Predicting rare events in chemical reactions: application to skin cell proliferation

In a well-stirred system undergoing chemical reactions, fluctuations in the reaction propensities are approximately captured by the corresponding chemical Langevin equation. Within this context, we discuss in this work how the Kramers escape theory can be used to predict rare events in chemical reactions. As an example, we apply our approach to a recently proposed model on cell proliferation with relevance to skin cancer [P.B. Warren, Phys. Rev. E {\bf 80}, 030903 (2009)]. In particular, we provide an analytical explanation for the form of the exponential exponent observed in the onset rate of uncontrolled cell proliferation.Comment: New materials and references added. To appear in Physical Review

Probing neutrino mass hierarchies and ϕ13\phi_{13} with supernova neutrinos

We investigate the feasibility of probing the neutrino mass hierarchy and the mixing angle $\phi_{13}$ with the neutrino burst from a future supernova. An inverse power-law density $\rho \sim r^{n}$ with varying $n$ is adopted in the analysis as the density profile of a typical core-collapse supernova. The survival probabilities of $\nu_{e}$ and $\bar{\nu}_{e}$ are shown to reduce to two-dimensional functions of $n$ and $\phi_{13}$. It is found that in the $n-\sin^{2} \phi_{13}$ parameter space, the 3D plots of the probability functions exhibit highly non-trivial structures that are sensitive to the mass hierarchy, the mixing angle $\phi_{13}$, and the value of $n$. The conditions that lead to observable differences in the 3D plots are established. With the uncertainty of $n$ considered, a qualitative analysis of the Earth matter effect is also included.Comment: 16 pages, 3 figures. Ref [11] added, and some typos correcte

Quenched chiral logarithms in lattice QCD with exact chiral symmetry

We examine quenched chiral logarithms in lattice QCD with overlap Dirac quark. For 100 gauge configurations generated with the Wilson gauge action at $\beta = 5.8$ on the $8^3 \times 24$ lattice, we compute quenched quark propagators for 12 bare quark masses. The pion decay constant is extracted from the pion propagator, and from which the lattice spacing is determined to be 0.147 fm. The presence of quenched chiral logarithm in the pion mass is confirmed, and its coefficient is determined to be $\delta = 0.203 \pm 0.014$, in agreement with the theoretical estimate in quenched chiral perturbation theory. Further, we obtain the topological susceptibility of these 100 gauge configurations by measuring the index of the overlap Dirac operator. Using a formula due to exact chiral symmetry, we obtain the $\eta'$ mass in quenched chiral perturbation theory, $m_{\eta'} = (901 \pm 64)$ Mev, and an estimate of $\delta = 0.197 \pm 0.027$, which is in good agreement with that determined from the pion mass.Comment: 24 pages, 6 EPS figures; v2: some clarifications added, to appear in Physical Review

Demonstration of the asymmetric lateral Casimir force between corrugated surfaces in the nonadditive regime

The measurement of the lateral Casimir force between two aligned sinusoidally corrugated Au-coated surfaces has been performed in the nonadditive regime. The use of deeper corrugations also allowed to demonstrate an asymmetry in the phase dependences of the lateral Casimir force, as predicted earlier. The measurement data are found to be in excellent agreement with the exact theoretical results computed at T=300 K including effect of real material properties. The deviations between the exact theory and the proximity force approximation are quantified. The obtained results are topical for applications in nanomachines.Comment: 9 pages, 3 figure

The prevalence of insomnia in the general population in China: A meta-analysis

This is the first meta-analysis of the pooled prevalence of insomnia in the general population of China. A systematic literature search was conducted via the following databases: PubMed, PsycINFO, EMBASE and Chinese databases (China National Knowledge Interne (CNKI), WanFang Data and SinoMed). Statistical analyses were performed using the Comprehensive Meta-Analysis program. A total of 17 studies with 115,988 participants met the inclusion criteria for the analysis. The pooled prevalence of insomnia in China was 15.0% (95% Confidence interval [CI]: 12.1%-18.5%). No significant difference was found in the prevalence between genders or across time period. The pooled prevalence of insomnia in population with a mean age of 43.7 years and older (11.6%; 95% CI: 7.5%-17.6%) was significantly lower than in those with a mean age younger than 43.7 years (20.4%; 95% CI: 14.2%-28.2%). The prevalence of insomnia was significantly affected by the type of assessment tools (Q = 14.1, P = 0.001). The general population prevalence of insomnia in China is lower than those reported in Western countries but similar to those in Asian countries. Younger Chinese adults appear to suffer from more insomnia than older adults

The perimeter of large planar Voronoi cells: a double-stranded random walk

Let $p\_n$ be the probability for a planar Poisson-Voronoi cell to have exactly $n$ sides. We construct the asymptotic expansion of $\log p\_n$ up to terms that vanish as $n\to\infty$. We show that {\it two independent biased random walks} executed by the polar angle determine the trajectory of the cell perimeter. We find the limit distribution of (i) the angle between two successive vertex vectors, and (ii) the one between two successive perimeter segments. We obtain the probability law for the perimeter's long wavelength deviations from circularity. We prove Lewis' law and show that it has coefficient 1/4.Comment: Slightly extended version; journal reference adde

Hot Topics in Ultra-Peripheral Collisions

Ultra-peripheral collisions of relativistic heavy ions involve long-ranged electromagnetic interactions at impact parameters too large for hadronic interactions to occur. The nuclear charges are large; with the coherent enhancement, the cross sections are also large. Many types of photonuclear and purely electromagnetic interactions are possible. We present here an introduction to ultra-peripheral collisions, and present four of the most compelling physics topics. This note developed from a discussion at a workshop on ``Electromagnetic Probes of Fundamental Physics,'' in Erice, Italy, Oct. 16-21, 2001.Comment: 7 pages, with 3 figures. This developed from a discussion at the workshop on "Electromagnetic Probes of Fundamental Physics," Oct. 16-21, Erice, Ital

Grand unification in the minimal left-right symmetric extension of the standard model

The simplest minimal left-right symmetric extension of the standard model is studied in the high energy limit, and some consequences of the grand unification hypothesis are explored assuming that the parity breaking scale is the only relevant energy between the electro-weak scale and the unification point. While the model is shown to be compatible with the observed neutrino phenomenology, the parity breaking scale and the heavy boson masses are predicted to be above 10^7 TeV, quite far from the reach of nowadays experiments. Below that scale only an almost sterile right handed neutrino is allowed with a mass M \approx 100 TeV