A multidisciplinary study of chemico-physical properties of different classes of 2-aryl-5(or 6)-nitrobenzimidazoles: NMR, electrochemical behavior, ESR, and DFT calculations

Continuing in our researches on the syntheses, reactivity, pharmacological/biological activities of heterocyclic compounds containing one or more nitrogen atoms we have examined some chemico-physical properties (1H and 13C NMR, electrochemical behavior, and ESR) of three series of 2-aryl-5(or 6)-nitrobenzimidazoles (1–3) variously substituted in the 2-aryl ring. The electrochemical behavior of the nitro group on the benzimidazole ring has been studied by cyclic voltammetry. This has allowed to point out both the reversibility, the formal potential, and the number of electrons involved in the electrochemical processes, and to evaluate the effect of the substituents present on the aryl ring. The data collected have been able to furnish a complete picture of electronic distribution and have been supported by DFT calculations

Impact du statut socio-économique sur le comportement et les performances scolaires des enfants scolarisés au Maroc

Parmi les facteurs principaux qui paraissent déterminer le cursus scolaire de l’enfant on cite principalement l’environnement socio-économique. L’objectif de cette étude est d’étudier l’effet des facteurs socio-économiques sur les performances scolaires des enfants âgées de 6 à 14 ans d’une école public primaire dans la province d’AZILAL (Maroc). Les informations concernant ces enfants sont collectées en utilisant un questionnaire enregistrant l’âge, les mesures anthropométriques, les facteurs socioéconomiques aussi que l’appréciation des déterminants des performances scolaires et comportementales de l’individu. Pour chaque déterminant, l'échantillon enquête a été groupé en deux afin d'adopter une étude comparative. Le traitement des résultats a été fait en utilisant le logiciel SPSS version 20.Les résultats montrent qu’il existe une dépendance significative entre l’assiduité et le comportement dans les activités scolaires d’une part et le niveau d’instruction du père d’une autre part (p<0,05). Les résultats montrent aussi qu’il y a une dépendance significative entre l’assiduité et le revenu du ménage (CHI2= 14,80). Les facteurs socio-économiques étudiés influencent négativement sur l’aptitude de l’élève à progresser dans son parcours scolaire

Chemical Profile of Lipophilic Fractions of Different Parts of Zizyphus lotus L. by GC-MS and Evaluation of Their Antiproliferative and Antibacterial Activities

Zizyphus lotus L. is a perennial shrub particularly used in Algerian folk medicine, but little is known concerning the lipophilic compounds in the most frequently used parts, namely, root bark, pulp, leaves and seeds, which are associated with health benefits. In this vein, the lipophilic fractions of these morphological parts of Z. lotus from Morocco were studied by gas chromatography–mass spectrometry (GC–MS), and their antiproliferative and antimicrobial activities were evaluated. GC– MS analysis allowed the identification and quantification of 99 lipophilic compounds, including fatty acids, long-chain aliphatic alcohols, pentacyclic triterpenic compounds, sterols, monoglycerides, aromatic compounds and other minor components. Lipophilic extracts of pulp, leaves and seeds were revealed to be mainly composed of fatty acids, representing 54.3–88.6% of the total compounds detected. The leaves and seeds were particularly rich in unsaturated fatty acids, namely, (9Z,12Z)-octadeca-9,12-dienoic acid (2431 mg kg−1 of dry weight) and (9Z)-octadec-9-enoic acid (6255 mg kg−1 of dry weight). In contrast, root bark contained a high content of pentacyclic triterpenic compounds, particularly betulinic acid, accounting for 9838 mg kg−1 of dry weight. Root bark extract showed promising antiproliferative activity against a triple-negative breast cancer cell line, MDA-MB-231, with a half-maximal inhibitory concentration (IC50 ) = 4.23 ± 0.18 µg mL−1 of extract. Leaf extract displayed interesting antimicrobial activity against Escherichia coli, methicillin-sensitive Staphylococcus aureus and Staphylococcus epidermis, presenting minimum inhibitory concentration (MIC) values from 1024 to 2048 µg mL−1 of extract. Our results demonstrate that Zizyphus lotus L. is a source of promising bioactive components, which can be exploited as natural ingredients in pharmaceutical formulationspublishe

Synthesis and In Silico Analysis of New Polyheterocyclic Molecules Derived from [1,4]-Benzoxazin-3-one and Their Inhibitory Effect against Pancreatic &alpha;-Amylase and Intestinal &alpha;-Glucosidase

