Cyclic fatigue resistance tests of Nickel-Titanium rotary files using simulated canal and weight loading conditions

published_or_final_versio

Cosmic Ray Acceleration at Relativistic Shock Waves with a "Realistic" Magnetic Field Structure

The process of cosmic ray first-order Fermi acceleration at relativistic shock waves is studied with the method of Monte Carlo simulations. The simulations are based on numerical integration of particle equations of motion in a turbulent magnetic field near the shock. In comparison to earlier studies, a few "realistic" features of the magnetic field structure are included. The upstream field consists of a mean field component inclined at some angle to the shock normal with finite-amplitude sinusoidal perturbations imposed upon it. The perturbations are assumed to be static in the local plasma rest frame. Their flat or Kolmogorov spectra are constructed with randomly drawn wave vectors from a wide range $(k_{min}, k_{max})$. The downstream field structure is derived from the upstream one as compressed at the shock. We present particle spectra and angular distributions obtained at mildly relativistic sub- and superluminal shocks and also parallel shocks. We show that particle spectra diverge from a simple power-law, the exact shape of the spectrum depends on both the amplitude of the magnetic field perturbations and the wave power spectrum. Features such as spectrum hardening before the cut-off at oblique subluminal shocks and formation of power-law tails at superluminal ones are presented and discussed. At parallel shocks, the presence of finite-amplitude magnetic field perturbations leads to the formation of locally oblique field configurations at the shock and the respective magnetic field compressions. This results in the modification of the particle acceleration process, introducing some features present in oblique shocks, e.g., particle reflections from the shock. We demonstrate for parallel shocks a (nonmonotonic) variation of the particle spectral index with the turbulence amplitude.Comment: revised version (37 pages, 13 figures

Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9

Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons. Here, we show that CjCas9 derived from Campylobacter jejuni can be used as a gene editing tool to correct an out-of-frame Dmd exon in Dmd knockout mice. Herein, we used Cas9 derived from S. pyogenes to generate Dmd knockout (KO) mice with a frameshift mutation in Dmd gene. Then, we expressed CjCas9, its single-guide RNA, and the eGFP gene in the tibialis anterior muscle of the Dmd KO mice using an all-in-one adeno-associated virus (AAV) vector. CjCas9 cleaved the target site in the Dmd gene efficiently in vivo and induced small insertions or deletions at the target site. This treatment resulted in conversion of the disrupted Dmd reading frame from out-of-frame to in-frame, leading to the expression of dystrophin in the sarcolemma. Importantly, muscle strength was enhanced in the CjCas9-treated muscles, without off-target mutations, indicating high efficiency and specificity of CjCas9. This work suggests that in vivo DMD frame correction, mediated by CjCas9 has great potential for the treatment of DMD and other neuromuscular diseases

Possible evidence of non-Fermi liquid behavior from quasi-one-dimensional indium nanowires

We report possible evidence of non-Fermi liquid (NFL) observed at room temperature from the quasi one-dimensional (1D) indium (In) nanowires self-assembled on Si(111)-7$\times$7 surface. Using high-resolution electron-energy-loss spectroscopy, we have measured energy and width dispersions of a low energy intrasubband plasmon excitation in the In nanowires. We observe the energy-momentum dispersion $\omega$(q) in the low q limit exactly as predicted by both NFL theory and the random-phase-approximation. The unusual non-analytic width dispersion $\zeta(q) \sim q^{\alpha}$ measured with an exponent ${\alpha}$=1.40$\pm$0.24, however, is understood only by the NFL theory. Such an abnormal width dispersion of low energy excitations may probe the NFL feature of a non-ideal 1D interacting electron system despite the significantly suppressed spin-charge separation ($\leq$40 meV).Comment: 11 pages and 4 figure

Conserved current for the Cotton tensor, black hole entropy and equivariant Pontryagin forms

The Chern-Simons lagrangian density in the space of metrics of a 3-dimensional manifold M is not invariant under the action of diffeomorphisms on M. However, its Euler-Lagrange operator can be identified with the Cotton tensor, which is invariant under diffeomorphims. As the lagrangian is not invariant, Noether Theorem cannot be applied to obtain conserved currents. We show that it is possible to obtain an equivariant conserved current for the Cotton tensor by using the first equivariant Pontryagin form on the bundle of metrics. Finally we define a hamiltonian current which gives the contribution of the Chern-Simons term to the black hole entropy, energy and angular momentum.Comment: 13 page

STATIC FOUR-DIMENSIONAL ABELIAN BLACK HOLES IN KALUZA-KLEIN THEORY

Static, four-dimensional (4-d) black holes (BH's) in ($4+n$)-d Kaluza-Klein (KK) theory with Abelian isometry and diagonal internal metric have at most one electric ($Q$) and one magnetic ($P$) charges, which can either come from the same $U(1)$-gauge field (corresponding to BH's in effective 5-d KK theory) or from different ones (corresponding to BH's with $U(1)_M\times U(1)_E$ isometry of an effective 6-d KK theory). In the latter case, explicit non-extreme solutions have the global space-time of Schwarzschild BH's, finite temperature, and non-zero entropy. In the extreme (supersymmetric) limit the singularity becomes null, the temperature saturates the upper bound $T_H=1/4\pi\sqrt{|QP|}$, and entropy is zero. A class of KK BH's with constrained charge configurations, exhibiting a continuous electric-magnetic duality, are generated by global $SO(n)$ transformations on the above classes of the solutions.Comment: 11 pages, 2 Postscript figures. uses RevTeX and psfig.sty (for figs) paper and figs also at ftp://dept.physics.upenn.edu/pub/Cvetic/UPR-645-

Depletion of density of states near Fermi energy induced by disorder and electron correlation in alloys

We have performed high resolution photoemission study of substitutionally disordered alloys Cu-Pt, Cu-Pd, Cu-Ni, and Pd-Pt. The ratios between alloy spectra and pure metal spectra are found to have dips at the Fermi level when the residual resistivity is high and when rather strong repulsive electron-electron interaction is expected. This is in accordance with Altshuler and Aronov's model which predicts depletion of density of states at the Fermi level when both disorder and electron correlation are present.Comment: 1 tex file and 4 ps file

Joint Blind Motion Deblurring and Depth Estimation of Light Field

Removing camera motion blur from a single light field is a challenging task since it is highly ill-posed inverse problem. The problem becomes even worse when blur kernel varies spatially due to scene depth variation and high-order camera motion. In this paper, we propose a novel algorithm to estimate all blur model variables jointly, including latent sub-aperture image, camera motion, and scene depth from the blurred 4D light field. Exploiting multi-view nature of a light field relieves the inverse property of the optimization by utilizing strong depth cues and multi-view blur observation. The proposed joint estimation achieves high quality light field deblurring and depth estimation simultaneously under arbitrary 6-DOF camera motion and unconstrained scene depth. Intensive experiment on real and synthetic blurred light field confirms that the proposed algorithm outperforms the state-of-the-art light field deblurring and depth estimation methods

On-Demand Power Source for Medical Electronic Implants: Acousto-Mechanical Vibrations from Human Vocal Folds

For use in vibration-driven power generation, we have quantitatively characterized the acousto-mechanical vibrations that propagate from the human vocal folds through the neck and head along the skeletal frames. We have used five MEMS accelerometers to characterize the acousto-mechanical vibrations present in various situations. The acousto-mechanical vibrations excite vibration-driven energy harvesters at their resonance frequencies between 90-300 Hz and generate up to 0.15 mW/cm^3 on demand