Multiple Impact of Integrated Watershed Management in Low Rainfall Semi-Arid Region: A Case Study from Eastern Rajasthan, India

The agriculture in low rainfall areas of eastern Rajasthan, India is characterized by high risks from drought, degraded natural resources and pervasive poverty, food insecurity and malnutrition. In this region, water is the main limiting factor for upgrading rainfed agriculture. For such areas integrated watershed management is recognized as a potential approach for agriculture growth and rehabilitation of fragile and degraded lands. At Gokulpura-Goverdhanpura village in Bundi eastern Rajasthan, India an integrated watershed project was implemented using the holistic systems approach. This paper discusses the impacts of this watershed program on bio-physical, socio-economic, environmental and ecological parameters. Results indicate that due to watershed interventions the groundwater availability has substantially increased which brought changes in cropping patterns with high value crops. Significant increases in irrigated area, cropping intensity along with diversification of crops from traditional to commercial cash crops were recorded. The watershed program also significantly improved the socio-economic status of the watershed community. It has increased the income and reduced poverty of the people in the watershed. The watershed interventions generated good employment opportunities and significantly reduced the migration of both skilled and unskilled labor from the watershed village to urban areas. It has also improved the environmental quality and ecological status in the watershed. The watershed interventions increased the vegetative index or greenery, reduced runoff, soil loss, and land degradations and improved the bio-diversity in fragile ecosystems. Overall, the integrated watershed program at Gokulpura-Goverdhanpura provided resilience by ensuring continued and sustainable multiple outputs, besides soil and water conservation and other positive environmental effects

State-of-the-art in stock prediction techniques

ABSTRACT: Stock markets are affected by many uncertainties and interrelated economic and political factors at both local and global levels. The key to successful stock market forecasting is achieving best results with minimum required input data. To determine the set of relevant factors for making accurate predictions is a complicated task and so regular stock market analysis is very essential. More specifically, the stock market's movements are analyzed and predicted in order to retrieve knowledge that could guide investors on when to buy and sell. It will also help the investor to make money through his investment in the stock market. This paper surveys large number of resources from research papers, web-sources, company reports and other available sources

Rural Prosperity through Integrated Watershed Management:A Case Study of Gokulpura-Goverdhanpura in Eastern Rajasthan. Global Theme on Agroecosystems Report no.36

The agriculture in eastern Rajasthan is characterized by high risks from drought, degraded natural resources and pervasive poverty. At Gokulpura-Goverdhanpura village in Bundi Rajasthan,ICRISAT along with partners implemented integrated watershed project using holistic systems approach with integrated genetic and natural resource management (IGNRM) strategy. This report discusses the multi-faceted impact of this watershed program. It has been found that the science-led participatory watershed program at Gokulpura- Goverdhanpura had made positive impacts on natural resources, rural livelihoods and environment. The major impact of watershed interventions was seen in improving the surface and groundwater availability. Increased water availability resulted in increased cropping intensity and diversification to more remunerative land use systems involving livestock, horticultural and vegetable production. Overall, the watershed program has reduced land degradation, enhanced agricultural productivity and incomes, decreased poverty of rural poor, reduced labor migration and improved environment quality

Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response:An Observational Study Using Electronic Health Records

