Speech intelligibility and prosody production in children with cochlear implants

Objectives—The purpose of the current study was to examine the relation between speech intelligibility and prosody production in children who use cochlear implants. Methods—The Beginner\u27s Intelligibility Test (BIT) and Prosodic Utterance Production (PUP) task were administered to 15 children who use cochlear implants and 10 children with normal hearing. Adult listeners with normal hearing judged the intelligibility of the words in the BIT sentences, identified the PUP sentences as one of four grammatical or emotional moods (i.e., declarative, interrogative, happy, or sad), and rated the PUP sentences according to how well they thought the child conveyed the designated mood. Results—Percent correct scores were higher for intelligibility than for prosody and higher for children with normal hearing than for children with cochlear implants. Declarative sentences were most readily identified and received the highest ratings by adult listeners; interrogative sentences were least readily identified and received the lowest ratings. Correlations between intelligibility and all mood identification and rating scores except declarative were not significant. Discussion—The findings suggest that the development of speech intelligibility progresses ahead of prosody in both children with cochlear implants and children with normal hearing; however, children with normal hearing still perform better than children with cochlear implants on measures of intelligibility and prosody even after accounting for hearing age. Problems with interrogative intonation may be related to more general restrictions on rising intonation, and th

ON DEMAND: CROSS-COUNTRY EVIDENCE FROM COMMERCIAL REAL ESTATE ASSET MARKETS

Using over 25 years of quarterly U.S. and Japanese time series data, this paper examines the determinants of demand for an important class of real assets: commercial real estate. We specify a structural model of market equilibrium that considers direct effects of real investment on built asset price. Our empirical findings are consistent across countries and produce several new results. First, we find that real investment exerts a significant positive direct effect on asset price, which in turn feeds back to impact investment decisions. Second, idiosyncratic risk is found to be strongly positively related to asset price, and to complement supply effects. Third, systematic risk is priced as expected, where the strength of the relation between asset price and systematic risk is found to be higher than in previous studies of capital asset prices. Fourth, lagged values of price determinants (of up to two years) are consistently important in real asset demand estimation. Alternative explanations for our findings are analyzed and discussed. Implications for asset pricing model specification and interpretation are also considered.equity REIT; IPO; interest-rate sensitivity; risk-adjusted return performance

Implementation of Lead Time Improvement in the Cutting Production Process using Clustering Data Mining and Lean Manufacturing

In steel companies, there are some processes in the production such as cutting, machining and heat treatment. The production process begins with cutting process and then machining process and the last one is the heat treatment process. It becomes a background that gives the challenge and needs continuous improvement on all aspects, mainly in the cutting process. The research is conducted at one of steel companies located in Pulogadung Industrial Estate. The purpose of the research is to know the factors which cause process lead time cannot be achieved. The methods used are clustering data mining and lean manufacturing. Clustering method can be used to focus on big data and find out clusters or the same pattern. Those clusters are processed with Weka software and using K-means algorithm. Improvement ideas will be implemented to the formed clusters using lean manufacturing such as Single Minute Exchange of Dies (SMED) which have been mapped through value stream mapping, 5S, and Kanban beforehand. The materials’ dimension on the production process is affecting the cutting process lead time. The thicker material diameters will need a longer time to process. With the methods used, lead time of cutting process increased from 3449 minutes to 2165 minutes (3 days to be 2 days). Meanwhile if the “SMED” activities are implemented, the cutting process lead time increased from 187 minutes to 136 minutes. Keywords: Clustering; SMED; Lean Manufacturing; Process Lead Time; Value Stream Mappin

Subsidence in Coastal Cities Throughout the World Observed by InSAR

We measured subsidence rates in 99 coastal cities around the world between 2015 and 2020 using the PS Interferometric Synthetic Aperture Radar method and Sentinel-1 data. In most cities, part of the land is subsiding faster than sea level is rising. If subsidence continues at present rates, these cities will be challenged by flooding much sooner than projected by sea level rise models. The most rapid subsidence is occurring in South, Southeast, and East Asia. However, rapid subsidence is also happening in North America, Europe, Africa, and Australia. Human activity—primarily groundwater extraction—is likely the main cause of this subsidence. Expanded monitoring and policy interventions are required to reduce subsidence rates and minimize their consequences

Two-dimensional single-valley exciton qubit and optical spin magnetization generation

Creating and manipulating coherent qubit states are actively pursued in two-dimensional (2D) materials research. Significant efforts have been made towards the realization of two-valley exciton qubits in monolayer transition-metal dichalcogenides (TMDs), based on states from their two distinct valleys in k-space. Here, we propose a new scheme to create qubits in 2D materials utilizing a novel kind of degenerate exciton states in a single valley. Combining group theoretic analysis and ab initio GW plus Bethe-Salpeter equation (GW-BSE) calculations, we demonstrate such novel qubit states in substrate-supported monolayer bismuthene -- which has been successfully grown using molecular beam epitaxy. In each of the two distinct valleys in the Brillouin zone, strong spin-orbit coupling along with $C_{3v}$ symmetry leads to a pair of degenerate 1s exciton states with opposite spin configurations. Specific coherent linear combinations of the two degenerate excitons in a single valley can be excited with specific light polarizations, enabling full manipulation of the exciton qubits and their spin configurations. In particular, a net spin magnetization can be generated. Our finding opens new routes to create and manipulate qubit systems in 2D materials.Comment: 27 pages, 5 figure

Cultural Discourse in Taiwan. Ed. Chin-Chuan Cheng, I-Chun Wang, and Steven Tötösy de Zepetnek.

