Distance sensitivity of thermal light second-order interference beyond spatial coherence

We demonstrate the distance sensitivity of thermal light second-order interference beyond spatial coherence. This kind of interference, emerging from the measurement of the correlation between intensity fluctuations on two detectors, is sensitive to the distances separating a remote mask from the source and the detector, even when such information cannot be retrieved by first-order intensity measurements. We show how the sensitivity to such distances is intimately connected to the degree of correlation of the measured interference pattern in different experimental scenarios and independently of the spectral properties of light. Remarkably, in specific configurations, sensitivity to the distances of remote objects can be preserved even in the presence of turbulence. Unlike in previous schemes, such a distance sensitivity is reflected in the fundamental emergence of new critical parameters which benchmark the degree of second-order correlation, describing the counterintuitive emergence of spatial second-order interference not only in the absence of (first-order) coherence at both detectors but also when first-order interference is observed at one of the two detectors

Architectural Decision Management for Digital Transformation of Products and Services

The digitization of our society changes the way we live, work, learn, communicate, and collaborate. The Internet of Things, Enterprise Social Networks, Adaptive Case Management, Mobility systems, Analytics for Big Data, and Cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and service-oriented enterprise architectures. Our aim is to support flexibility and agile transformations for both business domains and related information technology. The present research paper investigates mechanisms for decision analytics in the context of multi-perspective explorations of enterprise services and their digital enterprise architectures by extending original architecture reference models with state of art elements for agile architectural engineering for the digitization and collaborative architectural decision support. The paper’s context focuses on digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems. We are putting a spotlight on the example domain – Internet of Things

Late-onset n-acetylglutamate synthase deficiency: Report of a paradigmatic adult case presenting with headaches and review of the literature

N-acetylglutamate synthase deficiency (NAGSD) is an extremely rare urea cycle disorder (UCD) with few adult cases so far described. Diagnosis of late-onset presentations is difficult and delayed treatment may increase the risk of severe hyperammonemia. We describe a 52-year-old woman with recurrent headaches who experienced an acute onset of NAGSD. As very few papers focus on headaches in UCDs, we also report a literature review of types and pathophysiologic mechanisms of UCD-related headaches. In our case, headaches had been present since puberty (3-4 days a week) and were often accompanied by nausea, vomiting, or behavioural changes. Despite three previous episodes of altered consciousness, ammonia was measured for the first time at 52 years and levels were increased. Identification of the new homozygous c.344C>T (p.Ala115Val) NAGS variant allowed the definite diagnosis of NAGSD. Bioinformatic analysis suggested that an order/disorder alteration of the mutated form could affect the arginine-binding site, resulting in poor enzyme activation and late-onset presentation. After optimized treatment for NAGSD, ammonia and amino acid levels were constantly normal and prevented other headache bouts. The manuscript underlies that headache may be the presenting symptom of UCDs and provides clues for the rapid diagnosis and treatment of late-onset NAGSD