Differentiable Display Photometric Stereo

Photometric stereo leverages variations in illumination conditions to reconstruct per-pixel surface normals. The concept of display photometric stereo, which employs a conventional monitor as an illumination source, has the potential to overcome limitations often encountered in bulky and difficult-to-use conventional setups. In this paper, we introduce Differentiable Display Photometric Stereo (DDPS), a method designed to achieve high-fidelity normal reconstruction using an off-the-shelf monitor and camera. DDPS addresses a critical yet often neglected challenge in photometric stereo: the optimization of display patterns for enhanced normal reconstruction. We present a differentiable framework that couples basis-illumination image formation with a photometric-stereo reconstruction method. This facilitates the learning of display patterns that leads to high-quality normal reconstruction through automatic differentiation. Addressing the synthetic-real domain gap inherent in end-to-end optimization, we propose the use of a real-world photometric-stereo training dataset composed of 3D-printed objects. Moreover, to reduce the ill-posed nature of photometric stereo, we exploit the linearly polarized light emitted from the monitor to optically separate diffuse and specular reflections in the captured images. We demonstrate that DDPS allows for learning display patterns optimized for a target configuration and is robust to initialization. We assess DDPS on 3D-printed objects with ground-truth normals and diverse real-world objects, validating that DDPS enables effective photometric-stereo reconstruction

Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimers disease

Abstract Background Dynamically altered microglia play an important role in the progression of Alzheimers disease (AD). Here, we found a close association of the metabolic reconfiguration of microglia with increased hippocampal glucose uptake on [18F]fluorodeoxyglucose (FDG) PET. Methods We used an AD animal model, 5xFAD, to analyze hippocampal glucose metabolism using both animal FDG PET and ex vivo FDG uptake test. Cells of the hippocampus were isolated to perform single-cell RNA-sequencing (scRNA-seq). The molecular features of cells associated with glucose metabolism were analyzed at a single-cell level. In order to apply our findings to human brain imaging study, brain FDG PET data obtained from the Alzheimers Disease Neuroimaging Initiative were analyzed. FDG uptake in the hippocampus was compared according to the diagnosis, AD, mild cognitive impairment, and controls. The correlation analysis between hippocampal FDG uptake and soluble TREM2 in cerebrospinal fluid was performed. Results In the animal study, 8- and 12-month-old 5xFAD mice showed higher FDG uptake in the hippocampus than wild-type mice. Cellular FDG uptake tests showed that FDG activity in hippocampal microglia was increased in the AD model, while FDG activity in non-microglial cells of the hippocampus was not different between the AD model and wild-type. scRNA-seq data showed that changes in glucose metabolism signatures including glucose transporters, glycolysis and oxidative phosphorylation, mainly occurred in microglia. A subset of microglia with higher glucose transporters with defective glycolysis and oxidative phosphorylation was increased according to disease progression. In the human imaging study, we found a positive association between soluble TREM2 and hippocampal FDG uptake. FDG uptake in the hippocampus at the baseline scan predicted mild cognitive impairment conversion to AD. Conclusions We identified the reconfiguration of microglial glucose metabolism in the hippocampus of AD, which could be evaluated by FDG PET as a feasible surrogate imaging biomarker for microglia-mediated inflammation

Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning

Full-Duplex MU-MIMO Systems with Coarse Quantization: How Many Bits Do We Need?

This paper investigates full-duplex (FD) multi-user multiple-input multiple-output (MU-MIMO) system design with coarse quantization. We first analyze the impact of self-interference (SI) on quantization in FD single-input single-output systems. The analysis elucidates that the minimum required number of analog-to-digital converter (ADC) bits is logarithmically proportional to the ratio of total received power to the received power of desired signals. Motivated by this, we design a FD MIMO beamforming method that effectively manages the SI. Dividing a spectral efficiency maximization beamforming problem into two sub-problems for alternating optimization, we address the first by optimizing the precoder: obtaining a generalized eigenvalue problem from the first-order optimality condition, where the principal eigenvector is the optimal stationary solution, and adopting a power iteration method to identify this eigenvector. Subsequently, a quantization-aware minimum mean square error combiner is computed for the derived precoder. Through numerical studies, we observe that the proposed beamformer reduces the minimum required number of ADC bits for achieving higher spectral efficiency than that of half-duplex (HD) systems, compared to FD benchmarks. The overall analysis shows that, unlike with quantized HD systems, more than 6 bits are required for the ADC to fully realize the potential of the quantized FD system

A selective fluorescent probe for cysteine and its imaging in live cells

A probe for the detection of cysteine over homocysteine based on 2-(2'-hydroxyphenyl) benzothiazole (HBT) was prepared and used in confocal microscopy experiments. The probe was designed to block excited state intramolecular proton transfer (ESIPT). When bromopropionyl group protection is removed, HBT is recovered via nucleophilic substitution and intramolecular cyclization. The probe was found to have a detection limit of 2.8 mu M and exhibits a similar to 20-fold increase. The probe showed cell membrane permeability and efficacy in living Hep3B cells © The Royal Society of Chemistry 2014191

A 3-D Camera With Adaptable Background Light Suppression Using Pixel-Binning and Super-Resolution

This paper presents a CMOS time-of-flight (TOF) 3-D camera employing a column-level background light (BGL) suppression scheme for high-resolution outdoor imaging. The use of the column-level approach minimizes a pixel size for high-density pixel arrays. Pixel-binning and super-resolution can be adaptably applied for an optimal BGL suppression at given spatiotemporal resolutions. A prototype sensor has been fabricated by using 0.11 ??m CMOS processes. The sensor achieved a fill factor of 24% in a pixel pitch of 5.9 ??m which is the smallest among all the reported TOF cameras up to date. Measurement results showed the temporal noise of 1.47 cm-rms with a 100 ms integration time at a demodulation frequency of 12.5 MHz using a white target at 1 m distance. The non-linearity was measured as 1% over the range of 0.75 m ~ 4 m. The BGL suppression over 100 klx was achieved from indoor and outdoor experiments, while the BGL-induced offset was maintained less than 2.6 cm under 0 ~ 100 klx.close0

A 5.9??m-pixel 2D/3D Image Sensor with Background Suppression Over 100klx

A 2D/3D image sensor with reconfigurable pixel array and column-level background suppression scheme is presented for high resolution outdoor imaging. The proposed pixel array employs pixel binning and superresolution techniques for adaptable resolution. The sensor achieved a 5.9??m pixel and was able to capture full resolution outdoor depth images under daylight over 100klx