2,277 research outputs found
Comparison of two rocuronium bromide doses in adult and elderly patients who underwent laparoscopic surgery
Background The aim of our study was to evaluate the effects of two different doses of rocuronium bromide (0.5 mg/kg and 0.9 mg/kg) on the length of neuromuscular block, on the haemodynamic stability and on the side effects in patients of different ages. Methods We recruited 80 patients who underwent laparoscopic surgery (cholecystectomy, appendicectomy, varicocelectomy) belonging to ASA I–II classes and divided them into four groups:• 20 adults (A0.5) who received rocuronium bromide 0.5 mg/kg• 20 elderly patients (E0.5) who received rocuronium bromide 0.5 mg/kg• 20 adults (A0.9) who received rocuronium bromide 0.9 mg/kg• 20 elderly patients (E0.9) who received rocuronium bromide 0.9 mg/kgIntubation conditions, continuous monitoring of HR, NIBP, SpO2, EtCO2 were recorded. Onset time, REC 25%, TOF-ratio 0.70 were analysed by TOF-WATCH.Nerve-evoked muscle tension and neuromuscular paralysis extension were expressed by strength of contraction of adductor pollicis, in response to a direct stimulation of the ulnar nerve (TOF). Results The results showed that in elderly patients the effect of rocuronium bromide, at two different doses, was similar. Significant differences regarding the onset time was found among the groups showing that with the same dose of rocuronium bromide, the onset time was prolonged in elderly patients compared to adult patients. Moreover, increasing the dose, the onset time was reduced in both groups (p < 0.05). Forty per cent of adult group A0.5 showed excellent intubation conditions versus 60% of A0.9 (p < 0.05); elderly patients did not show any significant difference in the intubation procedure after different doses of rocuronium bromide.ConclusionsThe results from the four groups showed that in elderly patients 0.5 mg/kg of rocuronium bromide resulted in a good recovery, while 0.9 mg/kg increased the recovery time. Moreover, in adults the high dose was more effective because it reduced the number of injections and post-operative recovery time
Synthesis and characterization of hybrid organic-inorganic materials based on sulphonated polyamideimide and silica
The preparation of hybrid organic–inorganic
membrane materials based on a sulphonated polyamideimide
resin and silica filler has been studied. The method
allows the sol–gel process to proceed in the presence of a
high molecular weight polyamideimide, resulting in well
dispersed silica nanoparticles (<50 nm) within the polymer
matrix with chemical bonding between the organic and
inorganic phases. Tetraethoxysilane (TEOS) was used as
the silica precursor and the organosilicate networks were
bonded to the polymer matrix via a coupling agent
aminopropyltriethoxysilane (APTrEOS). The structure and
properties of these hybrid materials were characterized via a
range of techniques including FTIR, TGA, DSC, SEM and
contact angle analysis. It was found that the compatibility
between organic and inorganic phases has been greatly
enhanced by the incorporation of APTrEOS. The thermal
stability and hydrophilic properties of hybrid materials have
also been significantly improved
Quasifree pion photoproduction on the deuteron in the region
Photo production of pions on the deuteron is studied in the spectator nucleon
model. The Born terms of the elementary production amplitude are determined in
pseudovector N coupling and supplied with a form factor. The
resonance is considered both in the and the channel. The parameters of
the resonance and the cutoff of the form factors are fixed on the
leading photoproduction multipoles. Results for total and differential cross
sections are compared with experimental data. Particular attention is paid to
the role of Pauli correlations of the final state nucleons in the quasifree
case. The results are compared with those for pion photoproduction on the
nucleon.Comment: 17 pages LateX2e including 5 postscript figure
HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway
High-mobility group AT-hook 1 (HMGA1) protein is an important nuclear factor that activates gene transcription by binding to AT-rich sequences in the promoter region of DNA. We previously demonstrated that HMGA1 is a key regulator of the insulin receptor (INSR) gene and individuals with defects in HMGA1 have decreased INSR expression and increased susceptibility to type 2 diabetes mellitus. In addition, there is evidence that intracellular regulatory molecules that are employed by the INSR signaling system are involved in post-translational modifications of HMGA1, including protein phosphorylation. It is known that phosphorylation of HMGA1 reduces DNA-binding affinity and transcriptional activation. In the present study, we investigated whether activation of the INSR by insulin affected HMGA1 protein phosphorylation and its regulation of gene transcription. Collectively, our findings indicate that HMGA1 is a novel downstream target of the INSR signaling pathway, thus representing a new critical nuclear mediator of insulin action and function
Study of the a_0(980) meson via the radiative decay phi->eta pi^0 gamma with the KLOE detector
We have studied the phi->a_0(980) gamma process with the KLOE detector at the
Frascati phi-factory DAPhNE by detecting the phi->eta pi^0 gamma decays in the
final states with eta->gamma gamma and eta->pi^+ pi^- pi^0. We have measured
the branching ratios for both final states: Br(phi->eta pi^0 gamma)=(7.01 +/-
0.10 +/- 0.20)x10^-5 and (7.12 +/- 0.13 +/- 0.22)x10^-5 respectively. We have
also extracted the a_0(980) mass and its couplings to eta pi^0, K^+ K^-, and to
the phi meson from the fit of the eta pi^0 invariant mass distributions using
different phenomenological models.Comment: 17 pages, 6 figures, submitted to Physics Letters B. Corrected typos
in eq.
Charged kaon lifetime at KLOE
Preliminary result on the charged kaon lifetime, obtained by the KLOE
experiment operating at DANE, the Frascati -factory, is presentedComment: 3 pages, 3 figures, to appear in the proceedings of 42nd Rencontres
de Moriond on Electroweak Interactions and Unified Theories, La Thuile, Aosta
Valley, Italy, 10-17 Mar 200
Measurement of the K_L \to \pi\mu\nu form factor parameters with the KLOE detector
Using 328 pb^{-1}of data collected at DAFNE corresponding to 1.8
million decays, we have measured the form factor
parameters. The structure of the vector-current provides information
about the dynamics of the strong interaction; its knowledge is necessary for
evaluation of the phase-space integral required for measuring the CKM matrix
element and for testing lepton universality in kaon decays. Using a
new parametrization for the vector and scalar form factors, we find
=\pt(25.7\pm 0.6),-3, and =\pt(14.0\pm 2.1),-3,. Our
result for , together with recent lattice calculations of ,
and , satisfies the Callan-Trieman relatio
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