This study focuses on synthesizing a new series of isoxazolinyl-1,2,3-triazolyl-[1,4]-benzoxazin-3-one derivatives 5a&ndash;5o. The synthesis method involves a double 1,3-dipolar cycloaddition reaction following a &ldquo;click chemistry&rdquo; approach, starting from the respective [1,4]-benzoxazin-3-ones. Additionally, the study aims to evaluate the antidiabetic potential of these newly synthesized compounds through in silico methods. This synthesis approach allows for the combination of three heterocyclic components: [1,4]-benzoxazin-3-one, 1,2,3-triazole, and isoxazoline, known for their diverse biological activities. The synthesis procedure involved a two-step process. Firstly, a 1,3-dipolar cycloaddition reaction was performed involving the propargylic moiety linked to the [1,4]-benzoxazin-3-one and the allylic azide. Secondly, a second cycloaddition reaction was conducted using the product from the first step, containing the allylic part and an oxime. The synthesized compounds were thoroughly characterized using spectroscopic methods, including 1H NMR, 13C NMR, DEPT-135, and IR. This molecular docking method revealed a promising antidiabetic potential of the synthesized compounds, particularly against two key diabetes-related enzymes: pancreatic &alpha;-amylase, with the two synthetic molecules 5a and 5o showing the highest affinity values of 9.2 and 9.1 kcal/mol, respectively, and intestinal &alpha;-glucosidase, with the two synthetic molecules 5n and 5e showing the highest affinity values of &minus;9.9 and &minus;9.6 kcal/mol, respectively. Indeed, the synthesized compounds have shown significant potential as antidiabetic agents, as indicated by molecular docking studies against the enzymes &alpha;-amylase and &alpha;-glucosidase. Additionally, ADME analyses have revealed that all the synthetic compounds examined in our study demonstrate high intestinal absorption, meet Lipinski&rsquo;s criteria, and fall within the required range for oral bioavailability, indicating their potential suitability for oral drug development

Prevalence and Predictors of Gestational Hypertension: a Cross-Sectional Study among Moroccan Pregnant Women

The objective of this study was to assess the prevalence of gestational hypertension, and to determine its predictors among pregnant women attending primary health care facilities in Beni Mellal city in Morocco. The prevalence of gestational hypertension was 18.7%. The low monthly household income (Adjusted Odds Ratio (AOR) = 7.874; IC 95% = [1.788–34.67]), gestational age less than 37 weeks (AOR = 6.860; IC 95% = [1.285–36.626]), limited knowledge on gestational hypertension (AOR = 12.719; IC 95% = [3.386–47.785]), and primigravidity (AOR = 9.047; IC 95% = [1.595–51.324]), were significantly associated with gestational hypertension.</jats:p

Eating habits, lifestyle factors and body weight status among Moroccan school adolescents (12–19 years): The case of Beni Mellal city

BACKGROUND: Overweight and obesity among children and adolescents are serious public health issues worldwide. A better understanding of the relationships between obesity and lifestyle factors is necessary for effective prevention and management of obesity in youth. AIMS: This study aimed to assess the prevalence of overweight/obesity and associated factors among schoolchildren aged 12–19 years at Beni Mellal city, Morocco. METHODS: A school based cross sectional study was carried out. A total of 516 children were included in the study. The nutritional status was classified according to the reference curves of WHO (2007). Multivariable logistic regression analysis was used to identify factors associated with overweight/obesity. The association between dependent and independent variables were assessed using odds ratio with 95% confidence interval and p value &lt; 0.05 was considered statistically significant. RESULTS: The prevalence of overweight was 12.40% and that of obesity was 5.20%. Overweight and obesity were statistically associated with gender (Odds Ratio (OR) = 10.15[95% CI 1.37–3.81], p = 0.001); skipping breakfast (OR = 9.19 [95% CI 1.42–5.17], p = 0.002) and eating cake, pastry and biscuit 1 to 3 times per week (OR = 4.14 [95% CI 1.02–3.25], p = 0.04) and 4 or more times a week (OR = 7.83 [95% CI 1.31–4.66], p = 0.005). CONCLUSIONS: This study revealed that prevalence of overweight/obesity among school-aged children in Beni Mellal city was high. Thus, promoting healthy dietary practices, particularly improving fruit and vegetable intake is essential to reduce the burden of overweight and obesity. Furthermore, it is important to strengthen nutrition education about avoiding junk food consumption and encouraging regular physical activity.</jats:p