Measuring the Relative Efficiency of IC Design Firms: A Directional Distance Functions and Meta-Frontier Approach

An alternative approach for evaluating the efficiency of integrated circuit (IC) design firms is presented in this paper. We took into account the differences between technology groups, containing one or more design firms, and input and output factors to prevent influences of scale (e.g., firm size). Specifically, we employed a directional distance function approach to data envelopment analysis in order to evaluate inefficiency scores and differences among groups based on input and output factors. We found the efficiency of Taiwan’s IC design firms to be dependent not only on firm size but also on R&D expenditure and patent revenue. Our findings suggest that these factors significantly influenced the technical efficiency of Taiwan IC design. Furthermore, by focusing on technology gaps, we offer some suggestions for the different groups based on group-frontier and meta-frontier analyses. Finally, using the results of these analyses, we extended the global results of this study, presenting ways to further improve their efficiency

IT/IS as the Secret Scroll of Kung Fu: A Functionalist Explanation of A Technical Structure for Information Systems Design

A company encounters many negative social consequences and persistent problems when it adopts a specific technical structure for an information system (IS). But, why do they continue using it, not wishing to abandon it? This paper uses the functionalist explanation to interpret the contradictory phenomenon through a real case which expects to enhance work efficiency and improve business processes by developing a new IS. During IS development and implementation, the rivalry between IT personnel and users occurs while they closely cooperate. Nevertheless, a shared belief that “IT/IS as the Secret Scroll of Kung Fu”, which implies IT/IS with a magic power, has been unexpectedly developed between them. In other words, both divisions believe that IT/IS would be able to solve all unintended problems to be encountered. Therefore, they still kept cooperating to develop IS, and did not admit the failure of IS

Explore the Functional Connectivity between Brain Regions during a Chemistry Working Memory Task.

Previous studies have rarely examined how temporal dynamic patterns, event-related coherence, and phase-locking are related to each other. This study assessed reaction-time-sorted spectral perturbation and event-related spectral perturbation in order to examine the temporal dynamic patterns in the frontal midline (F), central parietal (CP), and occipital (O) regions during a chemistry working memory task at theta, alpha, and beta frequencies. Furthermore, the functional connectivity between F-CP, CP-O, and F-O were assessed by component event-related coherence (ERCoh) and component phase-locking (PL) at different frequency bands. In addition, this study examined whether the temporal dynamic patterns are consistent with the functional connectivity patterns across different frequencies and time courses. Component ERCoh/PL measured the interactions between different independent components decomposed from the scalp EEG, mixtures of time courses of activities arising from different brain, and artifactual sources. The results indicate that the O and CP regions' temporal dynamic patterns are similar to each other. Furthermore, pronounced component ERCoh/PL patterns were found to exist between the O and CP regions across each stimulus and probe presentation, in both theta and alpha frequencies. The consistent theta component ERCoh/PL between the F and O regions was found at the first stimulus and after probe presentation. These findings demonstrate that temporal dynamic patterns at different regions are in accordance with the functional connectivity patterns. Such coordinated and robust EEG temporal dynamics and component ERCoh/PL patterns suggest that these brain regions' neurons work together both to induce similar event-related spectral perturbation and to synchronize or desynchronize simultaneously in order to swiftly accomplish a particular goal. The possible mechanisms for such distinct component phase-locking and coherence patterns were also further discussed

3D Spheroid Culture Systems for Metastatic Prostate Cancer Dormancy Studies and Anti-Cancer Therapeutics Development.

Prostate cancer is the most common non-skin cancer in United States men. Despite recent advances, mortality still remains high due to the emergence of therapy-resistant cancer cells that metastasize. Recently it has been postulated that only cancer stem cells (CSCs) are able to establish metastases, and therefore are the essential targets to destroy. Unfortunately, current use of CSCs is limited by the small number of CSCs that can be isolated, and the difficulty of culturing the CSCs in vitro. Furthermore, current in vitro-based metastatic prostate cancer models do not faithfully recreate the complex multi-cellular, three-dimensional (3D) tumor microenvironment seen in vivo. It is therefore crucial to develop effective in vitro prostate cancer culture and testing systems that mimic the actual in vivo tumor niche microenvironment. Here we utilized novel microscale technologies to develop an accurate 3D metastatic tumor model for detailed study of metastatic prostate cancer dormancy as well as accurate anti-cancer therapeutics screening and testing in vitro. Guided by the observation that prostate cancer cells parasitize and stay quiescent in the hematopoietic stem cell niche that is rich in osteoblasts and endothelial cells in vivo, a microfluidic device was established to create 3D spheroid culture of prostate cancer cells supported by osteoblasts and endothelial cells. This 3D metastatic prostate cancer model recapitulates the physiologic, dormant growth behavior of prostate cancer cells in the hematopoietic stem cell niche. Furthermore, we developed a hanging drop-based high-throughput platform for general formation, stable long-term culture, and robust drug testing and screening of 3D spheroids. Using this platform, we found significant differences in drug sensitivities against cells cultured under conventional 2D conditions versus physiological 3D models. A variety of techniques and methods were also established to specifically pattern the spatial localization of different co-culture cell types within a spheroid in this platform for accurate engineering of the 3D metastatic prostate cancer niche microenvironment. Collectively, these biological findings and technological innovations have led to advances in the understanding of prostate cancer biology and progress towards development of novel tools and therapeutics to fight against tumorigenic cancer cells.Ph.D.Biomedical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/86364/1/ahsiao_1.pd

