is likely that this ultraluminous quasar lies above the local SMBH-galaxy mass relationship, unless we are viewing the system at a small inclination angle.Comment: 19 pages, 4 figures, published by the Astrophysical Journal, minimal changes in acknowledgement to match the published versio

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training (MICT), triggers RyR1 protein oxidation and nitrosylation leading to calstabin1 dissociation in healthy human muscle and in in vitro SIT models (simulated SIT or S-SIT). This is accompanied by decreased sarcoplasmic reticulum Ca2+ content, increased levels of mitochondrial oxidative phosphorylation proteins, supercomplex formation and enhanced NADH-linked mitochondrial respiratory capacity. Mechanistically, (S-)SIT increases mitochondrial Ca2+ uptake in mouse myotubes and muscle fibres, and decreases pyruvate dehydrogenase phosphorylation in human muscle and mouse myotubes. Countering Ca2+ leak or preventing mitochondrial Ca2+ uptake blunts S-SIT-induced adaptations, a result supported by proteomic analyses. Here we show that triggering acute transient Ca2+ leak through RyR1 in healthy muscle may contribute to the multiple health promoting benefits of exercise

Bootstrapping the QCD soft anomalous dimension

SCOAP

Milliarcsecond Imaging of the Radio Emission from the Quasar with the Most Massive Black Hole at Reionization

We report Very Long Baseline Array (VLBA) observations of the 1.5 GHz radio continuum emission of the z = 6.326 quasar SDSS J010013.02+ 280225.8 (hereafter J0100+ 2802). J0100+ 2802 is by far the most optically luminous and is a radio-quiet quasar with the most massive black hole known at z > 6. The VLBA observations have a synthesized beam size of 12.10 mas x5.36 mas (FWHM), and detected the radio continuum emission from this object with a peak surface brightness of 64.6 +/- 9.0 mu Jy beam(-1) and a total flux density of 88 +/- 19 mu Jy. The position of the radio peak is consistent with that from SDSS in the optical and Chandra in the X-ray. The radio source is marginally resolved by the VLBA observations. A 2D Gaussian fit to the image constrains the source size to (7.1 +/- 3.5) mas x (3.1 +/- 1.7) mas. This corresponds to a physical scale of (40 +/- 20) pc x (18 +/- 10) pc. We estimate the intrinsic brightness temperature of the VLBA source to be T-B = (1.6 +/- 1.2) x 10(7) K. This is significantly higher than the maximum value in normal star-forming galaxies, indicating an active galactic nucleus (AGN) origin for the radio continuum emission. However, it is also significantly lower than the brightness temperatures found in highest-redshift radio-loud quasars. J0100+ 2802 provides a unique example for studying the radio activity in optically luminous and radio-quiet AGNs in the early universe. Further observations at multiple radio frequencies will accurately measure the spectral index and address the dominant radiation mechanism of the radio emission.VLBA project [16A-247]; National Science Foundation of China (NSFC) [11373008, 11533001]; Strategic Priority Research Program "The Emergence of Cosmological Structures" of the Chinese Academy of Sciences [XDB09000000]; National Key Basic Research Program of China [2014CB845700]; National Key Program for Science and Technology Research and Development [2016YFA0400703]; Thousand Youth Talents Program of China; NSFC [11443002, 11473004]; NSF [AST 11-07682, 15-15115]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]