Background: Statin intolerance impacts approximately 10% of statin users, with side effects ranging from mild myalgia to extreme intolerance resulting in myopathy and rhabdomyolysis. Statin intolerance results in poor adherence to therapy and can impact statin efficacy. Many genetic variants are associated with statin intolerance. The effect of these variants on statin efficacy has not been systematically explored.Methods: Using longitudinal electronic health records and genetic biobank data from Tayside, Scotland, we examined the effect of seven genetic variants with previously reported associations with simvastatin or atorvastatin intolerance on the outcome of statin response. Statin response was measured by the reduction achieved when comparing pre- and post-statin non-high-density lipoprotein-cholesterol (non-HDL-C). Post-treatment statin response was limited to non-HDL-C measured within 6months of therapy initiation. Univariate and multivariable linear regression models were used to assess the main and adjusted effect of the variants on statin efficacy.Results: Around 9,401 statin users met study inclusion criteria, of whom 8,843 were first prescribed simvastatin or atorvastatin. The average difference in post-treatment compared to pre-treatment non-HDL-cholesterol was 1.45 (±1.04) mmol/L. In adjusted analyses, only two variants, one in the gene ATP-binding cassette transporter B1 (ABCB1; rs1045642), and one in leukocyte immunoglobulin like receptor B5 (LILRB5; rs12975366), were associated with statin efficacy. In ABCB1, homozygous carriers of the C allele at rs1045642 had 0.06mmol/L better absolute reduction in non-HDL-cholesterol than carriers of the T allele (95% CI: 0.01, 0.1). In LILRB5 (rs12975366), carriers of the C allele had 0.04mmol/L better absolute reduction compared to those homozygous for the T allele (95% CI: 0.004, 0.08). When combined into a two-variant risk score, individuals with both the rs1045642-CC genotype and the rs12975366-TC or CC genotype had a 0.11mmol/L greater absolute reduction in non-HDL-cholesterol compared to those with rs1045642-TC or TT genotype and the rs12975366-TT genotype (95% CI: 0.05, 0.16; p<0.001).Conclusion: We report two genetic variants for statin adverse drug reactions (ADRs) that are associated with statin efficacy. While the ABCB1 variant has been shown to have an association with statin pharmacokinetics, no similar evidence for LILRB5 has been reported. These findings highlight the value of genetic testing to deliver precision therapeutics to statin users

Enhanced productivity and income through balanced nutrition in Madhya Pradesh and Rajasthan Watersheds

Community watersheds technically supported by the consortium of institutions adopt holistic system's approach as against the compartmental approach of soil and water conservation. ICRISAT-led consortium used characterization of soil resources in the benchmark watersheds (Semli and Shyampura Watersheds, Dewas district and Madhusudangadh watershed, Guna district in Madhya Pradesh and Bundi Watershed, Bundi district in Rajasthan, India) as an entry point activity. Stratified sampling of fields on a toposequence in the watersheds revealed widespread deficiency of multiple nutrients particularly Zn (67-100%), B (72-100%) with an exception of Guna and S (72-100%) along with N and P, which could be limiting the yield potential in the watersheds. Farmers' participatory research trials with different crops showed tremendous yield advantages upto 79% over the farmers practice. The FPR trials also showed economic viability of amendment options with a net increased profit of Rs. 8190 ha-1 in case of wheat and Rs. 10740 with chickpea in M.P. watersheds. These FPR trials highlighted the urgency to provide right information about soil health to the farmers in time and empowering them to adopt balanced nutrient management strategies for increasing productivity and minimizing cost of inputs that are unnecessar

Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population

Background: Diabetic retinopathy (DR) is a major sight-threatening microvascular complication in individuals with diabetes. Systemic inflammation combined with oxidative stress is thought to capture most of the complexities involved in the pathology of diabetic retinopathy. A high level of neutrophil–lymphocyte ratio (NLR) is an indicator of abnormal immune system activity. Current estimates of the association of NLR with diabetes and its complications are almost entirely derived from cross-sectional studies, suggesting that the nature of the reported association may be more diagnostic than prognostic. Therefore, in the present study, we examined the utility of NLR as a biomarker to predict the incidence of DR in the Scottish population.Methods: The incidence of DR was defined as the time to the first diagnosis of R1 or above grade in the Scottish retinopathy grading scheme from type 2 diabetes diagnosis. The effect of NLR and its interactions were explored using a competing risks survival model adjusting for other risk factors and accounting for deaths. The Fine and Gray subdistribution hazard model (FGR) was used to predict the effect of NLR on the incidence of DR.Results: We analysed data from 23,531 individuals with complete covariate information. At 10 years, 8416 (35.8%) had developed DR and 2989 (12.7%) were lost to competing events (death) without developing DR and 12,126 individuals did not have DR. The median (interquartile range) level of NLR was 2.04 (1.5 to 2.7). The optimal NLR cut-off value to predict retinopathy incidence was 3.04. After accounting for competing risks at 10 years, the cumulative incidence of DR and deaths without DR were 50.7% and 21.9%, respectively. NLR was associated with incident DR in both Cause-specific hazard (CSH = 1.63; 95% CI: 1.28–2.07) and FGR models the subdistribution hazard (sHR = 2.24; 95% CI: 1.70–2.94). Both age and HbA 1c were found to modulate the association between NLR and the risk of DR.Conclusions: The current study suggests that NLR has a promising potential to predict DR incidence in the Scottish population, especially in individuals less than 65 years and in those with well-controlled glycaemic status.</p

