The analysis and modeling of the feedback process of the labor market: a dynamic model on Portugal’s national economy

The present paper proposes a system dynamics approach to the feedback process of the labor market taking place at macroeconomic level. The model was constructed on Keynesian theory introducing into the model adjustment by quantity and the wage was modeled as an endogenous state variable. The objective of studying the functioning of the presented feedback process is that of understanding its role and effect in the real economy cybernetic system in order to make it a functional part of the system of models that capture the national economy as a whole to be used in macroeconomic governance. The analysis and simulations of the model were done on Portugal’s national accounts between 2005 and 2011 and the model is able to produce the behavior in time of the state variables wage and unemployed persons close to historical data.info:eu-repo/semantics/publishedVersio

Interest-based RDF Update Propagation

Many LOD datasets, such as DBpedia and LinkedGeoData, are voluminous and process large amounts of requests from diverse applications. Many data products and services rely on full or partial local LOD replications to ensure faster querying and processing. While such replicas enhance the flexibility of information sharing and integration infrastructures, they also introduce data duplication with all the associated undesirable consequences. Given the evolving nature of the original and authoritative datasets, to ensure consistent and up-to-date replicas frequent replacements are required at a great cost. In this paper, we introduce an approach for interest-based RDF update propagation, which propagates only interesting parts of updates from the source to the target dataset. Effectively, this enables remote applications to `subscribe' to relevant datasets and consistently reflect the necessary changes locally without the need to frequently replace the entire dataset (or a relevant subset). Our approach is based on a formal definition for graph-pattern-based interest expressions that is used to filter interesting parts of updates from the source. We implement the approach in the iRap framework and perform a comprehensive evaluation based on DBpedia Live updates, to confirm the validity and value of our approach.Comment: 16 pages, Keywords: Change Propagation, Dataset Dynamics, Linked Data, Replicatio

Phase Diagram of Multilayer Magnetic Structures

Multilayer "ferromagnet-layered antiferromagnet" (Fe/Cr) structures frustrated due to the roughness of layer interfaces are studied by numerical modeling methods. The "thickness-roughness" phase diagrams for the case of thin ferromagnetic film on the surface of bulk antiferromagnet and for two ferromagnetic layers separated by an antiferromagnetic interlayer are obtained and the order parameter distributions for all phases are found. The phase transitions nature in such systems is considered. The range of applicability for the "magnetic proximity model" proposed by Slonczewski is evaluated.Comment: 8 pages, 8 figure

Time-Sensitive User Profile for Optimizing Search Personlization

International audienceThanks to social Web services, Web search engines have the opportunity to afford personalized search results that better fit the user’s information needs and interests. To achieve this goal, many personalized search approaches explore user’s social Web interactions to extract his preferences and interests, and use them to model his profile. In our approach, the user profile is implicitly represented as a vector of weighted terms which correspond to the user’s interests extracted from his online social activities. As the user interests may change over time, we propose to weight profiles terms not only according to the content of these activities but also by considering the freshness. More precisely, the weights are adjusted with a temporal feature. In order to evaluate our approach, we model the user profile according to data collected from Twitter. Then, we rerank initial search results accurately to the user profile. Moreover, we proved the significance of adding a temporal feature by comparing our method with baselines models that does not consider the user profile dynamics

Prolate spheroidal hematite particles equatorially belt with drug-carrying layered double hydroxide disks: Ring Nebula-like nanocomposites

A new nanocomposite architecture is reported which combines prolate spheroidal hematite nanoparticles with drug-carrying layered double hydroxide [LDH] disks in a single structure. Spindle-shaped hematite nanoparticles with average length of 225 nm and width of 75 nm were obtained by thermal decomposition of hydrothermally synthesized hematite. The particles were first coated with Mg-Al-NO3-LDH shell and then subjected to anion exchange with salicylate ions. The resulting bio-nanohybrid displayed a close structural resemblance to that of the Ring Nebula. Scanning electron microscope and transmission electron microscopy images showed that the LDH disks are stacked around the equatorial part of the ellipsoid extending along the main axis. This geometry possesses great structural tunability as the composition of the LDH and the nature of the interlayer region can be tailored and lead to novel applications in areas ranging from functional materials to medicine by encapsulating various guest molecules

Genetic and phenotypic characterization of NKX6‐2‐related spastic ataxia and hypomyelination

Background and purpose Hypomyelinating leukodystrophies are a heterogeneous group of genetic disorders with a wide spectrum of phenotypes and a high rate of genetically unsolved cases. Bi‐allelic mutations in NKX6‐2 were recently linked to spastic ataxia 8 with hypomyelinating leukodystrophy. Methods Using a combination of homozygosity mapping, exome sequencing, and detailed clinical and neuroimaging assessment a series of new NKX6‐2 mutations in a multicentre setting is described. Then, all reported NKX6‐2 mutations and those identified in this study were combined and an in‐depth analysis of NKX6‐2‐related disease spectrum was provided. Results Eleven new cases from eight families of different ethnic backgrounds carrying compound heterozygous and homozygous pathogenic variants in NKX6‐2 were identified, evidencing a high NKX6‐2 mutation burden in the hypomyelinating leukodystrophy disease spectrum. Our data reveal a phenotype spectrum with neonatal onset, global psychomotor delay and worse prognosis at the severe end and a childhood onset with mainly motor phenotype at the milder end. The phenotypic and neuroimaging expression in NKX6‐2 is described and it is shown that phenotypes with epilepsy in the absence of overt hypomyelination and diffuse hypomyelination without seizures can occur. Conclusions NKX6‐2 mutations should be considered in patients with autosomal recessive, very early onset of nystagmus, cerebellar ataxia with hypotonia that rapidly progresses to spasticity, particularly when associated with neuroimaging signs of hypomyelination. Therefore, it is recommended that NXK6‐2 should be included in hypomyelinating leukodystrophy and spastic ataxia diagnostic panels

Fibrillization of Human Tau Is Accelerated by Exposure to Lead via Interaction with His-330 and His-362

and its mutants at physiological pH. interaction with His-330 and His-362, with sub-micromolar affinity. in the pathogenesis of Alzheimer disease and provide critical insights into the mechanism of lead toxicity