Commuting and wellbeing in London: The roles of commute mode and local public transport connectivity.

PublishedJournal ArticleOBJECTIVES: To explore the relationships between commute mode, neighbourhood public transport connectivity and subjective wellbeing. METHOD: The study used data on 3630 commuters in London from wave two of Understanding Society (2010/11). Multivariate linear regressions were used to investigate how commute mode and neighbourhood public transport connectivity were associated with subjective wellbeing for all London commuters and for public transport commuters only. Subjective wellbeing was operationalized in terms of both a positive expression (life satisfaction measured by a global single-item question) and a more negative expression (mental distress measured by the General Health Questionnaire). Logistic regression was also used to explore the predictors of public transport over non-public transport commutes. RESULTS: After accounting for potentially-confounding area-level and individual-level socioeconomic and commute-related variables, only walking commutes (but not other modes) were associated with significantly higher life satisfaction than car use but not with lower mental distress, compared to driving. While better public transport connectivity was associated with significantly lower mental distress in general, train users with better connectivity had higher levels of mental distress. Moreover, connectivity was unrelated to likelihood of using public transport for commuting. Instead, public transport commutes were more likely amongst younger commuters who made longer distance commutes and had comparatively fewer children and cars within the household. CONCLUSION: The findings highlight the heterogeneity of relationships between commute mode, public transport connectivity and subjective wellbeing and have implications for intervention strategies and policies designed to promote commuting behaviour change.This work was undertaken as part of the first author's PhD funded by a Shell Global Solutions (UK) award to CA and supervised by CA, MW and SS. CA is partially funded by UK National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care of the South West Peninsula PenCLAHRC. MW is partially funded by NIHR Health Protection Research Unit in Environmental Change and Health at the London School of Hygiene and Tropical Medicine in partnership with Public Health England (PHE), and in collaboration with the University of Exeter, University College London, and the Met Office. The views expressed are those of the authors and not necessarily those of Shell Global Solutions (UK), the NHS or the NIHR, the Department of Health or PHE. The authorship order reflects relative contribution

HyPoradise: An Open Baseline for Generative Speech Recognition with Large Language Models

Advancements in deep neural networks have allowed automatic speech recognition (ASR) systems to attain human parity on several publicly available clean speech datasets. However, even state-of-the-art ASR systems experience performance degradation when confronted with adverse conditions, as a well-trained acoustic model is sensitive to variations in the speech domain, e.g., background noise. Intuitively, humans address this issue by relying on their linguistic knowledge: the meaning of ambiguous spoken terms is usually inferred from contextual cues thereby reducing the dependency on the auditory system. Inspired by this observation, we introduce the first open-source benchmark to utilize external large language models (LLMs) for ASR error correction, where N-best decoding hypotheses provide informative elements for true transcription prediction. This approach is a paradigm shift from the traditional language model rescoring strategy that can only select one candidate hypothesis as the output transcription. The proposed benchmark contains a novel dataset, “HyPoradise” (HP), encompassing more than 334, 000 pairs of N-best hypotheses and corresponding accurate transcriptions across prevalent speech domains. Given this dataset, we examine three types of error correction techniques based on LLMs with varying amounts of labeled hypotheses-transcription pairs, which gains a significant word error rate (WER) reduction. Experimental evidence demonstrates the proposed technique achieves a breakthrough by surpassing the upper bound of traditional re-ranking based methods. More surprisingly, LLM with reasonable prompt and its generative capability can even correct those tokens that are missing in N-best list. We make our results publicly accessible for reproducible pipelines with released pre-trained models, thus providing a new evaluation paradigm for ASR error correction with LLMs

Compartment Syndrome following Intramedullary Nail Fixation in Closed Tibial Shaft Fractures

