Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival “neuronal” subtype in which the majority of tumors lacked small cell or neuroendocrine histology. Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged to identify subsets with differential epithelial-mesenchymal transition status, carcinoma in situ scores, histologic features, and survival. Our analyses identified 5 expression subtypes that may stratify response to different treatments. A multiplatform analysis of 412 muscle-invasive bladder cancer patients provides insights into mutational profiles with prognostic value and establishes a framework associating distinct tumor subtypes with clinical options

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Application of bamboo fibre composite in structural strengthening

Fibre reinforced polymer (FRP) is the most commonly used for structural strengthening, however, it requires high energy consumption to manufacture and non-environmental friendly. Alternatively, natural fibres such as bamboo, which has a high tensile strength characteristics may be used. However, limited study on the use of bamboo fibre as external structural strengthening is available. This paper presents the application of bamboo fibre vinyl-ester composite plate (BFVCP) for the strengthening of reinforced concrete (RC) beams. In this study, fibre volume fraction ranging from 0% to 40% were considered. The effect of volume fraction on the flexural and tensile strength of the composite plate was evaluated through mechanical test. The structural behaviour of RC beams was tested to failure using a four-point bending. BFVCP were applied externally in the beam’s mid-span of the bottom soffit to study the structural strengthening in flexure. Results showed that the highest tensile strength of the specimen was obtained using the fibre volume fraction of 40%. Strengthening of RC beam using BFVCP successfully re-gained about 2% of the original beam structural capacity, when applied to the weakened beam in flexure along the tension zone. Strengthening by BFVCP has diverted the vertical cracks at the mid-span to the edge of the plate. Result from this study shows that BFVCP may be used for weakened beam external strengthening

Insecticidal and repellent properties of nine volatile constituents of essential oils against the American cockroach, Periplaneta americana (L.)

10.1002/(SICI)1096-9063(1998110)54:33.0.CO;2-CPesticide Science543261-268PSSC

Potentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients

10.1371/journal.pone.0111694PLoS ONE911e11169

Phase I pharmacokinetic study of chronomodulated dose-intensified combination of capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer

10.1007/s00280-012-1895-xCancer Chemotherapy and Pharmacology701141-150CCPH