Measuring Success for a Future Vision: Defining Impact in Science Gateways/Virtual Research Environments

Scholars worldwide leverage science gateways/VREs for a wide variety of research and education endeavors spanning diverse scientific fields. Evaluating the value of a given science gateway/VRE to its constituent community is critical in obtaining the financial and human resources necessary to sustain operations and increase adoption in the user community. In this paper, we feature a variety of exemplar science gateways/VREs and detail how they define impact in terms of e.g., their purpose, operation principles, and size of user base. Further, the exemplars recognize that their science gateways/VREs will continuously evolve with technological advancements and standards in cloud computing platforms, web service architectures, data management tools and cybersecurity. Correspondingly, we present a number of technology advances that could be incorporated in next-generation science gateways/VREs to enhance their scope and scale of their operations for greater success/impact. The exemplars are selected from owners of science gateways in the Science Gateways Community Institute (SGCI) clientele in the United States, and from the owners of VREs in the International Virtual Research Environment Interest Group (VRE-IG) of the Research Data Alliance. Thus, community-driven best practices and technology advances are compiled from diverse expert groups with an international perspective to envisage futuristic science gateway/VRE innovations

Cyclodextrin Complexes of Reduced Bromonoscapine in Guar Gum Microspheres Enhance Colonic Drug Delivery

Here, we report improved solubility and enhanced colonic delivery of reduced bromonoscapine (Red-Br-Nos), a cyclic ether brominated analogue of noscapine, upon encapsulation of its cyclodextrin (CD) complexes in bioresponsive guar gum microspheres (GGM). Phase−solubility analysis suggested that Red-Br-Nos complexed with β-CD and methyl-β-CD in a 1:1 stoichiometry, with a stability constant (Kc) of 2.29 × 103 M−1 and 4.27 × 103 M−1. Fourier transforms infrared spectroscopy indicated entrance of an O−CH2 or OCH3−C6H4−OCH3 moiety of Red-Br-Nos in the β-CD or methyl-β- CD cavity. Furthermore, the cage complex of Red-Br-Nos with β-CD and methyl-β-CD was validated by several spectral techniques. Rotating frame Overhauser enhancement spectroscopy revealed that the Ha proton of the OCH3−C6H4−OCH3 moiety was closer to the H5 proton of β-CD and the H3 proton of the methyl-β-CD cavity. The solubility of Red-Br-Nos in phosphate buffer saline (PBS, pH ∼ 7.4) was improved by ∼10.7-fold and ∼21.2-fold when mixed with β-CD and methyl-β-CD, respectively. This increase in solubility led to a favorable decline in the IC50 by ∼2-fold and ∼3-fold for Red-Br-Nos−β-CD-GGM and Red-Br-Nos−methyl-β-CD-GGM formulations respectively, compared to free Red-Br-Nos−β-CD and Red-Br-Nos−methyl-β-CD in human colon HT-29 cells. GGM-bearing drug complex formulations were found to be highly cytotoxic to the HT-29 cell line and further effective with simultaneous continuous release of Red-Br-Nos from microspheres. This is the first study to showing the preparation of drug-complex loaded GGMS for colon delivery of Red-Br-Nos that warrants preclinical assessment for the effective management of colon cancer