Introduction: Compartment syndrome complicating intramedullary nailing of closed tibia fractures has been described as early as the 1980s, but currently remains less described in literature compared to compartment syndrome directly following trauma. This study aims to review this potentially disabling complication and highlight the importance of timely diagnosis and management of compartment syndrome following fracture fixation, not just after fracture itself, via a review of three cases. Material and methods: A retrospective study of a series of three cases was conducted. The type of fracture, wait time to fixation, surgery duration, reaming, size of nail implant used, tourniquet time, and surgical technique were recorded. Time to diagnosis of compartment syndrome, compartment pressure if available, extent of muscle necrosis, reconstructive procedures performed, and post-operative complications were analysed. Results: The three cases following high-energy trauma from road traffic accidents presented from January to May 2010. Compartment syndrome was diagnosed clinically for all cases, between one to six days post-operatively and supported by elevated compartment pressure measurements in two of the three cases. Conclusion: This study advocates thorough clinical monitoring and maintaining strong clinical suspicion of compartment syndrome in patients even after intramedullary nail fixation of tibial shaft fractures to achieve timely limb- salvaging intervention. While intercompartmental pressure can be used to aid in diagnosis, we do not advise using it in isolation to diagnose compartment syndrome. Tendon transfer improves functional mobility and provides a good result in patients with severe muscle damage, while skin grafting sufficient in patients with minimal muscle damag

Стимулирование инновационной активности персонала компании НГК

Объектом исследования выступает публичное акционерное общество "Газпром" и его дочернее общество с ограниченной ответственность "Газпром трансгаз Томск". Актуальность объясняется тем, что в настоящее время остаются открытыми вопросы привлечения ненаучного персонала предприятий нефтегазового комплекса к участию в инновационной деятельности. Целью работы является разработка способов стимулирования персонала предприятия нефтегазового комплекса к проявлению инновационной и рационализаторской активности. В исследовании проводился анализ применяемых способов мотивации и поощрения инновационных сотрудников предприятия нефтегазового комплекса. При проведении анализа выявляются ключевые проблемы стимулирования и предлагаются возможные решения.The object of the study is PJSC "Gazprom" and OOO "Gazprom transgaz Tomsk". The relevance is explained by the fact that at present the issues of attracting non-scientific personnel of oil and gas enterprises to participate in innovation remain open. The aim of the work is to develop ways to stimulate the personnel of the oil and gas complex to participate in innovation and rationalization activities. The study analyzed the methods used to motivate and encourage innovative employees of the oil and gas industry. The analysis identifies key incentive problems and suggests possible solutions

Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia

FMS-like tyrosine kinase 3 (FLT3) is the most commonly mutated gene found in acute myeloid leukemia (AML) patients and its activating mutations have been proven to be a negative prognostic marker for clinical outcome. Pacritinib (SB1518) is a tyrosine kinase inhibitor (TKI) with equipotent activity against FLT3 (IC50=22 n) and Janus kinase 2 (JAK2, IC50=23 n). Pacritinib inhibits FLT3 phosphorylation and downstream STAT, MAPK and PI3 K signaling in FLT3-internal-tandem duplication (ITD), FLT3-wt cells and primary AML blast cells. Oral administration of pacritinib in murine models of FLT3-ITD-driven AML led to significant inhibition of primary tumor growth and lung metastasis. Upregulation of JAK2 in FLT3-TKI-resistant AML cells was identified as a potential mechanism of resistance to selective FLT3 inhibition. This resistance could be overcome by the combined FLT3 and JAK2 activities of pacritinib in this cellular model. Our findings provide a rationale for the clinical evaluation of pacritinib in AML including patients resistant to FLT3-TKI therapy

Generalized Weyl solutions in d=5 Einstein-Gauss-Bonnet theory: the static black ring

We argue that the Weyl coordinates and the rod-structure employed to construct static axisymmetric solutions in higher dimensional Einstein gravity can be generalized to the Einstein-Gauss-Bonnet theory. As a concrete application of the general formalism, we present numerical evidence for the existence of static black ring solutions in Einstein-Gauss-Bonnet theory in five spacetime dimensions. They approach asymptotically the Minkowski background and are supported against collapse by a conical singularity in the form of a disk. An interesting feature of these solutions is that the Gauss-Bonnet term reduces the conical excess of the static black rings. Analogous to the Einstein-Gauss-Bonnet black strings, for a given mass the static black rings exist up to a maximal value of the Gauss-Bonnet coupling constant $\alpha'$. Moreover, in the limit of large ring radius, the suitably rescaled black ring maximal value of $\alpha'$ and the black string maximal value of $\alpha'$ agree.Comment: 43 pages, 14 figure