Cerebral hemorrhagic infarction following cranioplasty in a shunted patient with tension pneumocephalus resulting from depressed skull and craniodural defect

SummaryA 34-year-old female sustained a severe traumatic brain injury that was treated with decompressive craniectomy and subsequent cranioplasty, then with ventriculoperitoneal shunt about 10 years previously. However, the skull flap was found to be depressed ever since. She was admitted to our hospital for a headache and left hemiparesis with sudden onset. The computed tomography scan displayed tension pneumocephalus in the right frontoparietal region. First, she underwent emergency burr hole drainage and placement of a subdural drain with external ventricular drainage tube. Then her symptoms improved considerably. Unfortunately, 6 months later she was admitted again to our hospital because of headache and left hemiparesis with sudden onset, and the brain computed tomography showed tension pneumocephalus in the right frontoparietal region. She underwent craniectomy to remove the previous depressed skull and simultaneous cranioplasty with Ti-Mesh. On the day of her operation, generalized seizure occurred and her consciousness deteriorated. The magnetic resonance imaging showed hemorrhagic infarction on both sides of the thalamus and the right parieto-occipital region. We think it probable that a sudden increase of cerebral blood flow in the cerebral hemisphere where the cranioplasty had been performed caused reperfusion injury and resulted in hemorrhagic infarction

\u3ci\u3eUncle Tom’s Cabin\u3c/i\u3e in \u3ci\u3eThe National Era\u3c/i\u3e: Commentary on Chapter 1 and 2

In the first chapter of Uncle Tom’s Cabin, Stowe warns her readers that the “indulgence” of slave owners and the “affectionate loyalty” of the slaves themselves towards their masters have misled some observers to believe the “poetic legend” of slavery as a benevolent “patriarchal institution.” She does not deny the genuineness of these emotions, but she warns that “the shadow of a Law” makes a mockery of the human relationships that develop between masters and slaves: “So long as the law considers all these human beings, with beating hearts and living affections, only as so many things belonging to a master—so long as the failure, or misfortune, or imprudence, or death, of the kindest owner, may cause them any day to exchange a life of kind protection and indulgence for one of hopeless misery and toil, so long it is impossible to make anything beautiful or desirable in the best regulated administration of slavery.” We begin the novel, then, in what seems to be the model benevolent Shelby plantation in Kentucky, not the cruel Legree plantation in Louisiana, where the novel ends. Nevertheless, the “shadow of the law,” in the form of Mr. Shelby’s obligation to pay his debts, endangers the residents of the Shelby plantation. Stowe derived her portrait of slavery primarily from reading, not from direct experience and observation in the slave states of the South. She describes Eliza Harris as “not a fancy sketch, but taken from a remembrance, as we saw her years ago in Kentucky”—that is, during Stowe’s one brief trip South of the Mason-Dixon line during her years living in Cincinnati. Some white Southerners attacked Stowe for this lack of direct knowledge of the South and slavery. However, as historian William R. Taylor observed fifty years ago, what troubled them the most about Uncle Tom’s Cabin was not that she attacked their point of view, but that she understood it too well. As Taylor explains, beginning in the 1830s white Southerners invented the legend of “plantation paternalism,” “the image of sunshine and happiness around the plantation home,” to “justif[y] their peculiar institution to themselves and to others.”[1] Stowe only “[took] the Southerner at his word”: she did “not…deny the Southern defense of slavery but…suggested that it was inadequate, even if its claims were allowed.” Stowe set out to show, Taylor explains, that “kindness, generosity and affection provided no assurance against cruelty and brutality” and that “a slave could love his master and mistress and still wish to be free.”[2