The collected volume Cultural Discourse in Taiwan — edited by Chin-Chuan Cheng, I-Chun Wang, and Steven Tötösy de Zepetnek and published by National Sun Yat-sen Uiniversity Press in 2009 — is intended as an addition to scholarship in the field of Taiwan Studies. The articles in the volume are in many aspects comparative and the topics discussed are in the context of literary and culture scholarship. At the same time, the volume is interdisciplinary as the articles cover historical perspectives, analyses of texts by Taiwan authors, and cultural discourse as related to Taiwan consciousness, language, and linguistic issues. Copyright release to the authors

The Weight of New York City: Possible Contributions to Subsidence From Anthropogenic Sources

New York City faces accelerating inundation risk from sea level rise, subsidence, and increasing storm intensity from natural and anthropogenic causes. Here we calculate a previously unquantified contribution to subsidence from the cumulative mass and downward pressure exerted by the built environment of the city. We enforce that load distribution in a multiphysics finite element model to calculate expected subsidence. Complex surface geology requires multiple rheological soil models to be applied; clay rich soils and artificial fill are calculated to have the highest post-construction subsidence as compared with more elastic soils. Minimum and maximum calculated building subsidence ranges from 0 to 600 mm depending on soil/rock physical parameters and foundation modes. We compare modeled subsidence and surface geology to observed subsidence rates from satellite data (Interferometric Synthetic Aperture Radar and Global Positioning System). The comparison is complicated because the urban load has accumulated across a much longer period than measured subsidence rates, and there are multiple causes of subsidence. Geodetic measurements show a mean subsidence rate of 1–2 mm/year across the city that is consistent with regional post-glacial deformation, though we find some areas of significantly greater subsidence rates. Some of this deformation is consistent with internal consolidation of artificial fill and other soft sediment that may be exacerbated by recent building loads, though there are many possible causes. New York is emblematic of growing coastal cities all over the world that are observed to be subsiding (Wu et al., 2022, https://doi.org/10.1029/2022GL098477), meaning there is a shared global challenge of mitigation against a growing inundation hazard

Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma.

BackgroundIncreasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs would have differential effects on CSC populations depending on their mechanism of action (anti-proliferative vs. anti-angiogenic).MethodsWe exposed human sarcoma cell lines to sorafenib, regorafenib, and pazopanib and assessed cell viability and expression of CSC markers (ALDH, CD24, CD44, and CD133). We evaluated survival and CSC phenotype in mice harboring sarcoma metastases after TKI therapy. We exposed dissociated primary sarcoma tumors to sorafenib, regorafenib, and pazopanib, and we used tissue microarray (TMA) and primary sarcoma samples to evaluate the frequency and intensity of CSC markers after neoadjuvant therapy with sorafenib and pazopanib. Parametric and non-parametric statistical analyses were performed as appropriate.ResultsAfter functionally validating the CSC phenotype of ALDHbright sarcoma cells, we observed that sorafenib and regorafenib were cytotoxic to sarcoma cell lines (P < 0.05), with a corresponding 1.4 - 2.8 fold increase in ALDHbright cells from baseline (P < 0.05). In contrast, we observed negligible effects on viability and CSC sub-populations with pazopanib. At low doses, there was progressive CSC enrichment in vitro after longer term exposure to sorafenib although the anti-proliferative effects were attenuated. In vivo, sorafenib improved median survival by 11 days (P < 0.05), but enriched ALDHbright cells 2.5 - 2.8 fold (P < 0.05). Analysis of primary human sarcoma samples revealed direct cytotoxicity following exposure to sorafenib and regorafenib with a corresponding increase in ALDHbright cells (P < 0.05). Again, negligible effects from pazopanib were observed. TMA analysis of archived specimens from sarcoma patients treated with sorafenib demonstrated significant enrichment for ALDHbright cells in the post-treatment resection specimen (P < 0.05), whereas clinical specimens obtained longitudinally from a patient treated with pazopanib showed no enrichment for ALDHbright cells (P > 0.05).ConclusionsAnti-proliferative TKIs appear to enrich for sarcoma CSCs while anti-angiogenic TKIs do not. The rational selection of targeted therapies for sarcoma patients may benefit from an awareness of the differential impact of TKIs on CSC populations

The prevalence and awareness of sleep apnea in patients suffering chronic pain: an assessment using the STOP-Bang sleep apnea questionnaire.

Purpose: Some patient subsets are at higher risk of sleep apnea, including patients with chronic pain. However, it is unclear whether patients and their caregivers are aware of the possibly increased risk of sleep apnea in this population. Chronic pain is often treated with opioids which may decrease both the central respiratory drive and the patency of the upper airway, potentially contributing to this sleep disorder. Using a self-reporting questionnaire approach in the chronic pain population, this study surveyed patient and caregiver awareness surrounding the risk of sleep apnea. In addition, we looked at the influence of opioid therapy on the prevalence of sleep apnea. Participants and methods: Consecutive patients presenting to a pain clinic were invited to participate anonymously in a survey that included the STOP-Bang sleep apnea questionnaire, which assesses patients\u27 knowledge, testing, diagnosis, or treatment of sleep apnea and whether their caregivers had discussed with them their increased risk of sleep apnea and opioid use. Results: Among 305 participating patients, 58.2% (n=173) screened positive for sleep apnea. Among the 202 patients on opioid therapy, 59.2% (116/202) were STOP-Bang positive (score ≥3). However, only 37.5% (n=72/173) of these patients had discussed their risk of sleep apnea with a caregiver and only 30.7% (n=59) underwent testing. Against expectation, opioids did not increase the prevalence of sleep apnea in our study population. Conclusion: Chronic pain patients had a high risk of sleep apnea, regardless of opioid prescription. Most patients were unaware of their increased risk and denied undergoing the necessary testing. Greater attention to screening, testing, and education for sleep apnea needs to be paid in chronic pain patients, especially given the potentially dangerous ramifications of opioid-induced sleep apnea